Annual Reviews期刊
期刊
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作者:Dario Neri , Richard A. Lerner
来源:[J].Annual Review of Biochemistry(IF 27.681), 2018, Vol.87, pp.479-502Annual Reviews
摘要:The discovery of organic ligands that bind specifically to proteins is a central problem in chemistry, biology, and the biomedical sciences. The encoding of individual organic molecules with distinctive DNA tags, serving as amplifiable identification bar codes, allows the constru...
作者:Samar A. Mahmoud , Peter Chien
来源:[J].Annual Review of Biochemistry(IF 27.681), 2018, Vol.87, pp.677-696Annual Reviews
摘要:Regulated proteolysis is a vital process that affects all living things. Bacteria use energy-dependent AAA+ proteases to power degradation of misfolded and native regulatory proteins. Given that proteolysis is an irreversible event, specificity and selectivity in degrading substr...
作者:Jennifer Bridwell-Rabb , Tsehai A.J. Grell , Catherine L. Drennan
来源:[J].Annual Review of Biochemistry(IF 27.681), 2018, Vol.87, pp.555-584Annual Reviews
摘要:S-adenosylmethionine (AdoMet) has been referred to as both “a poor man's adenosylcobalamin (AdoCbl)” and “a rich man's AdoCbl,” but today, with the ever-increasing number of functions attributed to each cofactor, both appear equally rich and surprising. The recent chara...
作者:Tilman Schneider-Poetsch , Minoru Yoshida
来源:[J].Annual Review of Biochemistry(IF 27.681), 2018, Vol.87, pp.391-420Annual Reviews
摘要:The central dogma of molecular biology, that DNA is transcribed into RNA and RNA translated into protein, was coined in the early days of modern biology. Back in the 1950s and 1960s, bacterial genetics first opened the way toward understanding life as the genetically encoded inte...
作者:Md. Saiful Islam , Thomas M. Leissing , Rasheduzzaman Chowdhury ...
来源:[J].Annual Review of Biochemistry(IF 27.681), 2018, Vol.87, pp.585-620Annual Reviews
摘要:2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations proceeding via hydroxylation; in plants and microbes, they catalyze a wider range including ring formations...
作者:Mary C. Andorfer , Jared C. Lewis
来源:[J].Annual Review of Biochemistry(IF 27.681), 2018, Vol.87, pp.159-185Annual Reviews
摘要:Flavin-dependent halogenases (FDHs) catalyze the halogenation of organic substrates by coordinating reactions of reduced flavin, molecular oxygen, and chloride. Targeted and random mutagenesis of these enzymes have been used to both understand and alter their reactivity. These st...
作者:Enrico Cappellini , Ana Prohaska , Fernando Racimo ...
来源:[J].Annual Review of Biochemistry(IF 27.681), 2018, Vol.87, pp.1029-1060Annual Reviews
摘要:Over the past three decades, studies of ancient biomolecules—particularly ancient DNA, proteins, and lipids—have revolutionized our understanding of evolutionary history. Though initially fraught with many challenges, today the field stands on firm foundations. Researchers n...
作者:Lianet Noda-Garcia , Wolfram Liebermeister , Dan S. Tawfik
来源:[J].Annual Review of Biochemistry(IF 27.681), 2018, Vol.87, pp.187-216Annual Reviews
摘要:How individual enzymes evolved is relatively well understood. However, individual enzymes rarely confer a physiological advantage on their own. Judging by its current state, the emergence of metabolism seemingly demanded the simultaneous emergence of many enzymes. Indeed, ho...
作者:William I. Weis , Brian K. Kobilka
来源:[J].Annual Review of Biochemistry(IF 27.681), 2018, Vol.87, pp.897-919Annual Reviews
摘要:G protein–coupled receptors (GPCRs) mediate the majority of cellular responses to external stimuli. Upon activation by a ligand, the receptor binds to a partner heterotrimeric G protein and promotes exchange of GTP for GDP, leading to dissociation of the G protein into α and...
作者:Hans Clevers , Fiona M. Watt
来源:[J].Annual Review of Biochemistry(IF 27.681), 2018, Vol.87, pp.1015-1027Annual Reviews
摘要:Central to the classical hematopoietic stem cell (HSC) paradigm is the concept that the maintenance of blood cell numbers is exclusively executed by a discrete physical entity: the transplantable HSC. The HSC paradigm has served as a stereotypic template in stem cell biology, yet...

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