全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Yan Li , Xiaolin Ma , Yanpeng Wang ...
来源:[J].Biomedicine & Pharmacotherapy(IF 2.068), 2017, Vol.93, pp.435-443Elsevier
摘要:Abstract(#br)microRNA-489 (miR-489), a newly identified tumor-related miRNA, functions as an oncogene or tumor suppressor via regulating growth and metastasis of human cancers. But, the clinical significance, biological function and underlying mechanisms of miR-489 in glioma rema...
作者:Dawei Xu , Ruihua Liu , Lei Meng ...
来源:[J].Biomedicine & Pharmacotherapy(IF 2.068), 2018, Vol.100, pp.20-28Elsevier
摘要:... Further, we identified miR-489 as a direct target of ENST01108 and ENST01108 negatively regulate miR-489 by act as a sponge. SIK1 is verified as the direct target of miR-489 and it is negatively regulated by miR-489. ENST01108 also positively regulate SIKI and it promotes SIK...
作者:S. Gao , H. Liu , S. Hou ...
来源:[J].Clinical and Translational Oncology(IF 1.276), 2018, Vol.20 (6), pp.703-712Springer
摘要:Abstract(#br) Purpose(#br)The expression of miR-489 is linked to tumor development and progression; nevertheless, its role in tumor growth and invasion of colorectal cancer (CRC) and the underlying mechanism has not been clarified.(#br) Experimental design(#br)We used quantit...
作者:Zongtao Xie , Liming Cai , Runsheng Li ...
来源:[J].Tumor Biology(IF 2.518), 2015, Vol.36 (8), pp.6497-6505Springer
摘要:... However, the potential role of miR-489 in the development of Non-Small Cell Lung Cancer (NSCLC) is not demonstrated. In present study, miR-489 was down-regulated both in tumor tissues and cells. Inhibition of miR-489 promoted cells invasion by using an invasion assay. Further...
作者:Kun Wang , Fang Liu , Lu-Yu Zhou ...
来源:[J].Circulation Research(IF 11.861), 2014, Vol.114 (9), pp.1377-1388Wolters Kluwer
摘要:... OBJECTIVE:: We identified miR-489 and lncRNAs (cardiac hypertrophy related factor, CHRF) from hypertrophic cardiomyocytes. Here, we tested the hypothesis that miR-489 and CHRF can participate in the regulation of cardiac hypertrophy in vivo and in vitro. METHODS AND RESULTS::...
作者:Huijuan Wu , Zhenghua Xiao , Hua Zhang ...
来源:[J].Anti-Cancer Drugs(IF 2.232), 2014, Vol.25 (7), pp.799-809Wolters Kluwer
摘要:... In the current study, we show that miR-489 is downregulated in cisplatin (CDDP)-resistant ovarian cancer cells, SKOV3/CDDP and OVCAR3/CDDP cells. MiR-489 overexpression results in an inhibition of SKOV3 and OVCAR3 cell survival and cell growth after CDDP treatment and an i...
作者:Wu Qiuyun , Han Lei , Yan Weiwen ...
来源:[J].Scientific reports(IF 2.927), 2016, Vol.6, pp.30921PubMed
摘要:... Our previous microRNA (miRNA, miR) microarray data have indicated decreased expression levels of miR-489 in lung tissues of silica-induced pulmonary fibrosis. Here, we further explored the role of miR-489 in a mouse model of silicosis. Interestingly, miR-489 levels were re...
作者:Yixiong Lin , Jianjun Liu , Yuqi Huang ...
来源:[J].Translational Oncology(IF 3.393), 2017, Vol.10 (2), pp.211-220Elsevier
摘要:... miR-489 was found to play either oncogenic or tumor suppressive roles in human cancers. Recent study reported that the levels of miR-489 in late recurrent HCC patients were evidently higher than that in early recurrent cases, suggesting that miR-489 may function as a tumor su...
作者:Patel Yogin , Shah Nirav , Lee Ji Shin ...
来源:[J].Oncotarget(IF 6.636), 2016, Vol.7 (14), pp.18295-308PubMed
摘要:... Our molecular study demonstrated that miR-489 was specifically downregulated by the HER2-downstream signaling, especially through the MAPK pathway. Restoration or overexpression of miR-489 in HER2-positive breast cancer cells significantly inhibited cell growth in vitro and d...

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