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作者:Ruben Soto-Acosta , Xuping Xie , Chao Shan ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Subgenomic flaviviral RNA (sfRNA) accumulates during infection due to incomplete degradation of viral genomes and interacts with cellular proteins to promote infection. Here we identify host proteins that bind the Zika virus (ZIKV) sfRNA. We identified fragile X mental retardatio...
作者:Martina Rudnicki , Ghoncheh Abdifarkosh , Emmanuel Nwadozi ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Impaired angiogenesis is a hallmark of metabolically dysfunctional adipose tissue in obesity. However, the underlying mechanisms restricting angiogenesis within this context remain ill-defined. Here, we demonstrate that induced endothelial-specific depletion of the transcription ...
作者:Qing Yu , Bradley R Postle
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:The brain stores information that is needed immediately and information that will be needed in the future in different ways.
作者:Mario Ruiz , Rakesh Bodhicharla , Emma Svensk ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Dietary fatty acids are the main building blocks for cell membranes in animals, and mechanisms must therefore exist that compensate for dietary variations. We isolated C. elegans mutants that improved tolerance to dietary saturated fat in a sensitized genetic background, inc...
作者:Stephin J Vervoort , Olivier G de Jong , M Guy Roukens ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:The expression of the transcription factor SOX4 is increased in many human cancers, however, the pro-oncogenic capacity of SOX4 can vary greatly depending on the type of tumor. Both the contextual nature and the mechanisms underlying the pro-oncogenic SOX4 response remain unexplo...
作者:Takefumi Kikusui
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Oxytocin appears to link social interaction and cell aging in rats, especially in females.
作者:Ron S Gejman , Aaron Y Chang , Heather F Jones ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Tumors often co-exist with T cells that recognize somatically mutated peptides presented by cancer cells on major histocompatibility complex I (MHC-I). However, it is unknown why the immune system fails to eliminate immune-recognizable neoplasms before they manifest as frank...
作者:Antony Galione , Lianne C Davis
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:An intracellular ion channel may have a central role in the release of cytokines by macrophages.
作者:Abbey C Thompson , Terence D Capellini , Catherine A Guenther ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Vertebrate pelvic reduction is a classic example of repeated evolution. Recurrent loss of pelvic appendages in sticklebacks has previously been linked to natural mutations in a pelvic enhancer that maps upstream of Pitx1 . The sequence of this upstream PelA enhancer is not conser...

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