全部文献期刊会议图书|学者科研项目
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作者:Naaz Andharia , Ancy Joseph , Mikio Hayashi ...
来源:[J].Channels(IF 2.159), 2017, Vol.11 (3), pp.224-235
摘要:ABSTRACT(#br)The TREK-1 channel, the TWIK-1-related potassium (K+) channel, is a member of a family of 2-pore-domain K+ (K2P) channels, through which background or leak K+ currents occur. An interesting feature of the TREK-1 channel is the ru...
作者:Zhang , Ye , Huang ...
来源:[J].Channels(IF 2.159), 2019, Vol.13 (1), pp.235-246
摘要:ABSTRACT(#br)Pulmonary hypertension (PH) is a pathological state defined by increased pulmonary artery pressure, the pathogenesis of which is related to genetic mutations, intracellular calcium ([Ca2+]i), inflammation and proliferation. Transient receptor potential van...
作者:N. Bavi , O. Bavi , M. Vossoughi ...
来源:[J].Channels(IF 2.159), 2017, Vol.11 (3), pp.209-223
摘要:ABSTRACT(#br)Gating of mechanosensitive (MS) channels is driven by a hierarchical cascade of movements and deformations of transmembrane helices in response to bilayer tension. Determining the intrinsic mechanical properties of the individual transmembrane helices is therefo...
作者:Ben Katz , Olaf Voolstra , Hanan Tzadok ...
来源:[J].Channels(IF 2.159), 2017, Vol.11 (6), pp.678-685
摘要:ABSTRACT(#br) Drosophila photoreceptors respond to oscillating light of high frequency (∼100 Hz), while increasing the oscillating light intensity raises the maximally detected frequency. Recently, we reported that dephosphorylation of the light-activated TRP ion channel at ...
作者:Arima , Tsutsui , Okamura
来源:[J].Channels(IF 2.159), 2018, Vol.12 (1), pp.240-248
摘要:ABSTRACT(#br)Cation channel of Spermatozoa (CatSper) is one of the voltage-gated ion channels consisting of voltage sensor domains (VSDs) and pore-gate domains. CatSper is exclusively expressed in spermatozoa and indispensable for Ca2+ influx into cytosol. Recently, we...
作者:Romero-Romero , Martínez-Delgado , Balleza
来源:[J].Channels(IF 2.159), 2019, Vol.13 (1), pp.382-399
摘要:ABSTRACT(#br)In the preceding article, we present a flexibility analysis of the voltage-gated ion channel (VGIC) superfamily. In this study, we describe in detail the flexibility profile of the voltage-sensor domain (VSD) and the pore domain (PD) concerning the evolution of 6TM i...
作者:Hill , Ben-Shahar
来源:[J].Channels(IF 2.159), 2018, Vol.12 (1), pp.262-275
摘要:ABSTRACT(#br)Degenerin/Epithelial Sodium Channels (DEG/ENaCs) are a large family of animal-specific non-voltage gated ion channels, with enriched expression in neuronal and epithelial tissues. While neuronal DEG/ENaCs were originally characterized as sensory receptor channels, re...
作者:Pinggera , Negro , Tuluc ...
来源:[J].Channels(IF 2.159), 2018, Vol.12 (1), pp.388-402
摘要:ABSTRACT(#br)Recently, we and others identified somatic and germline de novo gain-of-function mutations in CACNA1D , the gene encoding the α1-subunit of voltage-gated Cav1.3 Ca2+-channels. While somatic mutations identified in aldosterone producing aden...

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