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作者:Yuerong Wang , Shuangshuang Wei , Lintao Chen ...
来源:[J].PLOS ONE(IF 3.73), 2017, Vol.12 (11)PLOS
摘要:Troxerutin, a semi-synthetic derivative of the natural bioflavanoid rutin, has been reported to possess many beneficial effects in human bodies, such as vasoprotection, immune support, anti-inflammation and anti-aging. However, the effects of troxerutin on genome-wide transcripti...
作者:Kjersti Daae Horvei , Hege Lynum Pedersen , Silje Fismen ...
来源:[J].PLOS ONE(IF 3.73), 2017, Vol.12 (11)PLOS
摘要:FcγRIIB-/-yaa mice develop severe lupus glomerulonephritis due to lack of an inhibitory immune cell receptor combined with a Y-chromosome linked autoimmune accelerator mutation. In the present study, we have investigated nephritis development and progression in Fc...
作者:Zilca Campos , Guilherme Mourão , William E. Magnusson
来源:[J].PLOS ONE(IF 3.73), 2017, Vol.12 (11)PLOS
摘要:Run-of-the-river hydroelectric dams cause changes in seasonal inundation of the floodplains, and this may cause displacement of semi-aquatic vertebrates present before dam construction. This study evaluated the movement of crocodilians before and after the filling of the San...
作者:Debi M. Thomas , Brandon Bell , Stephanie Papillon ...
来源:[J].PLOS ONE(IF 3.73), 2017, Vol.12 (11)PLOS
摘要:Necrotizing enterocolitis (NEC) is a significant cause of morbidity and mortality in premature infants; yet its pathogenesis remains poorly understood. To evaluate the role of intestinal bacteria in protection against NEC, we assessed the ability of naturally occurring intestinal...
作者:Yuki Nagata , Tohru Kiyono , Kikuo Okamura ...
来源:[J].PLOS ONE(IF 3.73), 2017, Vol.12 (12)PLOS
摘要:Duchenne muscular dystrophy (DMD) is a severe X-linked recessive muscle disorder caused by mutations in the dystrophin gene. Nonetheless, secondary processes involving perturbation of muscle regeneration probably exacerbate disease progression, resulting in the fatal loss of...
作者:Anthony Basilio , Steven Searcy , Andrew R. Thompson
来源:[J].PLOS ONE(IF 3.73), 2017, Vol.12 (11)PLOS
摘要:The West Coast of the United States experienced variable and sometimes highly unusual oceanographic conditions between 2012 and 2015. In particular, a warm mass of surface water known as the Pacific Warm Anomaly (popularly as “The Blob”) impinged on southern California in 20...
作者:Laura J. James , Germaine Wong , Jonathan C. Craig ...
来源:[J].PLOS ONE(IF 3.73), 2017, Vol.12 (11)PLOS
摘要:Prostate cancer is the most commonly diagnosed non-skin cancer in men. Screening for prostate cancer is widely accepted; however concerns regarding the harms outweighing the benefits of screening exist. Although patient’s play a pivotal role in the decision making process, m...
作者:Shuo Liu , Xiaoqiang Liu , Shuying Chen ...
来源:[J].PLOS ONE(IF 3.73), 2017, Vol.12 (11)PLOS
摘要:Intravenous glucocorticoids are recommended for multiple sclerosis (MS). However, they can be inconvenient and expensive. Due to their convenience and low cost, oral glucocorticoids may be an alternative treatment. Recently, several studies have shown that there is no differ...
作者:Guangming Xu , Shuo Zhao , Feng Shi ...
来源:[J].PLOS ONE(IF 3.73), 2017, Vol.12 (11)PLOS
摘要:For urban rail transit network, the space-time flow distribution can play an important role in evaluating and optimizing the space-time resource allocation. For obtaining the space-time flow distribution without the restriction of schedules, a dynamic assignment problem is propos...
作者:Norbert Pfeiffer , Bogomil Voykov , Giulia Renieri ...
来源:[J].PLOS ONE(IF 3.73), 2017, Vol.12 (11)PLOS
摘要:To evaluate the safety and tolerability of intravitreal ISTH0036, an antisense oligonucleotide selectively targeting transforming growth factor beta 2 (TGF-β2), in patients with primary open angle glaucoma (POAG) undergoing trabeculectomy (TE; glaucoma filtration surgery).;;...

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