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Eligibility for alirocumab or evolocumab treatment in 1090 hypercholesterolemic patients referred to a regional cholesterol treatment center with LDL cholesterol ≥70 mg/dL despite maximal-tolerated LDL-cholesterol-lowering therapy
作者：Vybhav Jetty , Charles Glueck , Kevin Lee ...
来源：[J].Vascular Health and Risk Management, 2017, Vol.2017 (default), pp.247-253Dove
摘要：Background - PCSK9 inhibitors, Praluent (alirocumab [ALI]) and Repatha (evolocumab [EVO]), have been approved as adjuncts to the standard-of-care maximally tolerated dose (MTD) of low density lipoprotein cholesterol (LDLC) lowering therapy (LLT), statin therapy, in heterozyg...
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    Role of TIM-4 in exosome-dependent entry of HIV-1 into human immune cells
    作者：Brian Sims , Anitra Farrow , Sparkle Williams ...
    来源：[J].International Journal of Nanomedicine(IF 3.463), 2017, Vol.2017 (default), pp.4823-4833Dove
    摘要：Exosomes, 30-200-nm nanostructures secreted from donor cells and internalized by recipient cells, can play an important role in the cellular entry of some viruses. These microvesicles are actively secreted into various body fluids, including blood, urine, saliva, cerebrospinal fl...
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      Pharmacological treatment of osteoporosis in the oldest old
      作者：Anne-Marie Vandenbroucke , Frank Luyten , Johan Flamaing ...
      来源：[J].Clinical Interventions in Aging, 2017, Vol.2017 (default), pp.1065-1077Dove
      摘要：The incidence of osteoporotic fractures increases with age. Consequently, the global prevalence of osteoporotic fractures will rise with the ageing of the population. In old age, osteoporosis is associated with a substantial burden in terms of morbidity and mortality. Nevert...
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        Attention–memory training yields behavioral and academic improvements in children diagnosed with attention-deficit hyperactivity disorder comorbid with a learning disorder
        作者：Antonio Carlos Farias , Mara L. Cordeiro , Erico PG Felden ...
        来源：[J].Neuropsychiatric Disease and Treatment, 2017, Vol.2017 (default), pp.1761-1769Dove
        摘要：Background: Recent studies have suggested that children with attention-deficit hyperactivity/ disorder (ADHD) may benefit from computerized cognitive training. Therapy implementation is especially complicated when ADHD is associated with learning disorders (LDs). The present stud...
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          Diagnostic reliability of pediatric appendicitis score, ultrasound and low-dose computed tomography scan in children with suspected acute appendicitis
          作者：Ashraf Sayed , Nancy Zeidan , Dalia Fahmy ...
          来源：[J].Therapeutics and Clinical Risk Management, 2017, Vol.2017 (default), pp.847-854Dove
          摘要：Background: Diagnosis of appendicitis in children is clinically challenging, computed tomography (CT) is the gold standard for diagnosis; there is a concern about radiation exposure early in life. The aim is to evaluate the diagnostic reliability of low dose CT, pediatric ap...
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            A case of iatrogenic pneumothorax in which chest tube placement could be avoided by intraoperative evaluation with transthoracic ultrasonography
            作者：Izumi Sato , Hirotsugu Kanda , Megumi Kanao-Kanda ...
            来源：[J].Therapeutics and Clinical Risk Management, 2017, Vol.2017 (default), pp.843-845Dove
            摘要：We report a case of iatrogenic pneumothorax in which chest tube placement was avoided by continuous intraoperative evaluation with transthoracic ultrasound. A 53-year-old man was undergoing a subsegmentectomy. While attempting to place a central venous catheter in the right inter...
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              Brain regions associated with anosognosia for memory disturbance in Alzheimer’s disease: a magnetic resonance imaging study
              作者：Hiroshi Fujimoto , Teruyuki Matsuoka , Yuka Kato ...
              来源：[J].Neuropsychiatric Disease and Treatment, 2017, Vol.2017 (default), pp.1753-1759Dove
              摘要：Background and Objective: Patients with Alzheimer’s disease (AD) are frequently unaware of their cognitive symptoms and medical diagnosis. The term "anosognosia" is used to indicate a general lack of awareness of one's disease or disorder. The neural substrate underlying ano...
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                Apatinib-loaded nanoparticles suppress vascular endothelial growth factor-induced angiogenesis and experimental corneal neovascularization
                作者：Jung Eun Lee , Koung Li Kim , Danbi Kim ...
                来源：[J].International Journal of Nanomedicine(IF 3.463), 2017, Vol.2017 (default), pp.4813-4822Dove
                摘要：Pathological angiogenesis is one of the major symptoms of severe ocular diseases, including corneal neovascularization. The blockade of vascular endothelial growth factor (VEGF) action has been recognized as an efficient strategy for treating corneal neovascularization. In this s...
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                  Antithrombotic prophylaxis of atrial fibrillation in an Italian real-world setting: a retrospective study
                  作者：Giuliano Ermini , Valentina Perrone , Chiara Veronesi ...
                  来源：[J].Vascular Health and Risk Management, 2017, Vol.2017 (default), pp.239-246Dove
                  摘要：OBJECTIVES: The aim of this study was to assess the prevalence of diagnosed atrial fibrillation (AF), the drug use in patients with AF in terms of antithrombotic (AT) strategies used, the compliance with treatment and to describe the characteristics of patients affected by A...
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                    Chitosan-coated diacerein nanosuspensions as a platform for enhancing bioavailability and lowering side effects: preparation, characterization, and ex vivo/in vivo evaluation
                    作者：Ahmed Allam , Sherif Hamdallah , Ossama Abdallah
                    来源：[J].International Journal of Nanomedicine(IF 3.463), 2017, Vol.2017 (default), pp.4733-4745Dove
                    摘要：Nano drug delivery systems have been widely reviewed for their use in several drug formulations to improve bioavailability, sustain effect, and decrease side effects of many candidate drugs. The objective of this investigation was to evaluate the potential of chitosan coated...
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