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作者:Juan Liu* , Changyan Li , Fang Gu
来源:[J].Advances in biology and medicine, 2018, Vol.3 (3)HCP
摘要:Abstract: The aim of this study was to investigate the effects of miR-206 on the proliferation and extracellular matrix (ECM) excessive accumulation of diabetic renal mesangial cells in mice with diabetic nephropathy. Mesangial cells (MCs) were cultured with high glucose to mimic...
作者:Hao Huang* , Yang Chen , Zhonghua Chen
来源:[J].Advances in biology and medicine, 2018, Vol.3 (3)HCP
摘要:Abstract Aim: This study aimed to explain the effects and mechanisms of microRNA-92a in gastric cancer. Methods: Thirty pairs of cancerous and adjacent normal tissues were collected from patients with gastric cancer. BCL2-interacting mediator of cell death (Bim) and miRNA-92...
作者:Yang Yang* , Jun Li
来源:[J].Advances in biology and medicine, 2018, Vol.3 (3)HCP
摘要:Abstract: miRNAs are rich in myocardial cells, involved in myocardial apoptosis, arrhythmia, myocardial hypertrophy and heart failure. In this study, we found that miRNA-21 over-expression had effects to improve myocardial pathology and myocardial apoptosis which induced by Ische...
作者:Lu Xiang* , Xi Xu , Xinxing Zhang
来源:[J].Advances in biology and medicine, 2018, Vol.3 (3)HCP
摘要:Abstract: Numerous studies have reported that miRNA-96 are involved in the development and progression of various types of human cancers. In the current study, the roles of miR-96 in colon cancer has been investigated. Human colon cancer cell line SW480 cells were transfecte...
作者:Lu Zhang , Changping Li* , Li Zhang
来源:[J].Advances in biology and medicine, 2018, Vol.3 (3)HCP
摘要:Abstract: Aim: The aim of this study was to explain the effect and mechanism of microRNA-375 in colon cancer. Methods: The HT29 and SW620 cells were respectively divided into 3 groups: NC group, BL group and miRNA group. We measured the cell proliferation, apoptosis and cell...
作者:Li Yang , Wancheng Li , Yu Zhou ...
来源:[J].Advances in biology and medicine, 2018, Vol.3 (2)HCP
摘要:Abstract: This study aimed to explore the molecular mechanism of miR-770 in NSCLC from the perspective of cell proliferation, invasion and migration. In this study, we found that the expression of miR-770 performed significantly decreased in NSCLC tissue compared to the adja...
作者:Ping You , Yiqiang Zhang , Huan Yin*
来源:[J].Advances in biology and medicine, 2018, Vol.3 (2)HCP
摘要:Abstract: Previous studies suggested that miR-146a expression was elevated in kidney biopsy and urine from nephropathy patients or rats. In this study, we investigated the possibility of urinary miR-146a as biomarker for diabetic nephropathy (DN) and its potential mechanism....
作者:Jingbo Li , Shuda Chen , Jing Meng ...
来源:[J].Advances in biology and medicine, 2018, Vol.3 (2)HCP
摘要:Abstract:Ischemic stroke is considered to be the leading cause of mortality and morbidity through the world. In the present study, we evaluated the role of miR-30b and its direct target, mixed lineage kinase 4 (MLK4), in ischemic stroke in an in vitro model. Murine microglia...
作者:Yingqiang Ren , Yong Yang , Yuanfang Pu*
来源:[J].Advances in biology and medicine, 2018, Vol.3 (2)HCP
摘要:Abstract: miRNA-221 was a carcinogenic factor in many cancers, however, it is limited that the correlation between miRNA-221 and progression of cervical cancer. So we here aimed to determine the function of miRNA-221 in cervical cancer proliferation and apoptosis. Interestingly, ...
作者:Bin Yan* , Yi Gan , Fang Cao
来源:[J].Advances in biology and medicine, 2018, Vol.3 (2)HCP
摘要:Abstract:Diabetic nephropathy is a common complication of type 2 diabetes mellitus. Production of reactive oxygen species (ROS) caused by hyperglycemia is associated with fibrosis. The aim of this research is to investigate the role of calreticulin (CRT), an endoplasmic reti...

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