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作者:Martin H Berryer , Sara G Kosmaczewski , Lindy E Barrett
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Experiments on flies suggest that a gain-of-function mechanism in a protein called CSPɑ contributes to the progressive brain disease CLN4.
作者:Menghao Lu , Kota Mizumoto
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:During development, the nervous system undergoes a refinement process by which neurons initially extend an excess number of neurites, the majority of which will be eliminated by the mechanism called neurite pruning. Some neurites undergo stereotyped and developmentally regulated ...
作者:Raffaele Tucciarelli , Moritz Wurm , Elisa Baccolo ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Categorizing and understanding other people’s actions is a key human capability. Whereas there exists a growing literature regarding the organization of objects, the representational space underlying the organization of observed actions remains largely unexplored. Here we ex...
作者:Luisa F Pallares
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Rare genetic variants in yeast explain a large amount of phenotypic variation in a complex trait like growth.
作者:Andrew R McKinstry-Wu , Andrzej Z Wasilczuk , Benjamin A Harrison ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Traditionally, drug dosing is based on a concentration-response relationship estimated in a population. Yet, in specific individuals, decisions based on the population-level effects frequently result in over or under-dosing. Here, we interrogate the relationship between populatio...
作者:Elias T Friman , Cédric Deluz , Antonio CA Meireles-Filho ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:The pioneer activity of transcription factors allows for opening of inaccessible regulatory elements and has been extensively studied in the context of cellular differentiation and reprogramming. In contrast, the function of pioneer activity in self-renewing cell divisions and ac...
作者:Allison M Owen , Samir P Patel , Jeffrey D Smith ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Chronic critical illness is a global clinical issue affecting millions of sepsis survivors annually. Survivors report chronic skeletal muscle weakness and development of new functional limitations that persist for years. To delineate mechanisms of sepsis-induced chronic weakness,...
作者:Raphael M Bendriem , Shawn Singh , Alice Abdel Aleem ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Occludin ( OCLN ) mutations cause human microcephaly and cortical malformation. A tight junction component thought absent in neuroepithelium after neural tube closure, OCLN isoform-specific expression extends into corticogenesis. Full-length and truncated isoforms localize to neu...
作者:Carla Verna , Sree Janani Ravichandran , Megan G Sawchuk ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Plants coordinate the polarity of hundreds of cells during vein formation, but how they do so is unclear. The prevailing hypothesis proposes that GNOM, a regulator of membrane trafficking, positions PIN-FORMED auxin transporters to the correct side of the plasma membrane; th...
作者:Cynthia B Silveira , Antoni Luque , Ty NF Roach ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:The microbialization of coral reefs predicts that microbial oxygen consumption will cause reef deoxygenation. Here we tested this hypothesis by analyzing reef microbial and primary producer oxygen metabolisms. Metagenomic data and in vitro incubations of bacteria with primary pro...

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