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TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections
作者：Hannah P Savage , Kathrin Kläsener , Fauna L Smith ...
来源：[J].eLife, 2019, Vol.8eLife科学出版社
摘要：In mice, neonatally-developing, self-reactive B-1 cells generate steady levels of natural antibodies throughout life. B-1 cells can, however, also rapidly respond to infections with increased local antibody production. The mechanisms regulating these two seemingly very distinct f...
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    B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota
    作者：Lieselotte SM Kreuk , Meghan A Koch , Leianna C Slayden ...
    来源：[J].eLife, 2019, Vol.8eLife科学出版社
    摘要：B-1a cells play an important role in mediating tissue homeostasis and protecting against infections. They are the main producers of ‘natural’ IgM, spontaneously secreted serum antibodies predominately reactive to self antigens, like phosphatidylcholine (PtC), or antigens exp...
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      Subtle selectivity in a pheromone sensor triumvirate desynchronizes competence and predation in a human gut commensal
      作者：Johann Mignolet , Guillaume Cerckel , Julien Damoczi ...
      来源：[J].eLife, 2019, Vol.8eLife科学出版社
      摘要：Constantly surrounded by kin or alien organisms in nature, eukaryotes and prokaryotes developed various communication systems to coordinate adaptive multi-entity behavior. In complex and overcrowded environments, they require to discriminate relevant signals in a myriad of pherom...
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        Hidden value
        作者：Brooke Morriswood , Oliver Hoeller
        来源：[J].eLife, 2019, Vol.8eLife科学出版社
        摘要：The fact that it is difficult to evaluate and compare the outputs of individual researchers might actually be good for science.
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          TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2
          作者：Rosa María Marión , Juan J Montero , Isabel López de Silanes ...
          来源：[J].eLife, 2019, Vol.8eLife科学出版社
          摘要：The mechanisms that regulate pluripotency are still largely unknown. Here, we show that Telomere Repeat Binding Factor 1 (TRF1), a component of the shelterin complex, regulates the genome-wide binding of polycomb and polycomb H3K27me3 repressive marks to pluripotency genes, ...
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            Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence
            作者：Lu Yu , Valerie P O'Brien , Jonathan Livny ...
            来源：[J].eLife, 2019, Vol.8eLife科学出版社
            摘要：A mucosal infectious disease episode can render the host either more or less susceptible to recurrent infection, but the specific mechanisms that tip the balance remain unclear. We investigated this question in a mouse model of recurrent urinary tract infection and found tha...
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              Oral transfer of chemical cues, growth proteins and hormones in social insects
              作者：Adria C LeBoeuf , Patrice Waridel , Colin S Brent ...
              来源：[J].eLife, 2019, Vol.8eLife科学出版社
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                Enrichment drives emergence of functional columns and improves sensory coding in the whisker map in L2/3 of mouse S1
                作者：Amy M LeMessurier , Keven J Laboy-Juárez , Kathryn McClain ...
                来源：[J].eLife, 2019, Vol.8eLife科学出版社
                摘要：Sensory maps in layer (L) 2/3 of rodent cortex lack precise functional column boundaries, and instead exhibit locally heterogeneous (salt-and-pepper) tuning superimposed on smooth global topography. Could this organization be a byproduct of impoverished experience in laboratory h...
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                  Testis single-cell RNA-seq reveals the dynamics of de novo gene transcription and germline mutational bias in Drosophila
                  作者：Evan Witt , Sigi Benjamin , Nicolas Svetec ...
                  来源：[J].eLife, 2019, Vol.8eLife科学出版社
                  摘要：The testis is a peculiar tissue in many respects. It shows patterns of rapid gene evolution and provides a hotspot for the origination of genetic novelties such as de novo genes, duplications and mutations. To investigate the expression patterns of genetic novelties across cell t...
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                    A new defense in the battle of the sexes
                    作者：George L Sutphin
                    来源：[J].eLife, 2019, Vol.8eLife科学出版社
                    摘要：Young Caenorhabditis elegans hermaphrodites use their own sperm to protect against the negative consequences of mating.
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