PubMed期刊
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作者:Ali Idress , Alahdal Murad , Xia Haifa ...
来源:[J].The Libyan journal of medicine, 2020, Vol.15 (1), pp.1688450PubMed
摘要:Background : Emergence agitation is a reformed state of mindfulness, which starts with a sudden form of anesthesia and progresses through the early repossession age. Thus, the purpose of this study is to evaluate 1:3 ketofol performance on children 3-15 years old undergoing adeno...
作者:Kontonasaki Eleana , Giasimakopoulos Panagiotis , Rigos Athanasios E
来源:[J].The Japanese dental science review, 2020, Vol.56 (1), pp.1-23PubMed
摘要:New zirconia compositions with optimized esthetic properties have emerged due to the fast-growing technology in zirconia manufacturing. However, the large variety of commercial products and synthesis routes, make impossible to include all of them under the general term of "monoli...
作者:Shen Qing-Kun , Gong Guo-Hua , Li Gao- ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.85-95PubMed
摘要:To develop novel anti-inflammatory agents, a series of 5-alkyl-4-oxo-4,5-dihydro-[1, 2, 4]triazolo[4,3-a]quinoxaline-1-carboxamide derivatives were designed, synthesised, and evaluated for anti-inflammatory effects using RAW264.7 cells. Structures of the synthesised compound...
作者:Dokmak Amr , Radwan Amr , Halpin Meredith ...
来源:[J].Medical education online, 2020, Vol.25 (1), pp.1686950PubMed
摘要:The internal medicine In-Training Exam (ITE) is administered at residency training programs to assess medical knowledge. Our internal medicine residency program witnessed a performance decline on the ITE between 2011 and 2014. The goal of this quality improvement project was...
作者:Hong Dong Jin , Jung Seung Hyun , Kim Jisook ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.227-234PubMed
摘要:A novel series of thieno[3,2- d ]pyrimidine derivatives were synthesised and their inhibitory effects against diacylglycerol acyltransferase 1 (DGAT-1) were assessed. cis-Isomer 17a showed potent and selective inhibitory activity against DGAT-1 in SF9 cells. In addition, 17a had ...
作者:Fancellu Gaia , Chand Karam , Tomás Daniel ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.211-226PubMed
摘要:Pursuing the widespread interest on multi-target drugs to combat Alzheimer´s disease (AD), a new series of hybrids was designed and developed based on the repositioning of the well-known acetylcholinesterase (AChE) inhibitor, tacrine (TAC), by its coupling to benzofuran (BF)...
作者:Krasavin Mikhail , Kalinin Stanislav , Zozulya Sergey ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.165-171PubMed
摘要:Testing of an expanded, 800-compound set of analogues of the earlier described Strecker-type α-aminonitriles (selected from publicly available Enamine Ltd. Screening Collection) in thermal shift assay against bovine carbonic anhydrase ( b CA) led to further validation of thi...
作者:Martínez de Iturrate Paula , Sebastián-Pérez Victor , Nácher-Vázquez Montserrat ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.199-210PubMed
摘要:Previous reports have validated the glycogen synthase kinase-3 (GSK-3) as a druggable target against the human protozoan parasite Leishmania . This prompted us to search for new leishmanicidal scaffolds as inhibitors of this enzyme from our in-house library of human GSK-3β i...
作者:Liu Wandong , Hou Caiyun , Li Jiaming ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.187-198PubMed
摘要:Twenty novel talmapimod analogues were designed, synthesised and evaluated for the in vivo anti-inflammatory activities. Among them, compound 6n , the most potent one, was selected for exploring the mechanisms underlying its anti-inflammatory efficacy. In RAW264.7 cells, it ...
作者:Stephenson Christopher R , Qian Qi , Mueller Paul S ...
来源:[J].Medical education online, 2020, Vol.25 (1), pp.1694308PubMed
摘要:Background : Industry funding in continuing medical education has been extensively studied in the USA. Although continuing medical education is also a requirement for Chinese physicians, little is known about Chinese physician perceptions of industry support in continuing medical...

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