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作者:Bin Li , Shin Kurihara , Sok Ho Kim ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (18), pp.2579-2594波特兰出版社
摘要:The only known function of S -adenosylmethionine decarboxylase (AdoMetDC) is to supply, with its partner aminopropyltransferase enzymes such as spermidine synthase (SpdSyn), the aminopropyl donor for polyamine biosynthesis. Polyamine spermidine is probably essential for the ...
作者:Juan Alejandro Perdomo , Gustaf E. Degen , Dawn Worrall ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (18), pp.2595-2606波特兰出版社
摘要:Rubisco activase (Rca) is a catalytic chaperone that remodels the active site, promotes the release of inhibitors and restores catalytic competence to Rubisco. Rca activity and its consequent effect on Rubisco activation and photosynthesis are modulated by changes to the chl...
作者:Ngee Kiat Chua , Nicola A. Scott , Andrew J. Brown
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (18), pp.2545-2560波特兰出版社
摘要:Squalene monooxygenase (SM) is an essential rate-limiting enzyme in cholesterol synthesis. SM degradation is accelerated by excess cholesterol, and this requires the first 100 amino acids of SM (SM N100). This process is part of a protein quality control pathway called endop...
作者:Herbert Kaltner , José Abad-Rodríguez , Anthony P. Corfield ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (18), pp.2623-2655波特兰出版社
摘要:Ubiquitous occurrence in Nature, abundant presence at strategically important places such as the cell surface and dynamic shifts in their profile by diverse molecular switches qualifies the glycans to serve as versatile biochemical signals. However, their exceptional structu...
作者:Thomas Trunk , Michael A. Casasanta , Christopher C. Yoo ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (18), pp.2657-2676波特兰出版社
摘要:Autotransporters, or type 5 secretion systems, are widespread surface proteins of Gram-negative bacteria often associated with virulence functions. Autotransporters consist of an outer membrane β-barrel domain and an exported passenger. In the poorly studied type 5d subclass...
作者:Catarina Felisberto-Rodrigues , Jemima C. Thomas , Craig McAndrew ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (18), pp.2521-2543波特兰出版社
摘要:DHX8 is a crucial DEAH-box RNA helicase involved in splicing and required for the release of mature mRNA from the spliceosome. Here, we report the biochemical characterisation of full-length human DHX8 and the catalytically active helicase core DHX8Δ547, alongside crystal st...
作者:Cody Lemke , Kevin C. Potter , Samuel Schulte ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (18), pp.2607-2621波特兰出版社
摘要:All land plants contain at least one class II diterpene cyclase (DTC), which utilize an acid-base catalytic mechanism, for the requisite production of ent -copalyl diphosphate ( ent -CPP) in gibberellin A (GA) phytohormone biosynthesis. These ent -CPP synthases (CPSs) are hy...
作者:Quynh-Anh Thi Nguyen , Juyong Choi , Jin Kuk Yang ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (18), pp.2561-2577波特兰出版社
摘要:Misfolded proteins in the endoplasmic reticulum (ER) are removed through multistep processes termed ER-associated degradation (ERAD). Valosin-containing protein (VCP) plays a crucial role in ERAD as the interaction of ubiquitin fusion degradation protein 1 (Ufd1) with VCP vi...

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