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作者:Hannah P Savage , Kathrin Kläsener , Fauna L Smith ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:In mice, neonatally-developing, self-reactive B-1 cells generate steady levels of natural antibodies throughout life. B-1 cells can, however, also rapidly respond to infections with increased local antibody production. The mechanisms regulating these two seemingly very distinct f...
作者:Lieselotte SM Kreuk , Meghan A Koch , Leianna C Slayden ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:B-1a cells play an important role in mediating tissue homeostasis and protecting against infections. They are the main producers of ‘natural’ IgM, spontaneously secreted serum antibodies predominately reactive to self antigens, like phosphatidylcholine (PtC), or antigens exp...
作者:Johann Mignolet , Guillaume Cerckel , Julien Damoczi ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Constantly surrounded by kin or alien organisms in nature, eukaryotes and prokaryotes developed various communication systems to coordinate adaptive multi-entity behavior. In complex and overcrowded environments, they require to discriminate relevant signals in a myriad of pherom...
作者:Brooke Morriswood , Oliver Hoeller
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:The fact that it is difficult to evaluate and compare the outputs of individual researchers might actually be good for science.
作者:Rosa María Marión , Juan J Montero , Isabel López de Silanes ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:The mechanisms that regulate pluripotency are still largely unknown. Here, we show that Telomere Repeat Binding Factor 1 (TRF1), a component of the shelterin complex, regulates the genome-wide binding of polycomb and polycomb H3K27me3 repressive marks to pluripotency genes, ...
作者:Lu Yu , Valerie P O'Brien , Jonathan Livny ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:A mucosal infectious disease episode can render the host either more or less susceptible to recurrent infection, but the specific mechanisms that tip the balance remain unclear. We investigated this question in a mouse model of recurrent urinary tract infection and found tha...
作者:Amy M LeMessurier , Keven J Laboy-Juárez , Kathryn McClain ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Sensory maps in layer (L) 2/3 of rodent cortex lack precise functional column boundaries, and instead exhibit locally heterogeneous (salt-and-pepper) tuning superimposed on smooth global topography. Could this organization be a byproduct of impoverished experience in laboratory h...
作者:Evan Witt , Sigi Benjamin , Nicolas Svetec ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:The testis is a peculiar tissue in many respects. It shows patterns of rapid gene evolution and provides a hotspot for the origination of genetic novelties such as de novo genes, duplications and mutations. To investigate the expression patterns of genetic novelties across cell t...
作者:George L Sutphin
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Young Caenorhabditis elegans hermaphrodites use their own sperm to protect against the negative consequences of mating.

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