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A branched heterochronic pathway directs juvenile-to-adult transition through two LIN-29 isoforms
一个分支的异慢性途径通过两个LIN-29异构体直接引导幼年到成年的过渡
作者：Chiara Azzi , Florian Aeschimann , Anca Neagu ...
来源：[J].eLife, 2020, Vol.9
摘要：Robust organismal development relies on temporal coordination of disparate physiological processes. In Caenorhabditis elegans , the heterochronic pathway controls a timely juvenile-to-adult (J/A) transition. This regulatory cascade of conserved proteins and small RNAs culminates ...
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    Co-evolution within structured bacterial communities results in multiple expansion of CRISPR loci and enhanced immunity
    结构化细菌群落内的协同进化导致CRISPR位点的多次扩展，免疫力增强
    作者：Nora C Pyenson , Luciano A Marraffini
    来源：[J].eLife, 2020, Vol.9
    摘要：Type II CRISPR-Cas systems provide immunity against phages and plasmids that infect bacteria through the insertion of a short sequence from the invader’s genome, known as the ‘spacer’, into the CRISPR locus. Spacers are transcribed into guide RNAs that direct the Cas9 n...
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      Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios
      将克隆动力学与dN / dS比值相结合，测量适应效应在体细胞进化中的分布
      作者：Marc J Williams , Luis Zapata , Benjamin Werner ...
      来源：[J].eLife, 2020, Vol.9
      摘要：The distribution of fitness effects (DFE) defines how new mutations spread through an evolving population. The ratio of non-synonymous to synonymous mutations (dN/dS) has become a popular method to detect selection in somatic cells. However the link, in somatic evolution, be...
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        Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth
        果蝇TRIM32与糖酵解酶协同促进细胞生长
        作者：Simranjot Bawa , David S Brooks , Kathryn E Neville ...
        来源：[J].eLife, 2020, Vol.9
        摘要：Cell growth and/or proliferation may require the reprogramming of metabolic pathways, whereby a switch from oxidative to glycolytic metabolism diverts glycolytic intermediates towards anabolic pathways. Herein, we identify a novel role for TRIM32 in the maintenance of glycolytic ...
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          Prediction signals in the cerebellum: beyond supervised motor learning
          小脑预测信号：超监督运动学习
          作者：Court Hull
          来源：[J].eLife, 2020, Vol.9
          摘要：While classical views of cerebellar learning have suggested that this structure predominantly operates according to an error-based supervised learning rule to refine movements, emerging evidence suggests that the cerebellum may also harness a wider range of learning rules to cont...
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            An adaptable defense
            适应性防御
            作者：Michael A Schelling , Dipali G Sashital
            来源：[J].eLife, 2020, Vol.9
            摘要：The response of bacteria to the threat posed by phages depends on their local environment.
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              Mitigating the impact of conference and travel cancellations on researchers’ futures
              缓解会议和旅行取消对研究者未来的影响
              作者：Tracey Weissgerber , Yaw Bediako , Charlotte M de Winde ...
              来源：[J].eLife, 2020, Vol.9
              摘要：The need to protect public health during the current COVID-19 pandemic has necessitated conference cancellations on an unprecedented scale. As the scientific community adapts to new working conditions, it is important to recognize that some of our actions may disproportionately a...
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                Publishing in the time of COVID-19
                COVID-19时代出版
                作者：Michael B Eisen , Anna Akhmanova , Timothy E Behrens ...
                来源：[J].eLife, 2020, Vol.9
                摘要：eLife is making changes to its policies on peer review in response to the impact of COVID-19 on the scientific community.
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                  Exerting an influence on evolution
                  对进化产生影响
                  作者：Charles C Roseman
                  来源：[J].eLife, 2020, Vol.9
                  摘要：Experiments on mice have shown that developmental processes are influencing the generation of phenotypic variation in a way that shapes evolution.
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                    Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour
                    识别狭缝3作为影响斑马鱼尼古丁偏好和人类吸烟行为的位点
                    作者：Judit García-González , Alistair J Brock , Matthew O Parker ...
                    来源：[J].eLife, 2020, Vol.9
                    摘要：To facilitate smoking genetics research we determined whether a screen of mutagenized zebrafish for nicotine preference could predict loci affecting smoking behaviour. From 30 screened F3 sibling groups, where each was derived from an individual ethyl-nitrosurea mutage...
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