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Design principles of a microtubule polymerase
作者：Elisabeth A Geyer , Matthew P Miller , Chad A Brautigam ...
来源：[J].eLife, 2018, Vol.7eLife科学出版社
摘要：Stu2/XMAP215 microtubule polymerases use multiple tubulin-binding TOG domains and a lattice-binding basic region to processively promote faster elongation. How the domain composition and organization of these proteins dictate polymerase activity, end localization, and proces...
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    Chiral cell sliding drives left-right asymmetric organ twisting
    作者：Mikiko Inaki , Ryo Hatori , Naotaka Nakazawa ...
    来源：[J].eLife, 2018, Vol.7eLife科学出版社
    摘要：Polarized epithelial morphogenesis is an essential process in animal development. While this process is mostly attributed to directional cell intercalation, it can also be induced by other mechanisms. Using live-imaging analysis and a three-dimensional vertex model, we ident...
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      Connectomics of the zebrafish's lateral-line neuromast reveals wiring and miswiring in a simple microcircuit
      作者：Eliot Dow , Adrian Jacobo , Sajjad Hossain ...
      来源：[J].eLife, 2018, Vol.7eLife科学出版社
      摘要：The lateral-line neuromast of the zebrafish displays a restricted, consistent pattern of innervation that facilitates the comparison of microcircuits across individuals, developmental stages, and genotypes. We used serial blockface scanning electron microscopy to determine from m...
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        Dynamics of ribosomes and release factors during translation termination in E. coli
        作者：Sarah Adio , Heena Sharma , Tamara Senyushkina ...
        来源：[J].eLife, 2018, Vol.7eLife科学出版社
        摘要：Release factors RF1 and RF2 promote hydrolysis of peptidyl-tRNA during translation termination. The GTPase RF3 promotes recycling of RF1 and RF2. Using single molecule FRET and biochemical assays, we show that ribosome termination complexes that carry two factors, RF1–RF3 or...
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          Journal clubs in the time of preprints
          作者：Prachee Avasthi , Alice Soragni , Joshua N Bembenek
          来源：[J].eLife, 2018, Vol.7eLife科学出版社
          摘要：Early-career researchers can learn about peer review by discussing preprints at journal clubs and sending feedback to the authors.
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            Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy
            作者：Timothy F Miles , Katja Spiess , Kevin M Jude ...
            来源：[J].eLife, 2018, Vol.7eLife科学出版社
            摘要：Human cytomegalovirus has hijacked and evolved a human G-protein-coupled receptor into US28, which functions as a promiscuous chemokine 'sink’ to facilitate evasion of host immune responses. To probe the molecular basis of US28’s unique ligand cross-reactivity, we deep-seque...
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              Leading the charge
              作者：Andrew JR Plested
              来源：[J].eLife, 2018, Vol.7eLife科学出版社
              摘要：A simple label-free method uses the electrical properties of cells to detect how ligands bind to membrane proteins.
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                Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors
                作者：Divyanshu Malhotra , Jimann Shin , Lilianna Solnica-Krezel ...
                来源：[J].eLife, 2018, Vol.7eLife科学出版社
                摘要：Chemokines are secreted proteins that regulate a range of processes in eukaryotic organisms. Interestingly, different chemokine receptors control distinct biological processes, and the same receptor can direct different cellular responses, but the basis for this phenomenon i...
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                  The cell sets the tone
                  作者：Jonna Alanko , Michael Sixt
                  来源：[J].eLife, 2018, Vol.7eLife科学出版社
                  摘要：In zebrafish larvae, it is the cell type that determines how the cell responds to a chemokine signal.
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                    PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis
                    作者：Genevieve C Kendall , Sarah Watson , Lin Xu ...
                    来源：[J].eLife, 2018, Vol.7eLife科学出版社
                    摘要：Alveolar rhabdomyosarcoma is a pediatric soft-tissue sarcoma caused by PAX3/7-FOXO1 fusion oncogenes and is characterized by impaired skeletal muscle development. We developed human PAX3-FOXO1 -driven zebrafish models of tumorigenesis and found that PAX3-FOXO1 exhibits discr...
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