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作者:Estienne C. Swart , Cyril Denby Wilkes , Pamela Y. Sandoval ...
来源:[J].F1000Research, 2017, Vol.6F1000 Research Ltd
摘要:During development in the ciliate Paramecium, excess DNA interspersed throughout the germline genome is deleted to generate a new somatic genome. In this process, most of the intervening DNA is excised by a Piggybac-derived transposase, assisted by small RNAs (scnRNAs and iesRNAs...
作者:Courtney E. Chandler , Robert K. Ernst
来源:[J].F1000Research, 2017, Vol.6F1000 Research Ltd
摘要:The innate immune system serves as a first line of defense against microbial pathogens. The host innate immune response can be triggered by recognition of conserved non-self-microbial signature molecules by specific host receptor proteins called Toll-like receptors. For bacteria,...
作者:Gianluca Testa , Domenico Aloj , Alessandro Ghirri ...
来源:[J].F1000Research, 2017, Vol.6F1000 Research Ltd
摘要:Background : Femoral shaft fractures, typical in younger people, are often associated with polytrauma followed by traumatic shock. In these situations, despite intramedullary nailing being the treatment of choice, external fixation could be used as the definitive treatment. ...
作者:Kasey J. Day , Patrick J. La Rivière , Talon Chandler ...
来源:[J].F1000Research, 2017, Vol.6F1000 Research Ltd
摘要:Deconvolution is typically used to sharpen fluorescence images, but when the signal-to-noise ratio is low, the primary benefit is reduced noise and a smoother appearance of the fluorescent structures. 3D time-lapse (4D) confocal image sets can be improved by deconvolution. Howeve...
作者:Susan Guthrie , Ioana Ghiga , Steven Wooding
来源:[J].F1000Research, 2017, Vol.6F1000 Research Ltd
摘要:Background: Peer review decisions award >95% of academic medical research funding, so it is crucial to understand how well they work and if they could be improved. Methods: This paper summarises evidence from 105 relevant papers identified through a literature search on the ...
作者:Alistair Connell , Hugh Montgomery , Stephen Morris ...
来源:[J].F1000Research, 2017, Vol.6F1000 Research Ltd
摘要:Acute Kidney Injury (AKI), an abrupt deterioration in kidney function, is defined by changes in urine output or serum creatinine. AKI is common (affecting up to 20% of acute hospital admissions in the United Kingdom), associated with significant morbidity and mortality, and ...
作者:J. Jesús Naveja , José L. Medina-Franco
来源:[J].F1000Research, 2017, Vol.6F1000 Research Ltd
摘要:We present a novel approach called ChemMaps for visualizing chemical space based on the similarity matrix of compound datasets generated with molecular fingerprints’ similarity. The method uses a ‘satellites’ approach, where satellites are, in principle, molecules whose...
作者:Graham Pawelec
来源:[J].F1000Research, 2017, Vol.6F1000 Research Ltd
摘要:Like all somatic tissues, the human immune system changes with age. This is believed to result in an increased frequency of, and susceptibility to, infectious disease and to contribute to a wide range of non-communicable age-associated diseases in later life, especially cancer, c...
作者:Nicholas Bodnar , Tom Rapoport
来源:[J].F1000Research, 2017, Vol.6F1000 Research Ltd
摘要:A conserved AAA+ ATPase, called Cdc48 in yeast and p97 or VCP in metazoans, plays an essential role in many cellular processes by segregating polyubiquitinated proteins from complexes or membranes. For example, in endoplasmic reticulum (ER)-associated protein degradation (ERAD), ...
作者:Andrei Sourakov
来源:[J].F1000Research, 2017, Vol.6F1000 Research Ltd
摘要:Our knowledge of wing pattern formation in Lepidoptera has advanced significantly in recent years due to the careful examination of several groups of butterflies. The eyespot is a prominent feature of Lepidoptera wing pattern, especially in the family Saturniidae. The presen...

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