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Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice
作者：Chelsea Hepler , Bo Shan , Qianbin Zhang ...
来源：[J].eLife, 2018, Vol.7eLife科学出版社
摘要：White adipose tissue (WAT) remodeling is dictated by coordinated interactions between adipocytes and resident stromal-vascular cells; however, the functional heterogeneity of adipose stromal cells has remained unresolved. We combined single-cell RNA-sequencing and FACS to id...
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    What does cannabis do to the brain before birth?
    作者：Stefano Musardo , Camilla Bellone
    来源：[J].eLife, 2018, Vol.7eLife科学出版社
    摘要：Being exposed to cannabinoids in the womb has different consequences for male and female rats.
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      Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages
      作者：Tineke Grent-'t-Jong , Joachim Gross , Jozien Goense ...
      来源：[J].eLife, 2018, Vol.7eLife科学出版社
      摘要：We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients and 34 chronic ScZ-patients. Furthermore, MRS-data were...
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        Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex
        作者：Stephanie C Seeman , Luke Campagnola , Pasha A Davoudian ...
        来源：[J].eLife, 2018, Vol.7eLife科学出版社
        摘要：Generating a comprehensive description of cortical networks requires a large-scale, systematic approach. To that end, we have begun a pipeline project using multipatch electrophysiology, supplemented with two-photon optogenetics, to characterize connectivity and synaptic signalin...
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          Transposons take remote control
          作者：Julius Judd , Cédric Feschotte
          来源：[J].eLife, 2018, Vol.7eLife科学出版社
          摘要：A family of retroviral-like elements in the human genome has a pervasive influence on gene expression.
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            Unlocking a dark past
            作者：Fernando Rodríguez-Pérez , Michael Rape
            来源：[J].eLife, 2018, Vol.7eLife科学出版社
            摘要：A transcription factor called SALL4 could be the missing link between thalidomide and the limb defects caused by the drug.
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              The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9
              作者：Brian T Emmer , Geoffrey G Hesketh , Emilee Kotnik ...
              来源：[J].eLife, 2018, Vol.7eLife科学出版社
              摘要：PCSK9 is a secreted protein that regulates plasma cholesterol levels and cardiovascular disease risk. Prior studies suggested the presence of an ER cargo receptor that recruits PCSK9 into the secretory pathway, but its identity has remained elusive. Here, we apply a novel approac...
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                Barriers in Bangladesh
                作者：Senjuti Saha , Sudipta Saha , Samir K Saha
                来源：[J].eLife, 2018, Vol.7eLife科学出版社
                摘要：Research laboratories in low- and middle-income countries, where the global burden of disease is highest, face systemic challenges in conducting research and public health surveillance. An international effort is needed to overcome the paywalls, customs regulations and lack of lo...
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                  YAP drives cutaneous squamous cell carcinoma formation and progression
                  作者：Zoé Vincent-Mistiaen , Ahmed Elbediwy , Hannah Vanyai ...
                  来源：[J].eLife, 2018, Vol.7eLife科学出版社
                  摘要：Squamous cell carcinoma (SCC) can progress to malignant metastatic cancer, including an aggressive subtype known as spindle cell carcinoma (spSCC). spSCC formation involves epithelial-to-mesenchymal transition (EMT), yet the molecular basis of this event remains unknown. The tran...
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                    Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity
                    作者：John B Lees-Shepard , Sarah-Anne E Nicholas , Sean J Stoessel ...
                    来源：[J].eLife, 2018, Vol.7eLife科学出版社
                    摘要：Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by debilitating heterotopic ossification (HO). The retinoic acid receptor gamma agonist, palovarotene, and antibody-mediated activin A blockade have entered human clinical trials, but how th...
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