F1000 Research Ltd
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作者:Jonathan Nye , Daniël P. Melters , Yamini Dalal
来源:[J].F1000Research, 2018, Vol.7F1000 Research Ltd
摘要:Histone chaperones are indispensable regulators of chromatin structure and function. Recent work has shown that they are frequently mis-regulated in cancer, which can have profound consequences on tumor growth and survival. Here, we focus on chaperones for the essential H3 histon...
作者:Ayan Sengupta , Stefan Pollmann , Michael Hanke
来源:[J].F1000Research, 2018, Vol.7F1000 Research Ltd
摘要:Spatial filtering strategies, combined with multivariate decoding analysis of BOLD images, have been used to investigate the nature of the neural signal underlying the discriminability of brain activity patterns evoked by sensory stimulation -- primarily in the visual cortex. Rep...
作者:Jens Freese , Rainer Johannes Klement , Begoña Ruiz-Núñez ...
来源:[J].F1000Research, 2018, Vol.6F1000 Research Ltd
摘要:During the course of evolution, up until the agricultural revolution, environmental fluctuations forced the human species to develop a flexible metabolism in order to adapt its energy needs to various climate, seasonal and vegetation conditions. Metabolic flexibility safegua...
作者:Eleftherios P Diamandis , Nick Bouras
来源:[J].F1000Research, 2018, Vol.7F1000 Research Ltd
摘要:There has been an increasing awareness of the importance of leadership and decision making, including scientists and academics, over recent times. By whom and how decisions are made can have serious implications across all levels of society. Several people have been successful in...
作者:Christian Dallago , Tatyana Goldberg , Miguel Angel Andrade-Navarro ...
来源:[J].F1000Research, 2018, Vol.6F1000 Research Ltd
摘要:Many tools visualize protein-protein interaction (PPI) networks. The tool introduced here, CellMap, adds one crucial novelty by visualizing PPI networks in the context of subcellular localization, i.e. the location in the cell or cellular component in which a PPI happens. Users c...
作者:Mehdi Benchoufi , Raphael Porcher , Philippe Ravaud
来源:[J].F1000Research, 2018, Vol.6F1000 Research Ltd
摘要:Clinical trial consent for protocols and their revisions should be transparent for patients and traceable for stakeholders. Our goal is to implement a process allowing for collection of patients’ informed consent, which is bound to protocol revisions, storing and tracking th...
作者:Sean Johnson , Shin–ichiro Imai
来源:[J].F1000Research, 2018, Vol.7F1000 Research Ltd
摘要:Nicotinamide adenine dinucleotide (NAD+) biosynthesis and its regulation have recently been attracting markedly increasing interest. Aging is marked by a systemic decrease in NAD+ across multiple tissues. The dysfunction of NAD+ biosynthesis plays...
作者:Elizama de Gregorio , Dayanna Hartmann Cambruzzi Mendes , Luan Henrique Patrzyk ...
来源:[J].F1000Research, 2018, Vol.7F1000 Research Ltd
摘要:Introduction : Dementia is a common health problem in elderly people, Alzheimer disease (AD) being the most prevalent. AD can be considered as a cause of death and must be registered on the death certificate of the patients. However, most of the time, the main cause of death...
作者:Christian Ohmann , Steve Canham , Rita Banzi ...
来源:[J].F1000Research, 2018, Vol.7F1000 Research Ltd
摘要:Background: In recent years, a cultural change in the handling of data from research has resulted in the strong promotion of a culture of openness and increased sharing of data. In the area of clinical trials, sharing of individual participant data involves a complex set of proce...
作者:Joshua Powles , Kenton Ko
来源:[J].F1000Research, 2018, Vol.7F1000 Research Ltd
摘要:Background: Rhomboid serine proteases are present in many species with sequenced genomes, and are often encoded in each species by more than one predicted gene. Based on protein sequence comparisons, rhomboids can be differentiated into groups - secretases, presenilin-like a...

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