全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Brittany Salter , Cara Pray , Katherine Radford ...
来源:[J].Respiratory Research(IF 3.642), 2017, Vol.18 (1)Springer
摘要:Airway remodelling is an important feature of asthma pathogenesis. A key structural change inherent in airway remodelling is increased airway smooth muscle mass. There is emerging evidence to suggest that the migration of airway smooth muscle cells may contribute to cellular hype...
作者:Laura Lucarini , Alessandro Pini , Elisabetta Gerace ...
来源:[J].Journal of Cellular and Molecular Medicine(IF 4.753), 2014, Vol.18 (3), pp.468-479Wiley
摘要:Abstract(#br)Activation of poly( ADP ‐ribose) polymerases ( PARP s) is considered a key event in the molecular and cellular processes leading from acute asthma attacks to bronchial hyper‐reactivity, leucocyte recruitment, chronic inflammation, airway remodelling and lung ...
作者:Mark Kuehnel , Lavinia Maegel , Jens Vogel-Claussen ...
来源:[J].Cell and Tissue Research(IF 3.677), 2017, Vol.367 (3), pp.663-675Springer
摘要:Abstract(#br)Following lung transplantation, fibrotic remodelling of the small airways has been recognized for almost 5 decades as the main correlate of chronic graft failure and a major obstacle to long-term survival. Mainly due to airway fibrosis, pulmonary allografts currently...
作者:Michael Roth , Jun Zhong , Celine Zumkeller ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (2)DOAJ
摘要:BACKGROUND: In allergic asthma, IgE increases airway remodelling but the mechanism is incompletely understood. Airway remodelling consists of two independent events increased cell numbers and enhanced extracellular matrix deposition, and the mechanism by which IgE up-regulates ce...
作者:Ping Huang , Yan Li , Ze Lv ...
来源:[J].Respirology(IF 2.781), 2017, Vol.22 (1), pp.78-85Wiley
摘要:... Using an established IL ‐25‐induced murine model of asthma, we undertook a comprehensive evaluation of the effects of co‐administered LY294002 , a pharmacological pan‐inhibitor of PI3K on IL ‐25‐induced changes on this model, with particular regard to airway remodelling...
作者:David B. Wright , Herman Meurs , Bart G.J. Dekkers
来源:[J].Trends in Pharmacological Sciences(IF 9.25), 2014, Vol.35 (11), pp.567-574Elsevier
摘要:... Airway remodelling is another pathological feature of asthma that is thought to make an important contribution to airway hyperresponsiveness (AHR) and lung function decline. Recent studies have identified integrins as important players in this process, with a particular role...
作者:L. Manso , M. Reche , M.A. Padial ...
来源:[J].Allergologia et Immunopathologia(IF 1.229), 2012, Vol.40 (2), pp.108-116Elsevier
摘要:Abstract(#br)Asthma is an inflammatory disease of the lower airways characterised by the presence of airway inflammation, reversible airflow obstruction and airway hyperresponsiveness and alterations on the normal structure of the airways, known as remodelling. Remodelling is cha...
作者:Nguyen Van Tho , Yasushi Ryujin , Emiko Ogawa ...
来源:[J].Respirology(IF 2.781), 2015, Vol.20 (4), pp.594-601Wiley
摘要:Abstract(#br)Background and objective(#br)The relative contributions of emphysema and airway remodelling to airflow limitation remain unclear in chronic obstructive pulmonary disease ( COPD ). We aimed to evaluate the relative contributions of emphysema and airway wall thickness...
作者:Robyn L. Jones , Peter B. Noble , John G. Elliot ...
来源:[J].Respirology(IF 2.781), 2016, Vol.21 (8), pp.1347-1356Wiley
摘要:... This is called ‘airway hyperresponsiveness’ ( AHR ) and is associated with thickening of the airway wall, predominantly the layer of airway smooth muscle, due to more cells, bigger cells and more extracellular matrix ( ECM ) in proportion to the increase in smooth musc...
作者:John G. Elliot , Robyn L. Jones , Michael J. Abramson ...
来源:[J].Respirology(IF 2.781), 2015, Vol.20 (1), pp.66-72Wiley
摘要:Abstract(#br)Background and objective(#br)Pathological phenotypes of asthma have been based predominantly on inflammation, rather than airway wall remodelling. Differences in the distribution of airway smooth muscle ( ASM ) remodelling between large and small airways may affec...

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