全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Jarosław Paluszczak , Dorota Wiśniewska , Magdalena Kostrzewska-Poczekaj ...
来源:[J].Clinical Oral Investigations(IF 2.2), 2017, Vol.21 (5), pp.1777-1788Springer
摘要:... This study aimed to assess the frequency of methylation of negative regulators of Wnt signaling: CXXC4 , DACT2 , HDPR1 , and FBXW11 and Shh signaling: HHIP , PTCH1 , SUFU , ZIC1 , and ZIC4 and correlate it with clinicopathological features in this group of patients.
作者:Masato Ohtsuka , Natsuko Kikuchi , Kenjiro Ozato ...
来源:[J].Genomics(IF 3.01), 2004, Vol.83 (6), pp.1063-1071Elsevier
摘要:... Sequence comparisons of developmental genes zic1 and zic4 , identified within this region, revealed that zic1 , but not zic4 , is highly conserved among vertebrates. The 5′ coding region of zic4 is, however, extremely homologous among fishes with little synonymous subs...
作者:Takahiko J. Fujimi , Katsuhiko Mikoshiba , Jun Aruga
来源:[J].Developmental Dynamics(IF 2.59), 2006, Vol.235 (12), pp.3379-3386Wiley
摘要:Abstract(#br)We compared the expression and function of Xenopus Zic4 with those of the other four Xenopus laevis Zic family members ( Zic1 , Zic2 , Zic3 , and Zic5 ). Zic4 expression was detected mainly in the neural plate border, dorsal neural tube, and somites, and was simi...
作者:Yuuta Moriyama , Toru Kawanishi , Ryohei Nakamura ...
来源:[J].Current Biology(IF 9.494), 2012, Vol.22 (7), pp.601-607Elsevier
摘要:... We first demonstrate that a large transposon, inserted into the enhancer region of the zic1 and zic4 genes ( zic1/zic4 ) in Da , is associated with the mesoderm-specific loss of their transcription. We then show that zic1/zic4 are strongly expressed in the dorsal part of...
作者:Gina E. Elsen , Louis Y. Choi , Kathleen J. Millen ...
来源:[J].Developmental Biology(IF 3.868), 2007, Vol.314 (2), pp.376-392Elsevier
摘要:... We have established that the formation of the hindbrain (4th) ventricle in zebrafish is dependent upon the pleiotropic functions of the genes implicated in human Dandy Walker Malformation, Zic1 and Zic4 . Using morpholino knockdown we show that zebrafish Zic1 and Zic4 are req...
作者:Jun Aruga , Arito Yozu , Yoshihide Hayashizaki ...
来源:[J].Gene(IF 2.196), 1996, Vol.172 (2), pp.291-294Elsevier
摘要:... We identified a novel gene, Zic4 , which belongs to the Zic gene family, through a genomic and cDNA cloning study. Zic4 is highly similar to Zicl, Zic2 and Zic3 , especially in its Zf motif. An analysis of the genomic organization of Zic4 showed that the gene shares a common ...
作者:Akira Ishiguro , Takashi Inoue , Katuhiko Mikoshiba ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2004, Vol.324 (1), pp.302-307Elsevier
摘要:... Here, we investigated the molecular properties of the Zic4 and Zic5 proteins. Zic4/Zic5 showed DNA-binding activity to the Gli-binding sequence, similar to Zic1/Zic2/Zic3 proteins. However, Zic4/Zic5 did not exhibit any significant transcriptional activation ability nor the...
作者:Takahiko J. Fujimi , Katsuhiko Mikoshiba , Jun Aruga
来源:[J].Developmental Dynamics(IF 2.59), 2006, Vol.235 (12), pp.spc1-spc1Wiley
摘要:Abstract(#br)Expression profiles of Xenopus laevis Zic genes during embryonic development. Whole‐mount in situ hybridization analyses with digoxigenin‐labeled probes were performed to determine the spatial expression patterns of each Zic gene during development. Photos in a ...
作者:Masato Ohtsuka , Natsuko Kikuchi , Hayato Yokoi ...
来源:[J].Mechanisms of Development(IF 2.383), 2004, Vol.121 (7), pp.873-882Elsevier
摘要:... In this study, we genetically specified the mutation to a 174-kb region harboring two zinc-finger type transcription factors, zic1 and zic4 , and compared the genomic structures of this region between wild-type and Da mutant fish. No mutation was found in the coding regions...
作者:McMahon Ariel , Merzdorf Christa
来源:[J].BMC Research Notes, 2010, Vol.3 (1), pp.167DOAJ
摘要:... Since little is known about zic gene expression in chick embryos, we have characterized the expression patterns of the zic1, zic2, zic3, and zic4 (zic1-4) genes during neurulation and somitogenesis. Findings We used in situ hybridization to analyze the expression patterns of ...

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