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Cellular tolerance at the µ-opioid receptor is phosphorylation dependent
作者：Seksiri Arttamangkul , Daniel A Heinz , James R Bunzow ...
来源：[J].eLife, 2018, Vol.7eLife科学出版社
摘要：Phosphorylation of the μ-opioid receptor (MOR) is known as a key step in desensitization and internalization but the role in the development of long-term tolerance at the cellular level is not known. Viral expression of wild type (exWT) and mutant MORs, where all phosphoryla...
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    Cherub versus brat
    作者：Jennifer A Malin , Claude Desplan
    来源：[J].eLife, 2018, Vol.7eLife科学出版社
    摘要：A long non-coding RNA molecule called cherub is a driver of tumor development.
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      Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites
      作者：Adam J Reid , Arthur M Talman , Hayley M Bennett ...
      来源：[J].eLife, 2018, Vol.7eLife科学出版社
      摘要：Single-cell RNA-sequencing is revolutionising our understanding of seemingly homogeneous cell populations but has not yet been widely applied to single-celled organisms. Transcriptional variation in unicellular malaria parasites from the Plasmodium genus is associated with c...
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        The kinetoplastid-infecting Bodo saltans virus (BsV), a window into the most abundant giant viruses in the sea
        作者：Christoph M Deeg , Cheryl-Emiliane T Chow , Curtis A Suttle
        来源：[J].eLife, 2018, Vol.7eLife科学出版社
        摘要：Giant viruses are ecologically important players in aquatic ecosystems that have challenged concepts of what constitutes a virus. Herein, we present the giant Bodo saltans virus (BsV), the first characterized representative of the most abundant group of giant viruses in ocea...
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          High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1
          作者：Douglas Maya Miles , Xenia Peñate , Trinidad Sanmartín Olmo ...
          来源：[J].eLife, 2018, Vol.7eLife科学出版社
          摘要：Whole-genome duplications (WGDs) have played a central role in the evolution of genomes and constitute an important source of genome instability in cancer. Here, we show in Saccharomyces cerevisiae that abnormal accumulations of histones are sufficient to induce WGDs. Our results...
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            How early-career researchers are shaping eLife
            作者：Mark Patterson , Randy Schekman
            来源：[J].eLife, 2018, Vol.7eLife科学出版社
            摘要：Initiatives to improve research communication can benefit from listening to graduate students, postdocs and newly-independent group leaders.
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              Origin and evolution of the nuclear auxin response system
              作者：Sumanth K Mutte , Hirotaka Kato , Carl Rothfels ...
              来源：[J].eLife, 2018, Vol.7eLife科学出版社
              摘要：The small signaling molecule auxin controls numerous developmental processes in land plants, acting mostly by regulating gene expression. Auxin response proteins are represented by large families of diverse functions, but neither their origin nor their evolution is understood. He...
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                The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells
                作者：Lisa Landskron , Victoria Steinmann , Francois Bonnay ...
                来源：[J].eLife, 2018, Vol.7eLife科学出版社
                摘要：Tumor cells display features that are not found in healthy cells. How they become immortal and how their specific features can be exploited to combat tumorigenesis are key questions in tumor biology. Here we describe the long non-coding RNA cherub that is critically required...
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                  Occurrence of long-term depression in the cerebellar flocculus during adaptation of optokinetic response
                  作者：Takuma Inoshita , Tomoo Hirano
                  来源：[J].eLife, 2018, Vol.7eLife科学出版社
                  摘要：Long-term depression (LTD) at parallel fiber (PF) to Purkinje cell (PC) synapses has been considered as a main cellular mechanism for motor learning. However, the necessity of LTD for motor learning was challenged by demonstration of normal motor learning in the LTD-defective ani...
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                    Pauses in cholinergic interneuron firing exert an inhibitory control on striatal output in vivo
                    作者：Stefano Zucca , Aya Zucca , Takashi Nakano ...
                    来源：[J].eLife, 2018, Vol.7eLife科学出版社
                    摘要：The cholinergic interneurons (CINs) of the striatum are crucial for normal motor and behavioral functions of the basal ganglia. Striatal CINs exhibit tonic firing punctuated by distinct pauses. Pauses occur in response to motivationally significant events, but their function...
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