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作者:Frédéric Landmann , Pascale Cossart , Craig R. Roy ...
来源:[J].Microbiology Spectrum, 2019, Vol.7 (2)ASM Press
摘要:The Wolbachia endosymbionts encompass a large group of intracellular bacteria of biomedical and veterinary relevance, closely related to Anaplasma, Ehrlichia, and Rickettsia. This genus of Gram-negative members of the Alphaproteobacteria does not infect vertebrates but is in...
作者:Pamela Schnupf , Philippe J. Sansonetti , Pascale Cossart ...
来源:[J].Microbiology Spectrum, 2019, Vol.7 (2)ASM Press
摘要:Shigella is a genus of Gram-negative enteropathogens that have long been, and continue to be, an important public health concern worldwide. Over the past several decades, Shigella spp. have also served as model pathogens in the study of bacterial pathogenesis, and Shigella flexne...
作者:Gio J. Baracco , Vincent A. Fischetti , Richard P. Novick ...
来源:[J].Microbiology Spectrum, 2019, Vol.7 (2)ASM Press
摘要:Streptococci carrying serogroup C and G antigens, and in particular, Streptococcus dysgalactiae subsp. equisimilis (SDSE), are emerging human pathogens that are increasingly isolated from patients with a myriad of infections that range from mundane to life-threatening. SDSE is mi...
作者:James C. Paton , Claudia Trappetti , Vincent A. Fischetti ...
来源:[J].Microbiology Spectrum, 2019, Vol.7 (2)ASM Press
摘要:The polysaccharide capsule of Streptococcus pneumoniae is the dominant surface structure of the organism and plays a critical role in virulence, principally by interfering with host opsonophagocytic clearance mechanisms. The capsule is the target of current pneumococcal vaccines,...
作者:Michael Connor , Laurence Arbibe , Mélanie Hamon ...
来源:[J].Microbiology Spectrum, 2019, Vol.7 (2)ASM Press
摘要:Successful bacterial colonizers and pathogens have evolved with their hosts and have acquired mechanisms to customize essential processes that benefit their lifestyle. In large part, bacterial survival hinges on shaping the transcriptional signature of the host, a process regulat...
作者:Annika Hausmann , Wolf-Dietrich Hardt , Pascale Cossart ...
来源:[J].Microbiology Spectrum, 2019, Vol.7 (2)ASM Press
摘要:Bacterial infection results in a dynamic interplay between the pathogen and its host. The underlying interactions are multilayered, and the cellular responses are modulated by the local environment. The intestine is a particularly interesting tissue regarding host-pathogen intera...
作者:Virginie Stévenin , Jost Enninga , Pascale Cossart ...
来源:[J].Microbiology Spectrum, 2019, Vol.7 (2)ASM Press
摘要:The spatial dimensions of host cells and bacterial microbes are perfectly suited to being studied by microscopy techniques. Therefore, cellular imaging has been instrumental in uncovering many paradigms of the intracellular lifestyle of microbes. Initially, microscopy was used as...
作者:Dirk Bumann , Pascale Cossart , Craig R. Roy ...
来源:[J].Microbiology Spectrum, 2019, Vol.7 (2)ASM Press
摘要:Systemic Salmonella enterica infections are a major cause of mortality worldwide and are becoming increasingly untreatable. Recent single-cell data from a mouse model of typhoid fever show that the host immune system actually eradicates many Salmonella cells, while other Salmonel...
作者:Yan Li , James P. Di Santo , Pascale Cossart ...
来源:[J].Microbiology Spectrum, 2019, Vol.7 (2)ASM Press
摘要:Human immune system (HIS) mice are created by transplanting human immune cells or their progenitor cells into highly immunodeficient recipient mouse hosts, thereby “humanizing” their immune systems. Over past decades, the field of HIS mice has evolved rapidly, as modificatio...
作者:Amy Yeung , Christine Hale , Simon Clare ...
来源:[J].Microbiology Spectrum, 2019, Vol.7 (2)ASM Press
摘要:The rapid development of genomics and other “-omics” approaches has significantly impacted how we have investigated host-pathogen interactions since the turn of the millennium. Technologies such as next-generation sequencing, stem cell biology, and high-throughput proteomics...

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