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Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA
作者：Ruben Soto-Acosta , Xuping Xie , Chao Shan ...
来源：[J].eLife, 2018, Vol.7eLife科学出版社
摘要：Subgenomic flaviviral RNA (sfRNA) accumulates during infection due to incomplete degradation of viral genomes and interacts with cellular proteins to promote infection. Here we identify host proteins that bind the Zika virus (ZIKV) sfRNA. We identified fragile X mental retardatio...
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    Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth
    作者：Martina Rudnicki , Ghoncheh Abdifarkosh , Emmanuel Nwadozi ...
    来源：[J].eLife, 2018, Vol.7eLife科学出版社
    摘要：Impaired angiogenesis is a hallmark of metabolically dysfunctional adipose tissue in obesity. However, the underlying mechanisms restricting angiogenesis within this context remain ill-defined. Here, we demonstrate that induced endothelial-specific depletion of the transcription ...
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      Separating the present and the future
      作者：Qing Yu , Bradley R Postle
      来源：[J].eLife, 2018, Vol.7eLife科学出版社
      摘要：The brain stores information that is needed immediately and information that will be needed in the future in different ways.
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        Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2
        作者：Mario Ruiz , Rakesh Bodhicharla , Emma Svensk ...
        来源：[J].eLife, 2018, Vol.7eLife科学出版社
        摘要：Dietary fatty acids are the main building blocks for cell membranes in animals, and mechanisms must therefore exist that compensate for dietary variations. We isolated C. elegans mutants that improved tolerance to dietary saturated fat in a sensitized genetic background, inc...
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          Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis
          作者：Stephin J Vervoort , Olivier G de Jong , M Guy Roukens ...
          来源：[J].eLife, 2018, Vol.7eLife科学出版社
          摘要：The expression of the transcription factor SOX4 is increased in many human cancers, however, the pro-oncogenic capacity of SOX4 can vary greatly depending on the type of tumor. Both the contextual nature and the mechanisms underlying the pro-oncogenic SOX4 response remain unexplo...
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            How does social enrichment produce health benefits?
            作者：Takefumi Kikusui
            来源：[J].eLife, 2018, Vol.7eLife科学出版社
            摘要：Oxytocin appears to link social interaction and cell aging in rats, especially in females.
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              Rejection of immunogenic tumor clones is limited by clonal fraction
              作者：Ron S Gejman , Aaron Y Chang , Heather F Jones ...
              来源：[J].eLife, 2018, Vol.7eLife科学出版社
              摘要：Tumors often co-exist with T cells that recognize somatically mutated peptides presented by cancer cells on major histocompatibility complex I (MHC-I). However, it is unknown why the immune system fails to eliminate immune-recognizable neoplasms before they manifest as frank...
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                Correction: Visualizing conformational dynamics of proteins in solution and at the cell membrane
                作者：Sharona E Gordon , Mika Munari , William N Zagotta
                来源：[J].eLife, 2018, Vol.7eLife科学出版社
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                  Revealing the secrets of secretion
                  作者：Antony Galione , Lianne C Davis
                  来源：[J].eLife, 2018, Vol.7eLife科学出版社
                  摘要：An intracellular ion channel may have a central role in the release of cytokines by macrophages.
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                    A novel enhancer near the Pitx1 gene influences development and evolution of pelvic appendages in vertebrates
                    作者：Abbey C Thompson , Terence D Capellini , Catherine A Guenther ...
                    来源：[J].eLife, 2018, Vol.7eLife科学出版社
                    摘要：Vertebrate pelvic reduction is a classic example of repeated evolution. Recurrent loss of pelvic appendages in sticklebacks has previously been linked to natural mutations in a pelvic enhancer that maps upstream of Pitx1 . The sequence of this upstream PelA enhancer is not conser...
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