De Gruyter期刊
期刊
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作者:Georgeta Serban
来源:[J].Acta Pharmaceutica, 2020, Vol.70 (3), pp.259-290De Gruyter
摘要:Abstract Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan parasites with ove...
作者:Katarzyna Lipska , Anna Gumieniczek , Agata A. Filip
来源:[J].Acta Pharmaceutica, 2020, Vol.70 (3), pp.291-301De Gruyter
摘要:Abstract Results from numerous pre-clinical studies suggest that a well known anticonvulsant drug valproic acid (VPA) and other short-chain fatty acids (SCFAs) cause significant inhibition of cancer cell proliferation by modulating multiple signaling pathways. First of all, they ...
作者:Fadel Wedian , Anas Lataifeh , Makaseb S. Mohammed
来源:[J].Acta Pharmaceutica, 2020, Vol.70 (3), pp.373-385De Gruyter
摘要:Abstract Green and sensitive spectrofluorometric methods have been developed and validated for the determination of timolol maleate (TML)/hydrochlorothiazide (HCT) and amiloride hydrochloride (AMH)/hydrochlorothiazide in tablets. The proposed spectrofluorometric procedures w...
作者:Aref Zayed , Wahby M. Babaresh , Ruba S. Darweesh ...
来源:[J].Acta Pharmaceutica, 2020, Vol.70 (3), pp.343-357De Gruyter
摘要:Abstract In this study, high-performance liquid chromatography with fluorescence detection (HPLC-FLD) has been used for the first time, for direct determination of warfarin and its major metabolite, 7-hydroxywarfarin, in rat plasma. The simple and sensitive method was develo...
作者:Naizhi Wang , Tao Feng , Xiaona Liu ...
来源:[J].Acta Pharmaceutica, 2020, Vol.70 (3), pp.399-409De Gruyter
摘要:Abstract Curcumin has been proved to inhibit cell proliferation and induce cell apoptosis in non-small cell lung cancer (NSCLC). However, little is known about antimetastatic effects and molecular mechanisms of curcumin in NSCLC. In this study, we investigated the involvemen...
作者:Blaž Grilc , Jurij Zdovc , Odon Planinšek
来源:[J].Acta Pharmaceutica, 2020, Vol.70 (3), pp.359-371De Gruyter
摘要:Abstract Films for buccal application are a slowly emerging new platform for drug delivery. There remains a lack of analytical techniques for the determination of in vitro active pharmaceutical ingredient release. The aim here was to develop an alternative method to the commonly ...
作者:León Jesús Germán-Ponciano , Abraham Puga-Olguín , María De Jesús Rovirosa-Hernández ...
来源:[J].Acta Pharmaceutica, 2020, Vol.70 (3), pp.387-397De Gruyter
摘要:Abstract The aim of this study was to compare the effects of acute (a single injection) and chronic (21 consecutive days) treatments with chrysin 2, 4, and 8 μmol kg−1 on anxiety-like behavior and Fos immunoreactivity in the lateral septum nucleus (LSN), a structu...
作者:Diana Tzankova , Stanislava Vladimirova , Denitsa Aluani ...
来源:[J].Acta Pharmaceutica, 2020, Vol.70 (3), pp.303-324De Gruyter
摘要:Abstract Six new N -pyrrolylhydrazide hydrazones were synthesized under micro synthesis conditions, assuring about 59–93 % yield, low harmful emissions and reagent economy. The structures of the new compounds were elucidated by melting points, TLC characteristics, IR, 1...
作者:Rabab M. Soliman , Randa A. Abdel Salam , Basma G. Eid ...
来源:[J].Acta Pharmaceutica, 2020, Vol.70 (3), pp.325-342De Gruyter
摘要:Abstract The aim of this study was to investigate the stability of three major antioxidants of Nigella sativa : thymoquinone (TQ), carvacrol (CR) and thymol (THY), under different stress conditions using HPLC and LC-MS/MS. Forced degradation for each compound was performed under ...
作者:Fugen Gu , Huimin Fan , Zhixin Cong ...
来源:[J].Acta Pharmaceutica, 2020, Vol.70 (3), pp.411-422De Gruyter
摘要:Abstract Donepezil hydrochloride thermosensitive in situ gel for nasal delivery was prepared by using Poloxamer 407 and Poloxamer 188 as thermoreversible polymers, hydroxypropyl- β -cyclodextrin and ethylparaben as permeation enhancer and preservative, respectively. The gela...

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