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作者:Chelsea Hepler , Bo Shan , Qianbin Zhang ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:White adipose tissue (WAT) remodeling is dictated by coordinated interactions between adipocytes and resident stromal-vascular cells; however, the functional heterogeneity of adipose stromal cells has remained unresolved. We combined single-cell RNA-sequencing and FACS to id...
作者:Stefano Musardo , Camilla Bellone
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Being exposed to cannabinoids in the womb has different consequences for male and female rats.
作者:Tineke Grent-'t-Jong , Joachim Gross , Jozien Goense ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients and 34 chronic ScZ-patients. Furthermore, MRS-data were...
作者:Stephanie C Seeman , Luke Campagnola , Pasha A Davoudian ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Generating a comprehensive description of cortical networks requires a large-scale, systematic approach. To that end, we have begun a pipeline project using multipatch electrophysiology, supplemented with two-photon optogenetics, to characterize connectivity and synaptic signalin...
作者:Julius Judd , Cédric Feschotte
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:A family of retroviral-like elements in the human genome has a pervasive influence on gene expression.
作者:Fernando Rodríguez-Pérez , Michael Rape
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:A transcription factor called SALL4 could be the missing link between thalidomide and the limb defects caused by the drug.
作者:Brian T Emmer , Geoffrey G Hesketh , Emilee Kotnik ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:PCSK9 is a secreted protein that regulates plasma cholesterol levels and cardiovascular disease risk. Prior studies suggested the presence of an ER cargo receptor that recruits PCSK9 into the secretory pathway, but its identity has remained elusive. Here, we apply a novel approac...
作者:Senjuti Saha , Sudipta Saha , Samir K Saha
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Research laboratories in low- and middle-income countries, where the global burden of disease is highest, face systemic challenges in conducting research and public health surveillance. An international effort is needed to overcome the paywalls, customs regulations and lack of lo...
作者:Zoé Vincent-Mistiaen , Ahmed Elbediwy , Hannah Vanyai ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Squamous cell carcinoma (SCC) can progress to malignant metastatic cancer, including an aggressive subtype known as spindle cell carcinoma (spSCC). spSCC formation involves epithelial-to-mesenchymal transition (EMT), yet the molecular basis of this event remains unknown. The tran...
作者:John B Lees-Shepard , Sarah-Anne E Nicholas , Sean J Stoessel ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by debilitating heterotopic ossification (HO). The retinoic acid receptor gamma agonist, palovarotene, and antibody-mediated activin A blockade have entered human clinical trials, but how th...

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