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作者:Sarfaraz A. Hasni , Leyla Y. Teos , Ilias Alevizos
来源:[B].Clinical Immunology2019Elsevier
摘要:Sjögren syndrome (SS) is a chronic systemic autoimmune disease characterized by lachrymal and salivary gland dysfunction. It was named after the Swedish ophthalmologist Henrik Sjögren after he reported 19 cases of keratoconjunctivitis in 1933.The hallmark feature of SS is de...
作者:Giovanna Liuzzo , Daniela Pedicino , Davide Flego ...
来源:[B].Clinical Immunology2019Elsevier
摘要:The spectrum of the clinical syndromes caused by coronary atherosclerosis ranges from asymptomatic disease and stable angina (SA) to acute coronary syndromes (ACS). Although the early outcome of ACS has considerably improved in the past decade, cardiovascular diseases still repre...
作者:Peter J. Mannon
来源:[B].Clinical Immunology2019Elsevier
摘要:The gastrointestinal (GI) tract contains the largest mass of immune cells of any organ in the body. To manage the continuous exposure to environmental and dietary antigens and to commensal microbes, pathogens, and their metabolic products, the gut uses a number of strategies that...
作者:Catherine Lemière , James G. Martin
来源:[B].Clinical Immunology2019Elsevier
摘要:Occupational asthma (OA) is a unique phenotype of asthma. Depending on the type of sensitizers to which the subjects are exposed, different pathophysiological mechanisms lead to the development of OA. This chapter reviews our current understanding of the mechanisms of occupationa...
作者:Dimitrios S. Monos , Robert J. Winchester
来源:[B].Clinical Immunology2019Elsevier
摘要:The major histocompatibility complex (MHC) is an approximately four-megabase segment of DNA on the short arm of chromosome 6. It is a dense genomic region that includes many genes involved in the immune response, whether innate or adaptive. It has been determined to be the s...
作者:Arnold I. Levinson
来源:[B].Clinical Immunology2019Elsevier
摘要:Myasthenia gravis (MG) is an autoimmune disease characterized by weakness of striated muscles. The weakness is caused by impaired neuromuscular transmission resulting from a reduction in the number of receptors for the neuromuscular type of nicotinic acetylcholine receptor (...
作者:Todd N. Eagar , Stephen D. Miller
来源:[B].Clinical Immunology2019Elsevier
摘要:CD4 T cells are critical components of the immune system and key regulators of the inflammatory processes required to limit infection. Decades of research has led to the discovery of multiple CD4 T-cell subsets (T-helper cell 1 [Th1], Th2, Th17, Th9, Th22, Tfh) that promote the f...
作者:Prosper N. Boyaka , Kohtaro Fujihashi
来源:[B].Clinical Immunology2019Elsevier
摘要:The inner body or systemic compartment of mammals is maintained sterile and free of microbes, foreign antigens, and altered or dead cells through the action of mucosal epithelia as well as that of immune cells present in the bloodstream. Mammals have large surfaces that are in co...
作者:W. Winn Chatham
来源:[B].Clinical Immunology2019Elsevier
摘要:During recent decades, the elucidation of specific inflammatory mediators and identification of lymphocyte lineages that contribute to the pathology underlying chronic inflammatory disorders have identified immunological targets amenable to modification by use of recombinant...

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