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作者:Ewa Forma , Paweł Jóźwiak , Piotr Ciesielski ...
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (6)PLOS
摘要:Enhancer of zest homolog 2 (EZH2) is a histone methyltransferase which plays a crucial role in cancer progression by regulation of genes involved in cellular processes such as proliferation, invasion and self-renewal. Activity and biological function of EZH2 are regulated by post...
作者:Marije A. van Melle , Henk F. van Stel , Judith M. Poldervaart ...
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (6)PLOS
摘要:Patients are at risk for harm when treated simultaneously by healthcare providers from different healthcare organisations. To assess current practice and improvements of transitional patient safety, valid measurement tools are needed.;;To identify and appraise all measurement too...
作者:Mai Hashimoto , Kazuaki Taguchi , Takako Ishiguro ...
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (6)PLOS
摘要:4′-cyano-2′-deoxyinosine (SK14-061a), a novel nucleoside analog based on inosine, has antiviral activity against the human immunodeficiency virus type 1 that has the ability to acquire resistance against many types of reverse transcriptase inhibitors based on nucleosides. Th...
作者:Nikolas Schrod , Dimitri Vanhecke , Ulrike Laugks ...
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (6)PLOS
摘要:Many cellular processes depend on a precise structural organization of molecular components. Here, we established that neurons grown in culture provide a suitable system for in situ structural investigations of cellular structures by cryo-electron tomography, a method that allows...
作者:Wei Liu , Qin Li , Hui Li ...
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (6)PLOS
摘要:To examine the 20-year trends in the combined prevalence of overweight and obesity among children aged 0–6 years between 1995 and 2015 in Harbin, China, we selected altogether 49,553 children aged 0–6 years old by using a multistage stratified cluster sampling methods in Har...
作者:Anna Schneider , Matthias Weigl
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (6)PLOS
摘要:Emergency departments (ED) are complex and dynamic work environments with various psychosocial work stressors that increase risks for providers’ well-being. Yet, no systematic review is available which synthesizes the current research base as well as quantitatively aggregate...
作者:Ambrin Sarwar , Günter Brader , Erika Corretto ...
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (6)PLOS
摘要:Bacillus spp. produce a broad spectrum of lipopeptide biosurfactants, among which surfactin, iturin and fengycin are widely studied families. The goals of this study were to characterize the biosurfactant activity of Bacillus spp. and to investigate their motility and biofilm for...
作者:Lottie W. Stipdonk , Marie-Christine J. P. Franken , Jeroen Dudink
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (6)PLOS
摘要:Preterm children often have language problems. This atypical language development is probably due to atypical brain development. We conducted a systematic review to provide an overview of the extensive and diverse scientific literature on the relations between language outcome an...
作者:Lin Yang , Ai Koyanagi , Lee Smith ...
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (6)PLOS
摘要:We evaluated the associations of handgrip strength and cognitive function in cancer survivors ≥ 60 years old using data from the National Health and Nutrition Examination Survey (NHANES).;;Data in two waves of NHANES (2011–2014) were aggregated. Handgrip strength in kilogram...
作者:Phirangkul Kerdpanich , Pornthep Chanthavanich , Mari Rose De Los Reyes ...
来源:[J].PLOS Neglected Tropical Diseases(IF 4.569), 2018, Vol.12 (6)PLOS
摘要:This phase III clinical trial compared the immunogenicity and safety of a purified chick-embryo cell rabies vaccine (PCECV) administered according to a shortened post-exposure prophylaxis (PEP) 4-site/1-week intradermal regimen, compared with the currently recommended 2-site...

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