全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Lingru Li , Juan Feng , Haiqiang Yao ...
来源:[J].Science China Life Sciences(IF 2.024), 2017, Vol.60 (1), pp.105-107Springer
摘要:Abstract(#br)
作者:Xin Fang , Xiao-Ya Chen
来源:[J].Science China Life Sciences(IF 2.024), 2017, Vol.60 (1), pp.108-110Springer
作者:Feiyu Li , Xiaoying Wang
来源:[J].Science China Life Sciences(IF 2.024), 2017, Vol.60 (1), pp.23-27Springer
摘要:Abstract(#br)The assessment and management of early-stage atherosclerosis are important for the prevention of cardiovascular disease (CVD). In this study, we used multi-contrast magnetic resonance imaging (MRI) to investigate the carotid plaque feature in asymptomatic, at-risk su...
作者:Zongzhe Li , Chengming Zhou , Lun Tan ...
来源:[J].Science China Life Sciences(IF 2.024), 2017, Vol.60 (1), pp.57-65Springer
摘要:Abstract(#br)Aortic dissection (AD) is a devastating, heterogeneous condition of aorta. The homeostasis between collagens and matrix metalloproteases (MMPs)/tissue inhibitors of MMPs (TIMPs) system in the extracellular matrix plays an important role for structure and functio...
作者:Yuting Chen , Wenqing Lu , Na Gao ...
来源:[J].Science China Life Sciences(IF 2.024), 2017, Vol.60 (2), pp.152-157Springer
摘要:Abstract(#br)The laboratory rat is a valuable mammalian model organism for basic research and drug discovery. Here we demonstrate an efficient methodology by applying transcription activator-like effector nucleases (TALENs) technology to generate Leptin receptor ( Lepr ) knockout...
作者:Xiaolu Zhao , Yuanyuan Wang , Yurui Wang ...
来源:[J].Science China Life Sciences(IF 2.024), 2017, Vol.60 (3), pp.264-270Springer
摘要:Abstract(#br)DNA replication elongation is tightly controlled by histone-modifying enzymes. Our previous studies showed that the histone methytransferase TXR1 ( Tetrahymena Trithorax related protein 1) specifically catalyzes H3K27 monomethylation and affects DNA replication elong...
作者:Jiaqi Lu , Qing Xia , Qiao Zhou
来源:[J].Science China Life Sciences(IF 2.024), 2017, Vol.60 (3), pp.239-248Springer
摘要:Abstract(#br)Around 400 million people worldwide suffer from diabetes mellitus. The major pathological event for Type 1 diabetes and advanced Type 2 diabetes is loss or impairment of insulin-secreting β cells of the pancreas. For the past 100 years, daily insulin injection h...
作者:Jian Lu , TongGui Ding , Xuan Qin ...
来源:[J].Science China Life Sciences(IF 2.024), 2017, Vol.60 (2), pp.215-224Springer
摘要:Abstract(#br)This study explored the effects of cucurbitacin E (CuE), a bioactive compound from Cucurbitaceae , on the metabolism/pharmacokinetic of tolbutamide, a model CYP2C9/11 probe substrate, and hepatic CYP2C11 expression in rats. Liquid chromatography-(tandem) mass sp...
作者:Meng Wu , Wei Wei , Jiwei Chen ...
来源:[J].Science China Life Sciences(IF 2.024), 2017, Vol.60 (2), pp.138-151Springer
摘要:Abstract(#br)Histone methylation is believed to provide binding sites for specific reader proteins, which translate histone code into biological function. Here we show that a family of acidic domain-containing proteins including nucleophosmin (NPM1), pp32, SET/TAF1β, nucleol...

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