F1000 Research Ltd
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作者:Siobhan Crilly , Alexandra Njegic , Sarah E. Laurie ...
来源:[J].F1000Research, 2018, Vol.7F1000 Research Ltd
摘要:Intracerebral haemorrhage (ICH) is a devastating condition with limited treatment options, and current understanding of pathophysiology is incomplete. Spontaneous cerebral bleeding is a characteristic of the human condition that has proven difficult to recapitulate in existing pr...
作者:Yunshun Chen , Bhupinder Pal , Jane E. Visvader ...
来源:[J].F1000Research, 2018, Vol.6F1000 Research Ltd
摘要:Cytosine methylation is an important DNA epigenetic modification. In vertebrates, methylation occurs at CpG sites, which are dinucleotides where a cytosine is immediately followed by a guanine in the DNA sequence from 5' to 3'. When located in the promoter region of a gene, DNA m...
作者:Passant Nagi , Nevine Waly , Adel Elbardissy ...
来源:[J].F1000Research, 2018, Vol.7F1000 Research Ltd
摘要:Carious exposure of immature first permanent molar is a widespread issue faced in paediatric dentistry. This may be the result of the early eruption of this molar, so parents may think it is replicable to the rest of the deciduous teeth. Preserving pulp vitality is the primary go...
作者:Pooja Patel , Chinmayi Joshi , Snehal Funde ...
来源:[J].F1000Research, 2018, Vol.7F1000 Research Ltd
摘要:A Panchgavya preparation was evaluated for its prophylactic efficacy against bacterial infection, employing the nematode worm Caenorhabditis elegans as a model host. Worms fed with the Panchgavya preparation prior to being challenged with pathogenic bacteria had a better survival...
作者:Indranath Chatterjee
来源:[J].F1000Research, 2018, Vol.7F1000 Research Ltd
摘要:Background: Schizophrenia is a serious mental illness affecting different regions of the brain, which causes symptoms such as hallucinations and delusions. Functional magnetic resonance imaging (fMRI) is the most popular technique to study the functional activation patterns of th...
作者:James E. Johnson , Praveen Kumar , Caleb Easterly ...
来源:[J].F1000Research, 2018, Vol.7F1000 Research Ltd
摘要:Galaxy provides an accessible platform where multi-step data analysis workflows integrating disparate software can be run, even by researchers with limited programming expertise. Applications of such sophisticated workflows are many, including those which integrate software ...
作者:Lesley A. Schimanski , Juan Pablo Alperin
来源:[J].F1000Research, 2018, Vol.7F1000 Research Ltd
摘要:Review, promotion, and tenure (RPT) processes significantly affect how faculty direct their own career and scholarly progression. Although RPT practices vary between and within institutions, and affect various disciplines, ranks, institution types, genders, and ethnicity in diffe...
作者:Fatemeh Behjati Ardakani , Florian Schmidt , Marcel H. Schulz
来源:[J].F1000Research, 2018, Vol.7F1000 Research Ltd
摘要:Background : Understanding the location and cell-type specific binding of Transcription Factors (TFs) is important in the study of gene regulation. Computational prediction of TF binding sites is challenging, because TFs often bind only to short DNA motifs and cell-type specific ...
作者:Ana C. Londoño , Carlos A. Mora
来源:[J].F1000Research, 2018, Vol.7F1000 Research Ltd
摘要:Immunomodulatory therapies available for the treatment of patients with multiple sclerosis (MS) accomplish control and neutralization of peripheral immune cells involved in the activity of the disease cascade but their spectrum of action in the intrathecal space and brain tissue ...
作者:Shoaib Sufi , Caroline Jay
来源:[J].F1000Research, 2018, Vol.7F1000 Research Ltd
摘要:Background: This paper reports the results of an evaluation of the Software Sustainability Institute’s Fellowship Programme, which focused on identifying and categorising the benefits that the fellowship has afforded its recipients, via a series of open questions. Methods: T...

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