全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Kyle J. Nakamura , Laura Heath , Edwin R. Sobrera ...
来源:[J].Retrovirology(IF 5.657), 2017, Vol.14 (1)Springer
摘要:Mother-to-child transmission of human immunodeficiency virus-type 1 (HIV-1) poses a serious health threat in developing countries, and adequate interventions are as yet unrealized. HIV-1 infection is frequently initiated by a single founder viral variant, but the factors that inf...
作者:Nadine Bachmann , Teja Turk , Claus Kadelka ...
来源:[J].Retrovirology(IF 5.657), 2017, Vol.14 (1)Springer
摘要:Parent-offspring (PO) regression is a central tool to determine the heritability of phenotypic traits; i.e., the relative extent to which those traits are controlled by genetic factors. The applicability of PO regression to viral traits is unclear because the direction of vi...
作者:Bep Klaver , Yme van der Velden , Formijn van Hemert ...
来源:[J].Retrovirology(IF 5.657), 2017, Vol.14 (1)Springer
摘要:The HIV-1 RNA genome has a biased nucleotide composition with a surplus of As. Several hypotheses have been put forward to explain this striking phenomenon, but the A-count of the HIV-1 genome has thus far not been systematically manipulated. The reason for this reservation is th...
作者:Fabienne De Oliveira , Thomas Mourez , Aurélia Vessiere ...
来源:[J].Retrovirology(IF 5.657), 2017, Vol.14 (1)Springer
摘要:Due to the prevalence of HIV-1 group M and the endemicity of HIV-1 group O infections in Cameroon, patients may be infected with both viruses and/or with HIV-1/MO recombinant forms. Such atypical infections may be deleterious in terms of diagnosis and therapeutic management due t...
作者:Chijioke N. Umunnakwe , Karin S. Dorman , Drena Dobbs ...
来源:[J].Retrovirology(IF 5.657), 2017, Vol.14 (1)Springer
摘要:Rev-like proteins are post-transcriptional regulatory proteins found in several retrovirus genera, including lentiviruses, betaretroviruses, and deltaretroviruses. These essential proteins mediate the nuclear export of incompletely spliced viral RNA, and act by tethering viral pr...
作者:Manjusha M. Kulkarni , Annette N. Ratcliff , Menakshi Bhat ...
来源:[J].Retrovirology(IF 5.657), 2017, Vol.14 (1)Springer
摘要:Like all viruses, HIV-1 relies on host systems to replicate. The human purinome consists of approximately two thousand proteins that bind and use purines such as ATP, NADH, and NADPH. By virtue of their purine binding pockets, purinome proteins are highly druggable, and many exis...
作者:Cancan Chen , Xiaocao Ma , Qifei Hu ...
来源:[J].Retrovirology(IF 5.657), 2017, Vol.14 (1)Springer
摘要:MOV10 protein has ATP-dependent 5′–3′ RNA helicase activity and belongs to the UPF1p superfamily. It can inhibit human immunodeficiency virus type 1 (HIV-1) replication at multiple stages and interact with apolipoprotein-B-mRNA-editing enzyme catalytic polypeptide-like ...
作者:Guoli Shi , Olivier Schwartz , Alex A. Compton
来源:[J].Retrovirology(IF 5.657), 2017, Vol.14 (1)Springer
摘要:The first responders of human antiviral immunity are components of the intrinsic immune response that reside within each and every one of our cells. This cell-autonomous arsenal consists of nucleic acid sensors and antiviral effectors strategically placed by evolution to detect a...
作者:Shiyou Chen , Xiaodan Yang , Weijia Cheng ...
来源:[J].Retrovirology(IF 5.657), 2017, Vol.14 (1)Springer
摘要:A20-binding inhibitor of NF-κB activation (ABIN1), an important immune regulator, was previously shown to be involved in HIV-1 replication. However, the reported studies done with overexpressed ABIN1 provided controversial results.
作者:Mohamed S. Benleulmi , Julien Matysiak , Xavier Robert ...
来源:[J].Retrovirology(IF 5.657), 2017, Vol.14 (1)Springer
摘要:Stable insertion of the retroviral DNA genome into host chromatin requires the functional association between the intasome (integrase·viral DNA complex) and the nucleosome. The data from the literature suggest that direct protein–protein contacts between integrase and histon...

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