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Epistasis and entrenchment of drug resistance in HIV-1 subtype B
作者：Avik Biswas , Allan Haldane , Eddy Arnold ...
来源：[J].eLife, 2019, Vol.8eLife科学出版社
摘要：The development of drug resistance in HIV is the result of primary mutations whose effects on viral fitness depend on the entire genetic background, a phenomenon called ‘epistasis’. Based on protein sequences derived from drug-experienced patients in the Stanford HIV databas...
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    Stereotyped transcriptomic transformation of somatosensory neurons in response to injury
    作者：Minh Q Nguyen , Claire E Le Pichon , Nicholas Ryba
    来源：[J].eLife, 2019, Vol.8eLife科学出版社
    摘要：In mice, spared nerve injury replicates symptoms of human neuropathic pain and induces upregulation of many genes in somatosensory neurons. Here we used single cell transcriptomics to probe the effects of partial infraorbital transection of the trigeminal nerve at the cellular le...
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      Olfactory connectivity mediates sleep-dependent food choices in humans
      作者：Surabhi Bhutani , James D Howard , Rachel Reynolds ...
      来源：[J].eLife, 2019, Vol.8eLife科学出版社
      摘要：Sleep deprivation has marked effects on food intake, shifting food choices toward energy-dense options. Here we test the hypothesis that neural processing in central olfactory circuits, in tandem with the endocannabinoid system (ECS), plays a key role in mediating this relat...
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        Pretectal neurons control hunting behaviour
        作者：Paride Antinucci , Mónica Folgueira , Isaac H Bianco
        来源：[J].eLife, 2019, Vol.8eLife科学出版社
        摘要：For many species, hunting is an innate behaviour that is crucial for survival, yet the circuits that control predatory action sequences are poorly understood. We used larval zebrafish to identify a population of pretectal neurons that control hunting. By combining calcium im...
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          A primal role for the vestibular sense in the development of coordinated locomotion
          作者：David E Ehrlich , David Schoppik
          来源：[J].eLife, 2019, Vol.8eLife科学出版社
          摘要：Mature locomotion requires that animal nervous systems coordinate distinct groups of muscles. The pressures that guide the development of coordination are not well understood. To understand how and why coordination might emerge, we measured the kinematics of spontaneous vertical ...
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            Looking into nerve damage in the cornea
            作者：Mihaela Gadjeva
            来源：[J].eLife, 2019, Vol.8eLife科学出版社
            摘要：Interactions between T helper cells and the complement system promote loss of sensory neurons in the eye.
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              Embryo polarity in moth flies and mosquitoes relies on distinct old genes with localized transcript isoforms
              作者：Yoseop Yoon , Jeff Klomp , Ines Martin-Martin ...
              来源：[J].eLife, 2019, Vol.8eLife科学出版社
              摘要：Unrelated genes establish head-to-tail polarity in embryos of different fly species, raising the question of how they evolve this function. We show that in moth flies ( Clogmia , Lutzomyia ), a maternal transcript isoform of odd-paired (Zic) is localized in the anterior egg ...
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                Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA
                作者：Míriam Javier-Torrent , Sergi Marco , Daniel Rocandio ...
                来源：[J].eLife, 2019, Vol.8eLife科学出版社
                摘要：EphA/ephrin signaling regulates axon growth and guidance of neurons, but whether this process occurs also independently of ephrins is unclear. We show that presenilin-1 (PS1)/γ-secretase is required for axon growth in the developing mouse brain. PS1/γ-secretase mediates axon...
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                  Hemozoin produced by mammals confers heme tolerance
                  作者：Rini H Pek , Xiaojing Yuan , Nicole Rietzschel ...
                  来源：[J].eLife, 2019, Vol.8eLife科学出版社
                  摘要：Free heme is cytotoxic as exemplified by hemolytic diseases and genetic deficiencies in heme recycling and detoxifying pathways. Thus, intracellular accumulation of heme has not been observed in mammalian cells to date. Here we show that mice deficient for the heme transporter SL...
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                    How flies turn food into progeny
                    作者：Thomas Flatt
                    来源：[J].eLife, 2019, Vol.8eLife科学出版社
                    摘要：Sex-optimal diets have different effects on gene expression in female and male flies.
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