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作者:Wided Souissi , Arnold Kaloki , Stuart Etherington ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (24), pp.3805-3816波特兰出版社
摘要:Bacillus thuringiensis (Bt) is a gram positive spore forming bacterium which produces intracellular protein crystals toxic to a wide variety of insect larvae and is the most commonly used biological pesticide worldwide. More recently, Bt crystal proteins known as parasporins have...
作者:Aliyath Susmitha , Kesavan Madhavan Nampoothiri , Harsha Bajaj
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (24), pp.3835-3847波特兰出版社
摘要:Most Gram-positive bacteria contain a membrane-bound transpeptidase known as sortase which covalently incorporates the surface proteins on to the cell wall. The sortase-displayed protein structures are involved in cell attachment, nutrient uptake and aerial hyphae formation....
作者:Michael G. Friedrich , Zhen Wang , Kevin L. Schey ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (24), pp.3817-3834波特兰出版社
摘要:Long-lived proteins (LLPs) are present in numerous tissues within the human body. With age, they deteriorate, often leading to the formation of irreversible modifications such as peptide bond cleavage and covalent cross-linking. Currently understanding of the mechanism of fo...
作者:Mirco Dindo , Silvia Grottelli , Giannamaria Annunziato ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (24), pp.3751-3768波特兰出版社
摘要:Peroxisomal alanine:glyoxylate aminotransferase (AGT) is responsible for glyoxylate detoxification in human liver and utilizes pyridoxal 5′-phosphate (PLP) as coenzyme. The deficit of AGT leads to Primary Hyperoxaluria Type I (PH1), a rare disease characterized by calcium ox...
作者:Alessandro G. Salerno , Thiago Rentz , Gabriel G. Dorighello ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (24), pp.3769-3789波特兰出版社
摘要:The atherosclerosis prone LDL receptor knockout mice (Ldlr−/−, C57BL/6J background) carry a deletion of the NADP(H)-transhydrogenase gene (Nnt) encoding the mitochondrial enzyme that catalyzes NADPH synthesis. Here we hypothesize that both increased NADPH consumption (due to...
作者:Steven Cupello , Yunfeng Lin , Shan Yan
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (24), pp.3791-3804波特兰出版社
摘要:Oxidative DNA damage represents one of the most abundant DNA lesions. It remains unclear how DNA repair and DNA damage response (DDR) pathways are co-ordinated and regulated following oxidative stress. While XRCC1 has been implicated in DNA repair, it remains unknown how exa...
作者:Avani Vyas , Umamaheswar Duvvuri , Kirill Kiselyov
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (24), pp.3705-3719波特兰出版社
摘要:Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinu...
作者:Aphrodite T. Choumessi , Manuel Johanns , Claire Beaufay ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (24), pp.3687-3704波特兰出版社
摘要:Root extracts of a Cameroon medicinal plant, Dorstenia psilurus , were purified by screening for AMP-activated protein kinase (AMPK) activation in incubated mouse embryo fibroblasts (MEFs). Two isoprenylated flavones that activated AMPK were isolated. Compound 1 was identifi...
作者:Almut Dufner , Klaus-Peter Knobeloch
来源:[J].Biochemical Society Transactions(IF 2.587), 2019, Vol.47 (6), pp.1867-1879波特兰出版社
摘要:Protein modification by ubiquitin is one of the most versatile posttranslational regulations and counteracted by almost 100 deubiquitinating enzymes (DUBs). USP8 was originally identified as a growth regulated ubiquitin-specific protease and is like many other DUBs character...
作者:Thomas Hermanns , Kay Hofmann
来源:[J].Biochemical Society Transactions(IF 2.587), 2019, Vol.47 (6), pp.1857-1866波特兰出版社
摘要:Protein ubiquitination is a posttranslational modification that regulates many aspects of cellular life, including proteostasis, vesicular trafficking, DNA repair and NF-κB activation. By directly targeting intracellular bacteria or bacteria-containing vacuoles to the lysoso...

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