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作者:Walter R. P. Novak , Korbin H. J. West , Lucy M. D. Kirkman ...
来源:[J].Acta Crystallogr F Struct Biol Commun, 2018, Vol.74 (Pt 10), pp.664-668IUCr
摘要:The development of antimalarial drugs remains a public health priority, and the orotidine 5″-monophosphate decarboxylase from Plasmodium falciparum (PfOMPDC) has great potential as a drug target. The crystallization of PfOMPDC with substrate bound represents an important adv...
作者:Ning Ning Chen , Jian Ling Ni , Jun Wang
来源:[J].Acta Crystallogr C Struct Chem, 2018, Vol.74 (Pt 10), pp.1123-1127IUCr
摘要:A novel two-dimensional CoII coordination framework, namely poly[(Μ 2 -biphenyl-4,4″-diyldicarboxylato-κ2O4:O4″){Μ 2 -bis[4-(2-methyl-1H-imidazol-1-yl)phenyl] ether-κ2N3:N3″}cobalt(II)], [...
作者:Fuming Luo , Guodong Tang , Jinfang Zhang
来源:[J].Acta Crystallogr C Struct Chem, 2018, Vol.74 (Pt 10), pp.1133-1137IUCr
摘要:The title compound, poly[(Μ 2 -formato-κ3O,O″:O)[Μ 2 -4-(pyridin-4-yl)benzoato-κ3N:O,O″]zinc(II)], [Zn(C 12 H 8 NO 2 )(HCOO)] n , has been synthesized in situ and characterized by thermogravimetric analysis (TGA) and single-crystal and powder X-ray...
作者:Changlin Xie , Chao He , Yiyang Jiang ...
来源:[J].Acta Crystallogr D Struct Biol, 2018, Vol.74 (Pt 10), pp.1027-1038IUCr
摘要:The FHA domain-containing protein Mek1 is a meiosis-specific kinase that is involved in the regulation of interhomolog recombination in meiosis in Saccharomyces cerevisiae. The recruitment and activation of Mek1 require the phosphorylation of the chromosome axis protein Hop1 at T...
作者:Shu Moriyama , Kazuya Nishio , Tsunehiro Mizushima
来源:[J].Acta Crystallogr F Struct Biol Commun, 2018, Vol.74 (Pt 10), pp.617-624IUCr
摘要:Malate dehydrogenase (MDH), a carbohydrate and energy metabolism enzyme in eukaryotes, catalyzes the interconversion of malate to oxaloacetate (OAA) in conjunction with that of nicotinamide adenine dinucleotide (NAD+) to NADH. Three isozymes of MDH have been repor...
作者:Lisha Ha , Jennifer Colquhoun , Nicholas Noinaj ...
来源:[J].Acta Crystallogr F Struct Biol Commun, 2018, Vol.74 (Pt 10), pp.632-637IUCr
摘要:Staphylococcus aureus ribonuclease-P-protein subunit (RnpA) is a promising antimicrobial target that is a key protein component for two essential cellular processes, RNA degradation and transfer-RNA (tRNA) maturation. The first crystal structure of RnpA from the pathogenic b...
作者:Jun Ling Song , Wen Xiu Lu , Tian Shuo Guo ...
来源:[J].Acta Crystallogr C Struct Chem, 2018, Vol.74 (Pt 10), pp.1146-1152IUCr
摘要:Germanophosphates, as a young class of metal phosphates, have been less reported but might possess more diverse structural types and potential applications. Here, two one-dimensional (1D) alkali-metal germanophosphates (GePOs), namely, hydrogen hexakis(Μ-hydrogen phosphato)d...
作者:Jahaun Azadmanesh , William E. Lutz , Kevin L. Weiss ...
来源:[J].Acta Crystallogr F Struct Biol Commun, 2018, Vol.74 (Pt 10), pp.677-687IUCr
摘要:Human manganese superoxide dismutase (MnSOD) is one of the most significant enzymes in preventing mitochondrial dysfunction and related diseases by combating reactive oxygen species (ROS) in the mitochondrial matrix. Mitochondria are the source of up to 90% of cellular ROS genera...
作者:Nicole Maurici , Nicole Savidge , Byung Uk Lee ...
来源:[J].Acta Crystallogr F Struct Biol Commun, 2018, Vol.74 (Pt 10), pp.650-655IUCr
摘要:The X-ray crystal structures of two superfolder green fluorescent protein (sfGFP) constructs containing a genetically incorporated spectroscopic reporter unnatural amino acid, 4-nitro-L-phenylalanine (pNO 2 F), at two unique sites in the protein have been determined. Amber c...
作者:Kwang Seung Park , Myoung Ki Hong , Jin Wan Jeon ...
来源:[J].Acta Crystallogr F Struct Biol Commun, 2018, Vol.74 (Pt 10), pp.644-649IUCr
摘要:Metallo-Β-lactamases (MBLs) are present in major Gram-negative pathogens and environmental species, and pose great health risks because of their ability to hydrolyze the Β-lactam rings of antibiotics such as carbapenems. PNGM-1 was the first reported case of a subclass B3 MB...

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