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作者:Martinez Marilyn N , Jelliffe Roger W , Proost Johannes H
来源:[J].The AAPS journal(IF 4.386), 2020, Vol.22 (2), pp.25
摘要:This article provides a dialogue covering an ongoing controversy on the use of clearance versus rate constant approaches for model parameterization when assessing pharmacokinetic (PK) data. It reflects the differences in opinions that can exist among PK experts. Importantly, this...
作者:Nguyen Ly Minh , Meaney Calvin J , Rao Gauri G ...
来源:[J].The AAPS journal(IF 4.386), 2020, Vol.22 (2), pp.40
摘要:Shortened red blood cell (RBC) lifespan is one of the major factors contributing to anemia in end-stage renal disease (ESRD) patients and should be taken into account in anemia management protocols. In this study, we aimed to estimate RBC lifespan and the source of between-subjec...
作者:Li Rui , Mathialagan Sumathy , Novak Jonathan J ...
来源:[J].The AAPS journal(IF 4.386), 2020, Vol.22 (2), pp.20
摘要:Active uptake mediated by organic anion transporter 2 (OAT2) has been previously hypothesized as a key player in hepatic disposition of its substrates. Previous studies have shown that another hepatic uptake transporter, organic anion transporting polypeptides (OATP) 1B1, signifi...
作者:Zhong Zhandong Don , Jiang Lynn L , Khandelwal Puneet ...
来源:[J].The AAPS journal(IF 4.386), 2020, Vol.22 (2), pp.36
摘要:Biologics can potentially induce unwanted immune responses, leading to formation of antidrug antibodies (ADA) of various affinity, isotypes, and subclasses. Among them, antigen and drug-specific immunoglobulin E (IgE) antibodies have been reported to have potential correlation wi...
作者:Yang Wenzhan , Gadgil Prajakta , Krishnamurthy Venkata R ...
来源:[J].The AAPS journal(IF 4.386), 2020, Vol.22 (2), pp.21
摘要:The druggability and developability space is rapidly evolving in the post-genomic era. In the past, Lipinski's rule-of-five (Ro5) emerged and served as a guide for drug-like molecule design for oral delivery in the traditional druggable target space. In contrast, in this new era,...
作者:Riglet François , Mentre France , Veyrat-Follet Christine ...
来源:[J].The AAPS journal(IF 4.386), 2020, Vol.22 (2), pp.50
摘要:Given a joint model and its parameters, Bayesian individual dynamic prediction (IDP) of biomarkers and risk of event can be performed for new patients at different landmark times using observed biomarker values. The aim of the present study was to compare IDP, with uncertainty, u...
作者:Gorovits Boris , Fiscella Michele , Havert Mike ...
来源:[J].The AAPS journal(IF 4.386), 2020, Vol.22 (2), pp.42
摘要:The first author's name was published incorrectly as "Gorovits Boris". The correct name is "Boris Gorovits".
作者:Guerrero Yadir A , Desai Diti , Sullivan Connor ...
来源:[J].The AAPS journal(IF 4.386), 2020, Vol.22 (2), pp.53
摘要:Static in vitro cell culture studies cannot capture the dynamic concentration profiles of drugs, nutrients, and other factors that cells experience in physiological systems. This limits the confidence in the translational relevance of in vitro experiments and increases the relian...
作者:Williams Jason H , Udata Chandrasekhar , Ganguly Bishu J ...
来源:[J].The AAPS journal(IF 4.386), 2020, Vol.22 (2), pp.23
摘要:IL-7 receptor-α (IL-7Rα) blockade has been shown to reverse autoimmune diabetes in the non-obese diabetic mouse by promoting inhibition of effector T cells and consequently altering the balance of regulatory T (Treg) and effector memory (TEM) cells. PF-...
作者:Gorovits Boris , Fiscella Michele , Havert Mike ...
来源:[J].The AAPS journal(IF 4.386), 2020, Vol.22 (2), pp.24
摘要:Viral vector-based gene therapies (GTx) have received significant attention in the recent years and the number of ongoing GTx clinical trials is increasing. A platform of choice for many of these studies is adeno-associated virus (AAV). All humans may be exposed to natural AAV in...

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