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作者:Tzu Ping Ko , Xiansha Xiao , Rey Ting Guo ...
来源:[J].Acta Crystallogr F Struct Biol Commun, 2019, Vol.75 (Pt 4), pp.212-216IUCr
摘要:Decaprenyl diphosphate synthase from Mycobacterium tuberculosis (MtDPPS, also known as Rv2361c) catalyzes the consecutive elongation of ω,E,Z-farnesyl diphosphate (EZ-FPP) by seven isoprene units by forming new cis double bonds. The protein folds into a butterfly-like homodi...
作者:Jeffrey Ohren , Gwenn G. Parungao , Ronald E. Viola
来源:[J].Acta Crystallogr F Struct Biol Commun, 2019, Vol.75 (Pt 4), pp.290-298IUCr
摘要:S-Adenosyl-L-methionine (AdoMet), the primary methyl donor in most biological methylation reactions, is produced from ATP and methionine in a multistep reaction catalyzed by AdoMet synthetase. The diversity of group-transfer reactions that involve AdoMet places this compound at a...
作者:Robert H. Wilson , Manajit Hayer-Hartl , Andreas Bracher
来源:[J].Acta Crystallogr F Struct Biol Commun, 2019, Vol.75 (Pt 4), pp.278-289IUCr
摘要:Phosphoribulokinase (PRK) catalyses the ATP-dependent phosphorylation of ribulose 5-phosphate to give ribulose 1,5-bisphosphate. Regulation of this reaction in response to light controls carbon fixation during photosynthesis. Here, the crystal structure of PRK from the cyano...
作者:Athena Andreou , Petros Giastas , Sofia Arnaouteli ...
来源:[J].Acta Crystallogr F Struct Biol Commun, 2019, Vol.75 (Pt 4), pp.312-320IUCr
摘要:Ba0331 is a putative polysaccharide deacetylase from Bacillus anthracis, the etiological agent of the disease anthrax, that contributes to adaptation of the bacterium under extreme conditions and to maintenance of the cell shape. In the present study, the crystal structure o...
作者:Steven B. Larson , Jesse A. Jones , Alexander McPherson
来源:[J].Acta Crystallogr F Struct Biol Commun, 2019, Vol.75 (Pt 4), pp.217-226IUCr
摘要:An iron-containing alcohol dehydrogenase (FeADH) from the hyperthermophilic archaeon Thermococcus thioreducens was crystallized in unit cells belonging to space groups P2 1 , P2 1 2 1 2 1 and P4 3 2 1 2, and the crystal structures were solved at 2.4, 2.1 and 1.9 å res...
作者:Vinardas Kelpšas , Bénédicte Lafumat , Matthew P. Blakeley ...
来源:[J].Acta Crystallogr F Struct Biol Commun, 2019, Vol.75 (Pt 4), pp.260-269IUCr
摘要:Triose-phosphate isomerase (TIM) catalyses the interconversion of dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Two catalytic mechanisms have been proposed based on two reaction-intermediate analogues, 2-phosphoglycolate (2PG) and phosphoglycolohydroxamate (PGH), tha...
作者:Florian Bleffert , Joachim Granzin , Holger Gohlke ...
来源:[J].Acta Crystallogr F Struct Biol Commun, 2019, Vol.75 (Pt 4), pp.270-277IUCr
摘要:The human membrane-bound Α/Β-hydrolase domain 6 (ABHD6) protein modulates endocannabinoid signaling, which controls appetite, pain and learning, as well as being linked to Alzheimer's and Parkinson's diseases, through the degradation of the key lipid messenger 2-arachidonylg...
作者:Genady Pankov , Alice Dawson , William N. Hunter
来源:[J].Acta Crystallogr F Struct Biol Commun, 2019, Vol.75 (Pt 4), pp.227-232IUCr
摘要:The thick outer membrane (OM) of Gram-negative bacteria performs an important protective role against hostile environments, supports cell integrity, and contributes to surface adhesion and in some cases also to virulence. A major component of the OM is lipopolysaccharide (LPS), a...
作者:Rie Umeda , Tomohiro Nishizawa , Osamu Nureki
来源:[J].Acta Crystallogr F Struct Biol Commun, 2019, Vol.75 (Pt 4), pp.254-259IUCr
摘要:The tetraspanin family of proteins with four membrane-spanning proteins function in a wide range of physiological processes in higher organisms, including cell migration and proliferation, cell fusion, fertilization and virus infection. Although the recently reported structure of...
作者:Adam Hughes , Samuel Wilson , Eleanor J. Dodson ...
来源:[J].Acta Crystallogr F Struct Biol Commun, 2019, Vol.75 (Pt 4), pp.246-253IUCr
摘要:Peptides play an important signalling role in Bacillus subtilis, where their uptake by one of two ABC-type oligopeptide transporters, Opp and App, is required for efficient sporulation. Homologues of these transporters in Clostridium difficile have been characterized, but their r...

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