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Fly model sheds light on brain disease
作者：Martin H Berryer , Sara G Kosmaczewski , Lindy E Barrett
来源：[J].eLife, 2019, Vol.8eLife科学出版社
摘要：Experiments on flies suggest that a gain-of-function mechanism in a protein called CSPɑ contributes to the progressive brain disease CLN4.
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    Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans
    作者：Menghao Lu , Kota Mizumoto
    来源：[J].eLife, 2019, Vol.8eLife科学出版社
    摘要：During development, the nervous system undergoes a refinement process by which neurons initially extend an excess number of neurites, the majority of which will be eliminated by the mechanism called neurite pruning. Some neurites undergo stereotyped and developmentally regulated ...
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      The representational space of observed actions
      作者：Raffaele Tucciarelli , Moritz Wurm , Elisa Baccolo ...
      来源：[J].eLife, 2019, Vol.8eLife科学出版社
      摘要：Categorizing and understanding other people’s actions is a key human capability. Whereas there exists a growing literature regarding the organization of objects, the representational space underlying the organization of observed actions remains largely unexplored. Here we ex...
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        Searching for solutions to the missing heritability problem
        作者：Luisa F Pallares
        来源：[J].eLife, 2019, Vol.8eLife科学出版社
        摘要：Rare genetic variants in yeast explain a large amount of phenotypic variation in a complex trait like growth.
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          Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia
          作者：Andrew R McKinstry-Wu , Andrzej Z Wasilczuk , Benjamin A Harrison ...
          来源：[J].eLife, 2019, Vol.8eLife科学出版社
          摘要：Traditionally, drug dosing is based on a concentration-response relationship estimated in a population. Yet, in specific individuals, decisions based on the population-level effects frequently result in over or under-dosing. Here, we interrogate the relationship between populatio...
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            Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle
            作者：Elias T Friman , Cédric Deluz , Antonio CA Meireles-Filho ...
            来源：[J].eLife, 2019, Vol.8eLife科学出版社
            摘要：The pioneer activity of transcription factors allows for opening of inaccessible regulatory elements and has been extensively studied in the context of cellular differentiation and reprogramming. In contrast, the function of pioneer activity in self-renewing cell divisions and ac...
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              Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model
              作者：Allison M Owen , Samir P Patel , Jeffrey D Smith ...
              来源：[J].eLife, 2019, Vol.8eLife科学出版社
              摘要：Chronic critical illness is a global clinical issue affecting millions of sepsis survivors annually. Survivors report chronic skeletal muscle weakness and development of new functional limitations that persist for years. To delineate mechanisms of sepsis-induced chronic weakness,...
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                Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex
                作者：Raphael M Bendriem , Shawn Singh , Alice Abdel Aleem ...
                来源：[J].eLife, 2019, Vol.8eLife科学出版社
                摘要：Occludin ( OCLN ) mutations cause human microcephaly and cortical malformation. A tight junction component thought absent in neuroepithelium after neural tube closure, OCLN isoform-specific expression extends into corticogenesis. Full-length and truncated isoforms localize to neu...
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                  Coordination of tissue cell polarity by auxin transport and signaling
                  作者：Carla Verna , Sree Janani Ravichandran , Megan G Sawchuk ...
                  来源：[J].eLife, 2019, Vol.8eLife科学出版社
                  摘要：Plants coordinate the polarity of hundreds of cells during vein formation, but how they do so is unclear. The prevailing hypothesis proposes that GNOM, a regulator of membrane trafficking, positions PIN-FORMED auxin transporters to the correct side of the plasma membrane; th...
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                    Biophysical and physiological processes causing oxygen loss from coral reefs
                    作者：Cynthia B Silveira , Antoni Luque , Ty NF Roach ...
                    来源：[J].eLife, 2019, Vol.8eLife科学出版社
                    摘要：The microbialization of coral reefs predicts that microbial oxygen consumption will cause reef deoxygenation. Here we tested this hypothesis by analyzing reef microbial and primary producer oxygen metabolisms. Metagenomic data and in vitro incubations of bacteria with primary pro...
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