全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Eun-A Jang , Ji-A Song , Ji Youn Shin ...
来源:[J].BMC Anesthesiology(IF 1.188), 2017, Vol.17 (1)Springer
摘要:Administration of arginine vasopressin (AVP) is associated with reducing jugular venous (SjvO2) and regional cerebral (rScO2) oxygen saturation under propofol-remifentanil (P/R) anaesthesia. We determined whether background anaesthetics modulate the effect o...
作者:Clarissa N. Amaya , Dianne C. Mitchell , Brad A. Bryan
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:The serine/threonine protein kinases ROCK1 and 2 are key RhoA-mediated regulators of cell shape and cytoskeletal dynamics. These proteins perform multiple functions in vascular endothelial cell physiology and are attractive targets for cancer therapy based on their roles as oncog...
作者:Nobuhiro Kushida , Osamu Yamaguchi , Yohei Kawashima ...
来源:[J].BMC Urology(IF 1.694), 2016, Vol.16 (1)Springer
摘要:... Since the activity of Rho kinase is known to be upregulated in the obstructed bladder, we investigate the roles of the RhoA/Rho kinase pathway in mechanical overloaded bladder smooth muscle cells.(#br) Methods(#br)Human bladder smooth muscle cells were stimulated on silicon c...
作者:E. Nazarshodeh , F. Shiri , Jahan B. Ghasemi
来源:[J].Journal of the Iranian Chemical Society(IF 1.467), 2015, Vol.12 (11), pp.1945-1959Springer
摘要:Abstract(#br)Among the most well-known members of the serine/threonine (Ser/Thr) protein kinase family are Rho kinases. They are potential targets to treat some diseases, such as cancer, cardiovascular diseases and multiple sclerosis, because of their key roles in the organi...
作者:Hannah Kenward , Jonathan Elliott , Terry Lee ...
来源:[J].BMC Veterinary Research(IF 1.861), 2017, Vol.13 (1)Springer
摘要:... The aims of this study were to determine the efficacy of three classes of antiemetic drugs in a novel low dose cisplatin model of nausea and vomiting and measure change in potential nausea biomarkers arginine vasopressin (AVP) and cortisol. A four period cross-over blinded st...
作者:Xiangbing Wu , Xiao-ming Xu
来源:[J].Neural Regeneration Research(IF 0.144), 2016, Vol.11 (1), pp.23-27DOAJ
摘要:... Among them, the RhoA/Rho kinase pathway plays a particular role in mediating spinal degeneration and regeneration. In this review, we will discuss the role and mechanism of RhoA/Rho kinase-mediated spinal cord pathogenesis, as well as the potential of targeting RhoA/Rho kinase...
作者:Helmut Schaschl , Susanne Huber , Katrin Schaefer ...
来源:[J].BMC Evolutionary Biology(IF 3.285), 2015, Vol.15 (1)Springer
摘要:Abstract(#br) Background(#br)The evolutionary highly conserved neurohypophyseal hormones oxytocin and arginine vasopressin play key roles in regulating social cognition and behaviours. The effects of these two peptides are meditated by their specific receptors, which are encod...
作者:Yang Ye , Xue Lv , Mei-hui Wang ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2015, Vol.129 (4), pp.205-209Elsevier
摘要:... The inhibitory effect on collagen I expression was reversed by geranylgeraniol, and mimicked by inhibitors of RhoA/Rho kinase pathway including C3 exoenzyme and GGTI-286. Thus we suggested geranylgeranylation-dependent RhoA/Rho kinase activation was involved in alendronate-me...
作者:Xuhua Yu , Jiajun Xu , Wenwu Liu ...
来源:[J].Cellular Physiology and Biochemistry(IF 3.415), 2018, Vol.46 (3), pp.965-974DOAJ
摘要:... Protein levels of phospho-myosin light chain (MLC, a Rho kinase substrate) and phospho-extracellular signal-regulated kinase 1 or 2 (ERK1/2) were determined by western blotting. The score of actin colocalization was assessed by phalloidin-FITC using an immunofluorescent micro...
作者:Ying Zhang , Linpei Jia , Wei Ji ...
来源:[J].Cellular Physiology and Biochemistry(IF 3.415), 2018, Vol.48 (1), pp.348-360DOAJ
摘要:Background/Aims: The role of the RhoA/Rho kinase signaling pathway in diabetes mellitus-induced erectile dysfunction has been partially understood. Methods: In the present study, we explored the changes of the RhoA/Rho associated kinase (ROCK) signaling pathway in diabetic er...

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