全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Nishit B. Modi
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (3), pp.607-618Springer
摘要:Increasing costs in discovering and developing new molecular entities and the continuing debate on limited company pipelines mean that pharmaceutical companies are under significant pressure to maximize the value of approved products. Life cycle management in the context of drug ...
作者:Eric Wakshull , Valerie Quarmby , Hanns-Christian Mahler ...
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (6), pp.1656-1668Springer
摘要:Therapeutic breakthroughs in a number of retinal degenerative diseases have come about through the development of biotherapeutics administered directly into the eye. As a consequence of their use, we have gained more insight into the immune privileged status of the eye and the va...
作者:Alexander G. Zestos , Robert T. Kennedy
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (5), pp.1284-1293Springer
摘要:Microdialysis is a powerful sampling technique used to monitor small molecules in vivo . Despite the many applications of microdialysis sampling, it is limited by the method of analyzing the resulting samples. An emerging technique for analysis of microdialysis samples is liquid ...
作者:Cordula Stillhart , Neil J. Parrott , Marc Lindenberg ...
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (3), pp.827-836Springer
摘要:The study aimed to characterise the mechanism of release and absorption of Basmisanil, a biopharmaceutics classification system (BCS) class 2 compound, from immediate-release formulations via mechanistic absorption modelling, dissolution testing, and Raman imaging. An oral a...
作者:Tiejun Cheng , Ming Hao , Takako Takeda ...
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (5), pp.1264-1275Springer
摘要:The prediction of drug-target interactions (DTIs) is of extraordinary significance to modern drug discovery in terms of suggesting new drug candidates and repositioning old drugs. Despite technological advances, large-scale experimental determination of DTIs is still expensive an...
作者:Jeffrey J. Lochhead , Patrick T. Ronaldson , Thomas P. Davis
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (4), pp.910-920Springer
摘要:A functional blood-brain barrier (BBB) is necessary to maintain central nervous system (CNS) homeostasis. Many diseases affecting the CNS, however, alter the functional integrity of the BBB. It has been shown that various diseases and physiological stressors can impact the B...
作者:Stephanie Fraser , Judy Y. Shih , Mark Ware ...
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (3), pp.682-691Springer
摘要:Numerous advances in ligand binding assay (LBA) real-time measurement technologies have been made within the last several years, ranging from the development of novel platforms to drive technology expansion to the adaptation of existing platforms to optimize performance and throu...
作者:Soheila Ali Akbari Ghavimi , Rama Rao Tata , Andrew J. Greenwald ...
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (4), pp.1029-1044Springer
摘要:Due to the growing number of patients suffering from musculoskeletal defects and the limited supply of and sub-optimal outcomes associated with biological graft materials, novel biomaterials must be created that can function as graft substitutes. For bone regeneration, composite ...
作者:Yi-an Bi , Renato J. Scialis , Sarah Lazzaro ...
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (3), pp.787-796Springer
摘要:Transporter-mediated hepatic uptake is proven to be the rate-determining step in the systemic clearance of several drugs. Therefore, accurate measurement of active and passive uptake clearances in vitro is critical to facilitate pharmacokinetics and drug-drug interaction pre...
作者:Andre Hermans , Andreas M. Abend , Filippos Kesisoglou ...
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (6), pp.1537-1549Springer
摘要:This manuscript represents the perspective of the Dissolution Analytical Working Group of the IQ Consortium. The intent of this manuscript is to highlight the challenges of, and to provide a recommendation on, the development of clinically relevant dissolution specifications (CRS...

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