波特兰出版社
期刊
会议
图书
作者:Lina Wang , Ce Zhang , Shijin Sun ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (16), pp.2355-2369波特兰出版社
摘要:Hepsin is a transmembrane serine protease implicated in many biological processes, including hepatocyte growth, urinary protein secretion, auditory nerve development, and cancer metastasis. Zymogen activation is critical for hepsin function. To date, how hepsin is activated and r...
作者:Neha Amatya , David Yin-wei Lin , Amy H. Andreotti
来源:[J].Biochemical Society Transactions(IF 2.587), 2019, Vol.47 (4), pp.1101-1116波特兰出版社
摘要:The SRC, Abelson murine leukemia viral oncogene homolog 1, TEC and C-terminal SRC Kinase families of non-receptor tyrosine kinases (collectively the Src module kinases) mediate an array of cellular signaling processes and are therapeutic targets in many disease states. Crystal st...
作者:Saynaz A. Choudhary , Nikita Bora , Dipanjan Banerjee ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (16), pp.2371-2391波特兰出版社
摘要:Saturated free fatty acid-induced adipocyte inflammation plays a pivotal role in implementing insulin resistance and type 2 diabetes. Recent reports suggest A2A adenosine receptor (A2AAR) could be an attractive choice to counteract adipocyte inflammatio...
作者:Joseph P. Dewulf , Isabelle Gerin , Mark H. Rider ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (16), pp.2427-2447波特兰出版社
摘要:Most fatty acids (FAs) are straight chains and are synthesized by fatty acid synthase (FASN) using acetyl-CoA and malonyl-CoA units. Yet, FASN is known to be promiscuous as it may use methylmalonyl-CoA instead of malonyl-CoA and thereby introduce methyl-branches. We have recently...
作者:Paul G. Shiels , Sarah Buchanan , Colin Selman ...
来源:[J].Biochemical Society Transactions(IF 2.587), 2019, Vol.47 (4), pp.1165-1172波特兰出版社
摘要:Ageing is a process of decline in physiological function and capability over time. It is an anticipated major burden on societal health-care costs due to an increasingly aged global population. Accelerated biological ageing is a feature of age-related morbidities, which also...
作者:Silvia Costa , Caroline Dean
来源:[J].Biochemical Society Transactions(IF 2.587), 2019, Vol.47 (4), pp.1187-1196波特兰出版社
摘要:Polycomb-mediated epigenetic silencing is central to correct growth and development in higher eukaryotes. The evolutionarily conserved Polycomb repressive complex 2 (PRC2) transcriptionally silences target genes through a mechanism requiring the histone modification H3K27me3. How...
作者:David G. Priest , Ashleigh Solano , Jieqiong Lou ...
来源:[J].Biochemical Society Transactions(IF 2.587), 2019, Vol.47 (4), pp.1117-1129波特兰出版社
摘要:Nuclear architecture is fundamental to the manner by which molecules traverse the nucleus. The nucleoplasm is a crowded environment where dynamic rearrangements in local chromatin compaction locally redefine the space accessible toward nuclear protein diffusion. Here, we review a...
作者:Mark G. Waugh
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (16), pp.2321-2346波特兰出版社
摘要:Phosphatidylinositol 4-phosphate (PI4P) is a membrane glycerophospholipid and a major regulator of the characteristic appearance of the Golgi complex as well as its vesicular trafficking, signalling and metabolic functions. Phosphatidylinositol 4-kinases, and in particular t...
作者:Hannah Schneider , Evelin Berger , Brendan Dolan ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (16), pp.2281-2295波特兰出版社
摘要:Transmembrane mucin MUC17 is an integral part of the glycocalyx as it covers the brush border membrane of small intestinal enterocytes and presents an extended O -glycosylated mucin domain to the intestinal lumen. Here, we identified two unknown phosphorylated serine residue...
作者:Elizabeth R. Morris , Ian A. Taylor
来源:[J].Biochemical Society Transactions(IF 2.587), 2019, Vol.47 (4), pp.1013-1027波特兰出版社
摘要:Vertebrate protein SAMHD1 (sterile-α-motif and HD domain containing protein 1) regulates the cellular dNTP (2′-deoxynucleoside-5′-triphosphate) pool by catalysing the hydrolysis of dNTP into 2′-deoxynucleoside and triphosphate products. As an important regulator of cell...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×