Bentham期刊
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作者:Laura Martelli , Laurent Peyrin-Biroulet
来源:[J].Current Medicinal Chemistry(IF 4.07), 2019, Vol.26 (2), pp.270-279Bentham
摘要:Background: Anti-tumor necrosis factor (anti-TNF) monoclonal antibodies have revolutionized the treatment of inflammatory bowel diseases (IBD). However, because of their complexity, their production is expensive contributing to their high price. As the patent protection of t...
作者:Kyriaki Hatziagapiou , Eleni Kakouri , George I. Lambrou ...
来源:[J].Current Neuropharmacology(IF 2.031), 2019, Vol.17 (4), pp.377-402Bentham
摘要:Background: Reactive oxygen species and reactive nitrogen species, which are collectively called reactive oxygen-nitrogen species, are the inevitable by-products of cellular metabolic redox reactions, such as oxidative phosphorylation in the mitochondrial respiratory chain, ...
作者:Vinita Chauhan , Ritika Chauhan , Priyanka Sonkar ...
来源:[J].Protein & Peptide Letters(IF 1.994), 2019, Vol.26 (3), pp.227-234Bentham
摘要:Background: Shiga toxins comprise a family of related proteins produced by bacteria Shigella dysenteriae and some strains of Escherichia coli that cause severe clinical manifestations. Severe Shiga toxin intoxication results in Haemolytic-Uremic Syndrome (HUS), up to 50% of HUS p...
作者:Elham Rajaei , Habib Haybar , Karim Mowla ...
来源:[J].Current Rheumatology Reviews, 2019, Vol.15 (2), pp.116-122Bentham
摘要:Background: Rheumatoid arthritis is a widespread autoimmune disease and inflammation and bone destruction are two main issues in rheumatoid arthritis. Objective: To discussing metformin effects on rheumatoid arthritis complications. Methods: We conducted a narrative literatu...
作者:Mahboubeh Zarei , Mohammad Reza Rahbar , Mohammad Hossein Morowvat ...
来源:[J].Recent Patents on Biotechnology, 2019, Vol.13 (2), pp.124-136Bentham
摘要:Background: Arginine deiminase (ADI), an arginine catabolizing enzyme, is considered as an anti-tumor agent for the treatment of arginine auxotrophic cancers. However, some obstacles limit its clinical applications. Objective: This review will summarize the clinical applications ...
作者:Andrew Kwan , Patricia Katz , Zahi Touma
来源:[J].Current Rheumatology Reviews, 2019, Vol.15 (2), pp.90-98Bentham
摘要:Background: Depression and anxiety are common neuropsychiatric complaints in patients with Systemic Lupus Erythematosus (SLE). While numerous studies have been performed to investigate the prevalence, impact, and associated factors of depression and anxiety, current literature pr...
作者:Wioletta Rozpędek , Dariusz Pytel , Tomasz Popławski ...
来源:[J].Current Alzheimer Research(IF 3.676), 2019, Vol.16 (3), pp.209-218Bentham
摘要:Objectives: There is a body of evidence that neurodegenerative disease entities are directly correlated with the perturbations on the molecular level. Hence, the ER stress-mediated Unfolded Protein Response (UPR) is activated resulting in PERK-dependent phosphorylation of th...
作者:Alexey V. Baldin , Andrey A. ZamyatninJr , Alexandr V. Bazhin ...
来源:[J].Current Medicinal Chemistry(IF 4.07), 2019, Vol.26 (3), pp.427-445Bentham
摘要:Current advances in cancer treatment are based on the recent discoveries of molecular mechanisms of tumour maintenance. It was shown that heat shock proteins (HSPs) play a crucial role in the development of immune response against tumours. Thus, HSPs represent multifunctional age...
作者:Casey Burton , Yinfa Ma
来源:[J].Current Medicinal Chemistry(IF 4.07), 2019, Vol.26 (1), pp.5-28Bentham
摘要:Background: The development of effective screening methods for early cancer detection is one of the foremost challenges facing modern cancer research. Urinary metabolomics has recently emerged as a potentially transformative approach to cancer biomarker discovery owing to its non...

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