全部文献期刊会议图书|学者科研项目
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作者:James Monslow , Leslie Todd , John E. Chojnowski ...
来源:[J].The American Journal of Pathology(IF 4.522), 2020
摘要:Fibroblast activation protein (FAP) has been established as an inducible and mesenchymal cell-specific mediator of disease progression in cancer and fibrosis. Atherosclerosis is a fibroinflammatory disease, and FAP was previously reported to be up-regulated in human atherosc...
作者:Catherine B. Xie , Dan Jane-wit , Jordan S. Pober
来源:[J].The American Journal of Pathology(IF 4.522), 2020
摘要:Abstract(#br)The complement membrane attack complex (MAC) is classically known as a cytolytic effector of innate and adaptive immunity that forms pores in the plasma membrane of pathogens or targeted cells leading to osmolysis. Nucleated cells resist MAC-mediated cytolysis b...
作者:Allan Rasmusson , Dovile Zilenaite , Ausrine Nestarenkaite ...
来源:[J].The American Journal of Pathology(IF 4.522), 2020
摘要:Abstract(#br)The distribution of tumor infiltrating lymphocytes (TIL) within the tumor microenvironment provides strong prognostic value, which is increasingly important with the arrival of new immunotherapy modalities. Both visual and image analysis based assays are develop...
作者:Kazuhisa Ishida , Hiroyuki Tomita , Tomohiro Kanayama ...
来源:[J].The American Journal of Pathology(IF 4.522), 2020
摘要:Abstract(#br)The cyclin dependent kinase inhibitor 2A (CDKN2A)/alternate reading frame (ARF) locus consists of two overlapping tumor suppressor genes, p16INK4a and p14ARF (p19Arf in mice), encoding two unrelated proteins in alternative reading frames. Previous reports sugges...
作者:Jun Shiozawa , Susana de Vega , Mehmet Z. Cilek ...
来源:[J].The American Journal of Pathology(IF 4.522), 2020
摘要:Cell migration-inducing hyaluronidase 1 (CEMIP), also known as hyaluronan (HA)-binding protein involved in HA depolymerization (HYBID), plays a role in HA degradation. CEMIP2, also known as transmembrane protein 2 (TMEM2), possessing a sequence similarity with HYBID, is repo...
作者:Guangbi Li , Jason Kidd , Cristin Kaspar ...
来源:[J].The American Journal of Pathology(IF 4.522), 2020
摘要:ABSTRACT(#br)Lysosomal acid ceramidase (Ac) has been shown to be critical for ceramide hydrolysis and regulation of lysosome function and cellular homeostasis. In the present study, we generated a knockout mouse line (Asah1 fl/fl /Podo Cre ) with a podocyte-specific deletion of t...
作者:Michael S. Goligorsky
来源:[J].The American Journal of Pathology(IF 4.522), 2020
摘要:ABSTRACT(#br)Chronic kidney disease, commonly fostering non-renal complications, themselves more life-threatening than renal pathology, remain enigmatic. Despite more than a century of intense research, therapeutic options to halt or reverse renal disease are rather limited. Rece...
作者:Marloes Imke Hofstee , Gowrishankar Muthukrishnan , Gerald James Atkins ...
来源:[J].The American Journal of Pathology(IF 4.522), 2020
摘要:Abstract(#br)Osteomyelitis is an inflammation of the bone and bone marrow that is most commonly caused by a Staphylococcus aureus infection. Much of our understanding of the underlying pathophysiology of osteomyelitis, from the perspective of both host and pathogen, has been revi...
作者:Hanan H. Wahid , Peck Yin Chin , David J. Sharkey ...
来源:[J].The American Journal of Pathology(IF 4.522), 2020
摘要:Spontaneous preterm labor is frequently caused by an inflammatory response in the gestational tissues elicited by either infectious or sterile agents. In sterile preterm labor, the key regulators of inflammation are not identified, but platelet-activating factor (PAF) is implicat...

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