Bentham期刊
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作者:Eman Bobtaina , Enise Ece Gurdal , Irem Durmaz ...
来源:[J].Letters in Drug Design & Discovery(IF 0.845), 2019, Vol.16 (1), pp.45-51Bentham
摘要:Background: In this study, nine novel compounds, bearing N-[2-(4-substitutedpiperazine-1-yl)acetyl]-N’-[bis-(4-fluorophenyl)methyl]piperazine structures were synthesized.Methods: Their cytotoxic properties were evaluated in vitro by NCI-60 Sulforhodamine B(SRB) assay against...
作者:Tiago Matos , Leif Bülow
来源:[J].Current Protein & Peptide Science(IF 2.326), 2019, Vol.20 (1), pp.49-55Bentham
摘要:The needs for purified nucleic acids for preparative and analytical applications have increasedconstantly, demanding for the development of new and more efficient methods for their recovery andisolation. DNA molecules harbour some intrinsic chemical properties that render them su...
作者:Xuemei M. He , Carsten Voß , Jidong Li
来源:[J].Current Protein & Peptide Science(IF 2.326), 2019, Vol.20 (1), pp.65-74Bentham
摘要:Background: Mixed-mode chromatography is becoming an important tool for downstreamprocess purification, as it provides the selectivity and robustness unmatched by conventional singlemodechromatographic methods. The joint action of multiple functionalities present on the ligands o...
作者:Vivek Halan , Sunit Maity , Rahul Bhambure ...
来源:[J].Current Protein & Peptide Science(IF 2.326), 2019, Vol.20 (1), pp.4-13Bentham
摘要:Process chromatography forms the core of purification of biotherapeutics. The unparalleledselectivity that it offers over other alternatives combined with the considerable robustness and scalabilitymake it the unit operation of choice in downstream processing. It is typical to ha...
作者:Atsushi Hirano , Kentaro Shiraki , Tomoshi Kameda
来源:[J].Current Protein & Peptide Science(IF 2.326), 2019, Vol.20 (1), pp.40-48Bentham
摘要:Multimodal or mixed-mode chromatography can be used to separate various proteins, includingantibodies. The separation quality and efficiency have been improved by the addition of solutes, especiallyarginine. This review summarizes the mechanism underlying the effects of arginine ...
作者:Aniket P. Sarkate , Kshipra S. Karnik , Pravin S. Wakte ...
来源:[J].Letters in Drug Design & Discovery(IF 0.845), 2019, Vol.16 (1), pp.3-10Bentham
摘要:Background: A novel copper-catalyzed synthesis of substituted-1,2,3-triazole derivativeshas been developed and performed by Huisgen 1,3-dipolar cycloaddition reaction of azides withalkynes. The reaction is one-pot multicomponent.Objective: We state the advancement and execution o...
作者:George Perry
来源:[J].Letters in Drug Design & Discovery(IF 0.845), 2019, Vol.16 (1), pp.2-2Bentham
作者:Pawan Gupta , Aleksandrs Gutcaits
来源:[J].Letters in Drug Design & Discovery(IF 0.845), 2019, Vol.16 (1), pp.11-20Bentham
摘要:Background: B-cell Lymphoma Extra Large (Bcl-XL) belongs to B-cell Lymphoma two(Bcl-2) family. Due to its over-expression and anti-apoptotic role in many cancers, it has been provento be a more biologically relevant therapeutic target in anti-cancer therapy. In this study, a Quan...
作者:Ran Wei , Libin Guo , Qingshui Wang ...
来源:[J].Current Protein & Peptide Science(IF 2.326), 2019, Vol.20 (1), pp.82-91Bentham
摘要:Programmed death ligand 1 (PD-L1) is a cell membrane protein that binds to programmedcell death protein 1 (PD-1) on the effector T cells and transduces immunosuppressive signals. It is nowclear that the expression of the PD-L1 protein on the tumor cell surface is critical for tum...
作者:Zehra Tuğçe Gür , Fatma Sezer Şenol , Suhaib Shekfeh ...
来源:[J].Letters in Drug Design & Discovery(IF 0.845), 2019, Vol.16 (1), pp.36-44Bentham
摘要:Background: A series of novel cinnamic acid piperazine amide derivatives has beendesigned and synthesized, and their biological activities were also evaluated as potential tyrosinaseinhibitors.Methods: Compounds 9, 11 and 17 showed the most potent biological activity (IC50 =...

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