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作者:Daniel M Parker , Sai Thein Than Tun , Lisa J White ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:The global malaria burden has decreased over the last decade and many nations are attempting elimination. Asymptomatic malaria infections are not normally diagnosed or treated, posing a major hurdle for elimination efforts. One solution to this problem is mass drug administration...
作者:Yu-Lingzi Zhou , Adam Ślipiński , Dong Ren ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Complex interspecies relationships are widespread among metazoans, but the evolutionary history of these lifestyles is poorly understood. We describe a fossil beetle in 99-million-year-old Burmese amber that we infer to have been a social impostor of the earliest-known ant c...
作者:Andrew K Lawton , Tyler Engstrom , Daniel Rohrbach ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Models based in differential expansion of elastic material, axonal constraints, directed growth, or multi-phasic combinations have been proposed to explain brain folding. However, the cellular and physical processes present during folding have not been defined. We used the murine...
作者:Meredith A Sommars , Krithika Ramachandran , Madhavi D Senagolage ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Transcription is tightly regulated to maintain energy homeostasis during periods of feeding or fasting, but the molecular factors that control these alternating gene programs are incompletely understood. Here, we find that the B cell lymphoma 6 (BCL6) repressor is enriched i...
作者:Stephanie T Kuwahara , Maxwell A Serowoky , Venus Vakhshori ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Most bones in mammals display a limited capacity for natural large-scale repair. The ribs are a notable exception, yet the source of their remarkable regenerative ability remains unknown. Here, we identify a Sox9 -expressing periosteal subpopulation that orchestrates large-scale ...
作者:Nicolas J Lehrbach , Gary Ruvkun
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Unfolded protein responses (UPRs) safeguard cellular function during proteotoxic stress and aging. In a previous paper (Lehrbach and Ruvkun, 2016) we showed that the ER-associated SKN-1A/Nrf1 transcription factor activates proteasome subunit expression in response to proteas...
作者:Hirofumi Noguchi , Jesse Garcia Castillo , Kinichi Nakashima ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Adult hippocampal neurogenesis requires the quiescent neural stem cell (NSC) pool to persist lifelong. However, establishment and maintenance of quiescent NSC pools during development is not understood. Here, we show that Suppressor of Fused (Sufu) controls establishment of the q...
作者:André Longtin
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Electric fish are able to take what they have learnt about sensory processing in certain situations and apply it in other situations.
作者:Elizabeth A Mueller , Alexander JF Egan , Eefjan Breukink ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Although the peptidoglycan cell wall is an essential structural and morphological feature of most bacterial cells, the extracytoplasmic enzymes involved in its synthesis are frequently dispensable under standard culture conditions. By modulating a single growth parameter—ext...
作者:Simeon Leupold , Georg Hubmann , Athanasios Litsios ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:A comprehensive description of the phenotypic changes during cellular aging is key towards unraveling its causal forces. Previously, we mapped age-related changes in the proteome and transcriptome (Janssens et al., 2015). Here, employing the same experimental procedure and model-...

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