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作者:Pilar I Beato-Víbora PhD, Francisco J Arroyo-Díez PhD
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:Hypoglycaemia is the more frequent complication of insulin therapy and the main barrier to tight glycaemic control. Injectable glucagon and oral intake of carbohydrates are the recommended treatments for severe and non-severe hypoglycaemia episodes, respectively. Nasal glucagon i...
作者:Brian Ford MD, Alex McDonald MD, Shilpa Srinivasan MD, DFAPA
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:Anti-N-methyl D-aspartate (NMDA) receptor (anti-NMDAR) encephalitis is among one of the most common autoimmune encephalitides. However, variations in clinical presentation and nonsequential multiphasic course often lead to delays in diagnosis. The mild encephalitis (ME) hypothesi...
作者:Daniela Barraco MD, Margherita Maffioli MD, Francesco Passamonti MD
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:Myelofibrosis (MF) is a heterogeneous disorder characterized by splenomegaly, constitutional symptoms, ineffective hematopoiesis, and an increased risk of leukemic transformation. The ongoing research in understanding the pathophysiology of the disease has allowed for the develop...
作者:Marco Caminati MD, Francesco Menzella MD, Lucia Guidolin MD, Gianenrico Senna MD
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:Recent research in the field of bronchial asthma has mainly focused on eosinophilic disease phenotype. Several trials proved the efficacy and safety profile of eosinophils and interleukin (IL)-5 targeting molecules, currently approved for severe asthma and available on the market...
作者:Nicolò Martinelli MD, Vincenzo Curci MD, Antonella Quarantiello MD, Gennaro Saldalamacchia MD
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:This article is the first part of a literature review concerning diabetic foot ulcers and the use of antimicrobial photodynamic therapy (PDT). Diabetic foot ulcers are associated with high morbidity, mortality, and healthcare costs. Natural healing is often delayed by microbial i...
作者:Matteo Bassetti MD, PhD, Daniele Roberto Giacobbe MD, Antonio Vena MD, PhD, Adrian Brink MMed
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:Antimicrobial stewardship programmes have been playing an important role in patient care and hospital policies. These programmes are now recognised as formal strategies for curbing the upward trend in antibiotic resistance and for improving the appropriate antimicrobial and antif...
作者:Francesco Serra MD, Pietro Lapidari MD, Erica Quaquarini MD, Barbara Tagliaferri MD, Federico Sottotetti MD, Raffaella Palumbo MD, PhD
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:The purpose of this review is to summarize the background and latest evidence for the use of palbociclib, an oral, first-in-class, highly selective cyclin-dependent kinase 4/6 inhibitor, in advanced breast cancer, with a focus on some of the unanswered questions about the pe...
作者:Rudolf Hoermann, John E M Midgley, Rolf Larisch, Johannes W Dietrich
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:Levothyroxine (LT4) therapy has a long history, a well-defined pharmacological profile and a favourable safety record in the alleviation of hypothyroidism. However, questions remain in defining the threshold for the requirement of treatment in patients with subclinical hypothyroi...
作者:Kanae Jennifer Nagao MBBS (Hons), FRACP, Neepa J Patel MD
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson’s disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestin...
作者:Jan Kestřánek MD
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:Hemorrhoids are commonly reported in women. However, despite the high prevalence of hemorrhoids in women and the major impact of this condition on quality of life, specific evidence and recommendations on the treatment of hemorrhoids in women are scant. This paper reviews va...

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