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作者:Hannah L. Mackay , Patricia A.J. Muller
来源:[J].Biochemical Society Transactions(IF 2.587), 2019, Vol.47 (2), pp.725-732波特兰出版社
摘要:Cell-in-cell (CIC) is a term used to describe the presence of one, usually living, cell inside another cell that is typically considered non-phagocytic. Examples of this include tumour cells inside tumour cells (homotypic), mesenchymal stem cells inside tumour cells (heterotypic)...
作者:Heejeong Lee , Jae Sam Hwang , Dong Gun Lee
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (8), pp.1267-1284波特兰出版社
摘要:Communications between various organelle–organelles play an essential role in cell survival. The cross-talk between mitochondria and vacuoles comes up with the vital roles of the intercompartmental process. In this study, we found a couple of cell death features, membrane da...
作者:Ayan Adhikari , Saroj Biswas , Aditi Mukherjee ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (8), pp.1303-1321波特兰出版社
摘要:Per-Arnt-Sim (PAS) domains are structurally conserved and present in numerous proteins throughout all branches of the phylogenetic tree. Although PAS domain-containing proteins are major players for the adaptation to environmental stimuli in both prokaryotic and eukaryotic o...
作者:Monica Napolitano
来源:[J].Biochemical Society Transactions(IF 2.587), 2019, Vol.47 (2), pp.743-754波特兰出版社
摘要:The G protein-coupled receptors (GPCRs) constitute a large superfamily of seven transmembrane-spanning receptors that are activated by several classes of ligands, including bioactive lipids. GPCRs are attractive therapeutic targets for the treatment of human diseases, as the...
作者:Yuri N. Utkin , Ulrich Kuch , Igor E. Kasheverov ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (8), pp.1285-1302波特兰出版社
摘要:αδ-Bungarotoxins, a novel group of long-chain α-neurotoxins, manifest different affinity to two agonist/competitive antagonist binding sites of muscle-type nicotinic acetylcholine receptors (nAChRs), being more active at the interface of α–δ subunits. Three isoforms (αδ...
作者:Sally L. Perrin , Michael S. Samuel , Barbara Koszyca ...
来源:[J].Biochemical Society Transactions(IF 2.587), 2019, Vol.47 (2), pp.625-638波特兰出版社
摘要:Glioblastoma is the deadliest form of brain cancer. Aside from inadequate treatment options, one of the main reasons glioblastoma is so lethal is the rapid growth of tumour cells coupled with continuous cell invasion into surrounding healthy brain tissue. Significant intra- and i...
作者:Shijie Wang , Andrew B. West
来源:[J].Biochemical Society Transactions(IF 2.587), 2019, Vol.47 (2), pp.663-670波特兰出版社
摘要:Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a frequent genetic cause of late-onset Parkinson's disease (PD) and a target for therapeutic approaches. LRRK2 protein can influence vesicle trafficking events in the cytosol, with action both in endosomal and lysosom...
作者:Bethany R. Jose , Paul P. Gardner , Lars Barquist
来源:[J].Biochemical Society Transactions(IF 2.587), 2019, Vol.47 (2), pp.527-539波特兰出版社
摘要:Understanding how new genes originate and integrate into cellular networks is key to understanding evolution. Bacteria present unique opportunities for both the natural history and experimental study of gene origins, due to their large effective population sizes, rapid generation...
作者:Zhanjun Hou , Carrie O'Connor , Josephine Frühauf ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (8), pp.1247-1266波特兰出版社
摘要:Tumors can be therapeutically targeted with novel antifolates (e.g. AGF94 ) that are selectively transported by the human proton-coupled folate transporter (hPCFT). Studies were performed to determine the transcription regulation of hPCFT in tumors and identify possible mech...
作者:Katrin Ottersbach
来源:[J].Biochemical Society Transactions(IF 2.587), 2019, Vol.47 (2), pp.591-601波特兰出版社
摘要:The first definitive blood cells during embryogenesis are derived from endothelial cells in a highly conserved process known as endothelial-to-haematopoietic transition (EHT). This conversion involves activation of a haematopoietic transcriptional programme in a subset of en...

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