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作者:Wataru Sato , Chie Furuta , Keiko Matsunaga ...
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (8)PLOS
摘要:Ready-to-use therapeutic food (RUTF) is used to treat children suffering from severe acute malnutrition (SAM). Standard RUTF uses milk as the primary protein source, which makes the product expensive, and given the high worldwide SAM burden, having a less expensive effective...
作者:Suzanne A. B. M. Aarts , Myrthe E. Reiche , Myrthe den Toom ...
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (8)PLOS
摘要:Obesity is a low-grade inflammatory disease that increases the risk for metabolic disorders. CD40-CD40L signaling plays a central role in obesity-induced inflammation. Genetic deficiency of CD40L in diet-induced obesity (DIO) ameliorates adipose tissue inflammation, hepatic steat...
作者:Athanasios Samaras , Michail Pavlidis
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (8)PLOS
摘要:Mechanisms regulating differences in cortisol responsiveness between low (LR) and high response (HR) individuals have been poorly studied. In this context, we aimed to study key regulatory processes in cortisol dynamics at the head kidneys of LR and HR European sea bass. To ...
作者:Yun Liu , Qingxia Kong , Shasha Yuan ...
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (8)PLOS
摘要:In China, patients increasingly choose to access already severely overcrowded higher level hospitals, leaving lower level facilities with low utilization rates. This situation undermines the effectiveness and efficiency of the health system. The situation tends to worsen des...
作者:Lik Hang N. Lee , Ric M. Procyshyn , Randall F. White ...
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (8)PLOS
摘要:Retrospective data were collected from 330 individuals who were treated at a tertiary care program for treatment-resistant psychosis between 1994 and 2010. The main objectives were to compare the use of antipsychotic monotherapy to polypharmacy and to characterize within-individu...
作者:Teresa Katthagen , Christoph Mathys , Lorenz Deserno ...
来源:[J].PLOS Computational Biology(IF 5.215), 2018, Vol.14 (8)PLOS
摘要:In schizophrenia, increased aberrant salience to irrelevant events and reduced learning of relevant information may relate to an underlying deficit in relevance detection. So far, subjective estimates of relevance have not been probed in schizophrenia patients. The mechanisms und...
作者:Kenneth Allen Dyar , Michaël Jean Hubert , Ashfaq Ali Mir ...
来源:[J].PLOS Biology(IF 11.452), 2018, Vol.16 (8)PLOS
摘要:Circadian clocks are fundamental physiological regulators of energy homeostasis, but direct transcriptional targets of the muscle clock machinery are unknown. To understand how the muscle clock directs rhythmic metabolism, we determined genome-wide binding of the master cloc...
作者:B. P. Mallikarjuna Swamy , Gwen Iris L. Descalsota , Chau Thanh Nha ...
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (8)PLOS
摘要:Rice provides energy and nutrition to more than half of the world’s population. Breeding rice varieties with the increased levels of bioavailable micronutrients is one of the most sustainable approaches to tackle micronutrient malnutrition. So, high zinc and iron content in ...
作者:Mohanalakshmi Narasumani , Paul M. Harrison
来源:[J].PLOS Computational Biology(IF 5.215), 2018, Vol.14 (8)PLOS
摘要:Intrinsically disordered regions (IDRs) of proteins play significant biological functional roles despite lacking a well-defined 3D structure. For example, IDRs provide efficient housing for large numbers of post-translational modification (PTM) sites in eukaryotic proteins. ...

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