作者:Yuka Hirakawa, Aika Okuno, Daisaku Kimura, Takashi Okuwa, Fukumi Furukawa
来源:[J].Trends in Immunotherapy, 2017, Vol.1 (3)EnPress Publisher
摘要:Discoid lupus erythematosus (DLE) is an autoimmune disorder that usually occurs on sun exposed areas. We describe a case of a 31-year-old man with reddish-purple, atrophic plaques on the nose and the bilateral cheeks. Histopathologic and direct immuneofluorescent studies confirme...
作者:Akihiro Aioi
来源:[J].Trends in Immunotherapy, 2017, Vol.1 (3)EnPress Publisher
摘要:Sirtuins (SIRTs) are initially recognized as NAD+-dependent histone deacetylase. SIRTs attract attention for their role as calorie restriction-induced longevity proteins to be expected to extend human life span and to promote health. As advancing studies, SIRTs have been recogniz...
作者:Wei Boon Yap, Shaktypreya Nadarajah, Nadiah Shidik, Noorjahan Banu Mohammed Alitheen
来源:[J].Trends in Immunotherapy, 2017, Vol.1 (3)EnPress Publisher
摘要:Cancer immunotherapy using cytokines has been sought as an alternative therapeutic approach for treating cancers. Besides remarkable immunoregulatory properties, interleukin (IL)-27 has recently been shown to possess promising anticancer functions; hence, its potential roles in c...
作者:Tamer Fakhry, Mohamed Shawky
来源:[J].Journal of Pediatric Diseases, 2017, Vol.1EnPress Publisher
摘要:Appendicitis is the most common cause of emergency abdominal surgeries in children. Ultrasound (US) has been proven to be a helpful imaging modality in patient evaluation, especially in children suspected of appendicitis. The Alvarado score is a 10-point scoring system for the di...
作者:Satoshi Nakamizo, Tetsuya Honda, Kenji Kabashima
来源:[J].Trends in Immunotherapy, 2017, Vol.1 (2)EnPress Publisher
摘要:Obesity has become a significant public health problem since it may cause many chronic diseases, including type 2 diabetes, cardiovascular diseases, liver diseases, and some cancers. Recent studies have shown that obesity is a major risk factor for the development of inflammatory...
作者:Mana Nishiguchi, Fukumi Furukawa, Takaharu Ikeda
来源:[J].Trends in Immunotherapy, 2017, Vol.1 (2)EnPress Publisher
摘要:A 74-year-old woman noticed an edematous erythema on the right upper eyelid two months before her first medical examination, and slight fever, arthralgia and edematous erythema on the forearms and palms around the time of the first medical examination. She presented with typ...
作者:Naoya Mikita, Yutaka Inaba, Takashi Yoshimasu, Nobuo Kanazawa, Fukumi Furukawa
来源:[J].Trends in Immunotherapy, 2017, Vol.1 (2)EnPress Publisher
摘要:Mast cells are involved in many immune reactions and diseases through 1) the expressions of several receptors, 2) productions of various mediators such as histamine, cytokines, and chemokines, 3) direct interactions with immune cells. Besides allergic diseases, mast cells have be...
作者:Naoki Kondo, Osamu Tanifuji, Tomoharu Mochizuki, Yosuke Sudo, Naoto Endo
来源:[J].Trends in Immunotherapy, 2017, Vol.1 (2)EnPress Publisher
摘要:A 45–year–old male suffered from persistent swelling and redness, with pain in his left lower leg and ankle. Pathological findings isolated from the ankle joint by arthroscopic synovectomy showed mild synovitis. Initially, this case was diagnosed as chronic mild arthritis an...


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