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来源:[J].Proceedings of the National Academy of Sciences of the United States of America(IF 9.737), 2017, Vol.114 (30), pp.8029-8034JSTOR
摘要:GAS2L3 is a recently identified cytoskeleton-associated protein that interacts with actin filaments and tubulin. The in vivo function of GAS2L3 in mammals remains unknown. Here, we show that mice deficient in GAS2L3 die shortly after birth because of heart failure. Mammalian card...
来源:[J].Proceedings of the National Academy of Sciences of the United States of America(IF 9.737), 2017, Vol.114 (7), pp.E1148-E1157JSTOR
摘要:Wnt signaling, named after the secreted proteins that bind to cell surface receptors to activate the pathway, plays critical roles both in embryonic development and the maintenance of homeostasis in many adult tissues. Two particularly important cellular programs orchestrate...
来源:[J].Proceedings of the National Academy of Sciences of the United States of America(IF 9.737), 2017, Vol.114 (7), pp.1578-1583JSTOR
摘要:We recently introduced a physically based approach to sequence comparison, the property factor method (PFM). In the present work, we apply the PFM approach to the study of a challenging set of sequences—the bacterial chemotaxis protein CheY, the N-terminal receiver domain of...
来源:[J].Proceedings of the National Academy of Sciences of the United States of America(IF 9.737), 2017, Vol.114 (41), pp.10978-10983JSTOR
摘要:Many species of bat emit acoustic signals and use information carried by echoes reflecting from nearby objects to navigate and forage. It is widely documented that echolocating bats adjust the features of sonar calls in response to echo feedback; however, it remains unknown ...
来源:[J].Proceedings of the National Academy of Sciences of the United States of America(IF 9.737), 2017, Vol.114 (49), pp.12882-12887JSTOR
摘要:A supramolecular system in which the concentration of a molecule is buffered over several orders of magnitude is presented. Molecular buffering is achieved as a result of competition in a ring–chain equilibrium of multivalent ureidopyrimidinone monomers and a monovalent naph...
来源:[J].Proceedings of the National Academy of Sciences of the United States of America(IF 9.737), 2017, Vol.114 (6), pp.1335-1340JSTOR
摘要:Membraneless organelles play a central role in the organization of protoplasm by concentrating macromolecules, which allows efficient cellular processes. Recent studies have shown that, in vitro, certain components in such organelles can assemble through phase separation. Inside ...
来源:[J].Proceedings of the National Academy of Sciences of the United States of America(IF 9.737), 2017, Vol.114 (30), pp.8065-8070JSTOR
摘要:Osteosarcoma occurs predominantly in children and young adults. High-grade tumors require multidisciplinary treatment consisting of chemotherapy in the neoadjuvant and adjuvant settings, along with surgical intervention. Despite this approach, death from respiratory failure ...
来源:[J].Proceedings of the National Academy of Sciences of the United States of America(IF 9.737), 2017, Vol.114 (14), pp.E2920-E2928JSTOR
摘要:Bacteria produce a diverse array of secondary metabolites that have been invaluable in the clinic and in research. These metabolites are synthesized by dedicated biosynthetic gene clusters (BGCs), which assemble architecturally complex molecules from simple building blocks. ...
来源:[J].Proceedings of the National Academy of Sciences of the United States of America(IF 9.737), 2017, Vol.114 (26), pp.E5034-E5041JSTOR
摘要:Deterministic lateral displacement (DLD) is a technique for size fractionation of particles in continuous flow that has shown great potential for biological applications. Several theoretical models have been proposed, but experimental evidence has demonstrated that a rich class o...

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