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作者:Emilie J. Richards , Christopher H. Martin
来源:[J].PLOS Genetics(IF 8.694), 2017, Vol.13 (8)PLOS
摘要:Rapid diversification often involves complex histories of gene flow that leave variable and conflicting signatures of evolutionary relatedness across the genome. Identifying the extent and source of variation in these evolutionary relationships can provide insight into the evolut...
作者:Alyssa C. Meyers , Marvin Meinders , Sarah A. Hamer
来源:[J].PLOS Neglected Tropical Diseases(IF 4.569), 2017, Vol.11 (8)PLOS
摘要:Chagas disease, caused by the vector-borne protozoan Trypanosoma cruzi , is increasingly recognized in the southern U.S. Government-owned working dogs along the Texas-Mexico border could be at heightened risk due to prolonged exposure outdoors in habitats with high densities...
作者:Mihir Vohra , George A. Lemieux , Lin Lin ...
来源:[J].PLOS Biology(IF 11.452), 2017, Vol.15 (8)PLOS
摘要:In species ranging from humans to Caenorhabditis elegans , dietary restriction (DR) grants numerous benefits, including enhanced learning. The precise mechanisms by which DR engenders benefits on processes related to learning remain poorly understood. As a result, it is uncl...
作者:Tao Chen , Bas van Steensel
来源:[J].PLOS Genetics(IF 8.694), 2017, Vol.13 (8)PLOS
摘要:Eukaryotic mRNAs undergo a cycle of transcription, nuclear export, and degradation. A major challenge is to obtain a global, quantitative view of these processes. Here we measured the genome-wide nucleocytoplasmic dynamics of mRNA in Drosophila cells by metabolic labeling in comb...
作者:Belma Melda Abidin , Akil Hammami , Simona Stäger ...
来源:[J].PLOS Pathogens(IF 9.127), 2017, Vol.13 (8)PLOS
摘要:Cells of the immune system are derived from hematopoietic stem cells (HSCs) residing in the bone marrow. HSCs become activated in response to stress, such as acute infections, which adapt the bone marrow output to the needs of the immune response. However, the impact of infection...
作者:Alexander V. Maltsev , Victor A. Maltsev , Michael D. Stern
来源:[J].PLOS Computational Biology(IF 5.215), 2017, Vol.13 (8)PLOS
摘要:Intracellular Local Ca releases (LCRs) from sarcoplasmic reticulum (SR) regulate cardiac pacemaker cell function by activation of electrogenic Na/Ca exchanger (NCX) during diastole. Prior studies demonstrated the existence of powerful compensatory mechanisms of LCR regulation via...
作者:John Kinsman , Kars de Bruijne , Alpha M. Jalloh ...
来源:[J].PLOS Neglected Tropical Diseases(IF 4.569), 2017, Vol.11 (8)PLOS
摘要:The West African Ebola epidemic of 2013–2016 was by far the largest outbreak of the disease on record. Sierra Leone suffered nearly half of the 28,646 reported cases. This paper presents a set of culturally contextualized Ebola messages that are based on the findings of qual...
作者:Chunhong Cheng , Zhijuan Wang , Ziyin Ren ...
来源:[J].PLOS Genetics(IF 8.694), 2017, Vol.13 (8)PLOS
摘要:The phytohormone abscisic acid (ABA) is an essential part of the plant response to abiotic stressors such as drought. Upon the perception of ABA, pyrabactin resistance (PYR)/PYR1-like (PYL)/regulatory components of ABA receptor (RCAR) proteins interact with co-receptor protein ph...

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