全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Graham Rena , D. Grahame Hardie , Ewan R. Pearson
来源:[J].Diabetologia(IF 6.487), 2017, Vol.60 (9), pp.1577-1585Springer
摘要:Metformin is a widely-used drug that results in clear benefits in relation to glucose metabolism and diabetes-related complications. The mechanisms underlying these benefits are complex and still not fully understood. Physiologically, metformin has been shown to reduce hepatic gl...
作者:Lucia Russo , Harrison T. Muturi , Hilda E. Ghadieh ...
来源:[J].Diabetologia(IF 6.487), 2017, Vol.60 (12), pp.2463-2474Springer
摘要:The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes insulin clearance. Mice with global null mutation ( Cc1 −/−) or with liver-specific inactivation (L-SACC1) of Cc1 (also known as Ceacam1 ) gene display hyperinsulinaemia resulting fro...
作者:Giuseppe Penno , Eleonora Russo , Monia Garofolo ...
来源:[J].Diabetologia(IF 6.487), 2017, Vol.60 (6), pp.1102-1113Springer
摘要:In a retrospective, observational, cross-sectional, single-centre study, we assessed the prevalence and correlates of different CKD phenotypes (with and without albuminuria) in a large cohort of patients of white ethnicity with type 1 diabetes.
作者:Sarah M. Gray , Kevin W. Aylor , Eugene J. Barrett
来源:[J].Diabetologia(IF 6.487), 2017, Vol.60 (8), pp.1512-1521Springer
摘要:For circulating insulin to act on the brain it must cross the blood–brain barrier (BBB). Remarkably little is known about how circulating insulin crosses the BBB’s highly restrictive brain endothelial cells (BECs). Therefore, we examined potential mechanisms regulating BEC i...
作者:Morten A. Karsdal , Kim Henriksen , Federica Genovese ...
来源:[J].Diabetologia(IF 6.487), 2017, Vol.60 (1), pp.50-59Springer
摘要:The treatment of type 2 diabetes with full peroxisome proliferator-activated receptor gamma (PPARγ) agonists improves insulin sensitivity, but is associated with weight gain, heart failure, peripheral oedema and bone loss. Endotrophin, the C-terminal fragment of the α3 chain...
作者:Mads V. Svart , Nikolaj Rittig , Ulla Kampmann ...
来源:[J].Diabetologia(IF 6.487), 2017, Vol.60 (7), pp.1197-1206Springer
摘要:Diabetic ketoacidosis (DKA) is often caused by concomitant systemic inflammation and lack of insulin. Here we used an experimental human model to test whether and how metabolic responses to insulin are impaired in the early phases of DKA with a specific focus on skeletal muscle m...
作者:Feng-Cheng Chou , Heng-Yi Chen , Hsin-Hui Chen ...
来源:[J].Diabetologia(IF 6.487), 2017, Vol.60 (12), pp.2409-2417Springer
摘要:The relative contribution of T helper (Th)1 and Th17 cells in graft rejection is inconclusive, on the basis of evidence provided by different T cell-related cytokine-deficient animal models and graft types.
作者:Giles S. H. Yeo
来源:[J].Diabetologia(IF 6.487), 2017, Vol.60 (5), pp.778-783Springer
摘要:At one level, obesity is clearly a problem of simple physics, a result of eating too much and not expending enough energy. The more complex question, however, is why do some people eat more than others? Studies of human and mouse genetics over the past two decades have uncov...

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