全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Dian Chen , Fanyuan Yu , Fanzi Wu ...
来源:[J].Archives of Oral Biology(IF 1.549), 2019, Vol.104, pp.123-132Elsevier
摘要:Abstract(#br)Objectives(#br)This study investigates the role of Wnt7b in mouse dentin formation.(#br)Design(#br)C57BL/6 mouse tooth germs at different developmental stages were collected to measure the expression of Wnt7b by immunohistochemical staining. The morphology of mandibl...
作者:Hongyang Lv , Jing Yang , Chenglin Wang ...
来源:[J].Archives of Oral Biology(IF 1.549), 2018, Vol.87, pp.54-61Elsevier
摘要:Abstract(#br)Objective(#br)The aim of this study is to investigate the role of the WNT7B protein in the migration and differentiation of human dental pulp cells (HDPCs).(#br)Design(#br)The effect of recombinant human WNT7B (rhWNT7B) on the proliferation and migration of HDPCs ...
作者:Yan‐Xia Chen , Chong Huang , Zhi‐Bing Duan ...
来源:[J].Kaohsiung Journal of Medical Sciences(IF 0.502), 2019, Vol.35 (7), pp.393-400DOAJ
摘要:... qRT‐PCR and western blot analysis were subjected to measure the expression of Klotho/FGF23 and correlated genes among Wnt7b/β‐catenin pathway. We found that the calcium content was obviously increased and Alizarin red staining was positive in calcification group expos...
作者:Cong Zhang , Xiuqin Yang , Chen Fu ...
来源:[J].Gene(IF 2.196), 2018, Vol.672, pp.172-179Elsevier
摘要:... Furthermore, miR-505 inactivated the Wnt/β-catenin signaling pathway by directly targeting and inhibiting WNT7B. In conclusion, our results demonstrated that the induction of miR-505 in combination with TMZ treatment could be a useful therapeutic strategy for suppressing...
作者:Junlong Li , Zhongping Chen , Yu Xiang ...
来源:[J].Biosensors and Bioelectronics(IF 5.437), 2016, Vol.86, pp.75-82Elsevier
摘要:Abstract(#br)Wnt7B gene plays an important role in the development and progression of breast cancer, gastric cancer, esophageal cancer and pancreatic cancer. While, the natural state of DNA is double stranded, which makes it difficult to be directly detected. Here, we develop an ...
作者:Liu , Wang , Zhou ...
来源:[J].Cell Cycle(IF 5.243), 2019, Vol.18 (23), pp.3325-3336Taylor & Francis
摘要:... Wnt7b, as a transforming member of the Wnt family, could activate mTORC1 through PI3K-AKT signaling and is upregulated in OS. In the present study, we found that miR-342-5p inhibits Wnt7b expression via direct binding to Wnt7b 3′-UTR. miR-342-5p overexpression remarkably...
作者:Jianquan Chen , Xiaolin Tu , Emel Esen ...
来源:[J].PLoS Genetics(IF 8.694), 2014, Vol.10 (1)DOAJ
摘要:... To investigate the osteogenic capacity of WNT7B and WNT5A, both normally expressed in the developing bone, we engineered mouse strains to express either protein in a Cre-dependent manner. Targeted induction of WNT7B, but not WNT5A, in the osteoblast lineage dramatically enhan...
作者:Joseph B. Lin , Abdoulaye Sene , Luke A. Wiley ...
来源:[J].Experimental Eye Research(IF 3.026), 2018Elsevier
摘要:... To evaluate in vivo relevance, we generated mice systemically deficient in Wnt7a and/or Wnt7b . Genetic deletion of both Wnt7a and Wnt7b decreased the severity of laser injury-induced choroidal neovascularization (CNV), while individual deletion of either Wnt7a or Wnt7b did ...
作者:Christopher Brynczka , B. Alex Merrick
来源:[J].Differentiation(IF 2.855), 2007, Vol.76 (7), pp.795-808Elsevier
摘要:... Wnt7b transcript and protein levels are increased following NGF treatment in a p53-dependent manner, as demonstrated by a reduction in wnt7b protein levels following stable shRNA-mediated silencing of p53. In addition, overexpressed human tp53 was capable of inducing marked wnt7b...
作者:Eve Kandyba , Krzysztof Kobielak
来源:[J].STEM CELLS(IF 7.701), 2014, Vol.32 (4), pp.886-901Wiley
摘要:... Here, we investigated the role of Wnt7b, which was also intrinsically upregulated in hfSCs during physiological and precocious anagen after BMP inhibition in vivo. We demonstrated Wnt7b to be a direct target of canonical BMP signaling in hfSCs and using Wnt7b conditional ge...

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