全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:You-jiang Min , Li-li-qiang Ding , Li-hong Cheng ...
来源:[J].Neural Regeneration Research(IF 0.144), 2017, Vol.12 (2), pp.276-282DOAJ
摘要:... The Rho/Rho-associated kinase (ROCK) signaling pathway regulates the actin cytoskeleton by controlling the adhesive and migratory behaviors of cells that could inhibit neurite regrowth after neural injury and consequently hinder the recovery from spinal cord injury. Therefore...
作者:Ya-Ting Cheng , Dong-Feng Yeih , Shu-Man Liang ...
来源:[J].International Journal of Cardiology(IF 5.509), 2015, Vol.201, pp.441-448Elsevier
摘要:Abstract(#br)Background(#br)Rho-associated kinase (ROCK) plays an important role in maintaining embryonic stem (ES) cell pluripotency. To determine whether ROCK is involved in ES cell differentiation into cardiac and hematopoietic lineages, we evaluated the effect of ROCK inhibi...
作者:Mun Sun Kim , Kwang-Seok Oh , Jeong Hyun Lee ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2013, Vol.438 (2), pp.318-323Elsevier
摘要:... Next, a Rho-associated kinase (ROCK) activity was measured because actin stress fiber formation and/or cellular hypertrophy are usually induced by the activation of ROCK. Rho-associated kinase 2 (ROCK2) studies using a time-resolved fluorescence resonance energy transfer ...
作者:Peicai Fu , Ronghua Tang , Zhiyuan Yu ...
来源:[J].Neuroscience Bulletin(IF 1.365), 2016, Vol.32 (1), pp.83-91Springer
摘要:... Rho-associated kinase (ROCK) has been identified as an important regulator of uptake, proliferation, secretion, and differentiation in a number of cell types. Although ROCK plays critical roles in the microglial secretion of inflammatory factors, migration, and morphology, it...
作者:Kanako Noritake , Toshihiko Aki , Takeshi Funakoshi ...
来源:[J].Toxicology in Vitro(IF 2.65), 2012, Vol.26 (6), pp.849-855Elsevier
摘要:... The addition of Y-27632, a specific inhibitor of Rho-associated kinase (ROCK), suppressed the membrane blebbing and mitochondrial apoptotic pathway. In comparison z-VAD-fmk, a pan-caspase inhibitor, did not inhibit membrane blebbing but did prevent cell death following exposu...
作者:Sahar Sweetat , Kobi Rosenblum , Raphael Lamprecht
来源:[J].Neurobiology of Learning and Memory(IF 3.327), 2012, Vol.97 (1), pp.1-6Elsevier
摘要:Abstract(#br)Rho-associated kinase (ROCK) is intimately involved in cortical neuronal morphogenesis. The present study explores the roles of ROCK in conditioned taste aversion (CTA) memory formation in gustatory cortex (GC) in adult rat. Microinjection of the ROCK inhibitor Y-27...
作者:Huang-Chung Chen , Jen-Ping Chang , Tzu-Hao Chang ...
来源:[J].BMC Cardiovascular Disorders(IF 1.457), 2015, Vol.15 (1)Springer
摘要:... However, the relationship between Rho-associated kinase (ROCK) and myolysis in the left atrial myocytes of MR patients remain unclear.(#br) Methods(#br)This study comprised 22 patients with severe MR [12 with atrial fibrillation (AF) and ten in sinus rhythm]. Left atrial app...
作者:Hal F. Yee , Andrew C. Melton , Binh N. Tran
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2001, Vol.280 (5), pp.1340-1345Elsevier
摘要:... Our aim was to test the hypothesis that the rhoA/rho-associated kinase signaling pathway is a principal mediator of contractile force generation in non-muscle cells. We measured myosin II regulatory light chain (MLC) phosphorylation and directly quantitated force generation b...
作者:Mutsuki Amano , Yuko Fukata , Kozo Kaibuchi
来源:[J].Experimental Cell Research(IF 3.557), 2000, Vol.261 (1), pp.44-51Elsevier
摘要:Abstract(#br)Remarkable progress has been made in understanding effector molecules of small GTPase Rho, especially Rho-associated kinase (Rho-kinase/ROK/ROCK), in the past 5 years. Rho-associated kinase appears to mediate a large proportion of the signals from Rho and regulate dy...
作者:Aleksandar I. Mihajlović , Alexander W. Bruce
来源:[J].Reproductive BioMedicine Online(IF 2.675), 2016, Vol.33 (3), pp.381-390Elsevier
摘要:... This study reports that the chemical inhibition of Rho-associated kinase (Rock) is associated with failure to form morphologically distinct blastocysts, indicative of compromised trophectoderm differentiation, and defects in the localization of both apical and basolateral pol...

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