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作者:Mohammad Alsalem , Mansour Haddad , Sara A. Aldossary ...
来源:[J].PPAR Research(IF 2.685), 2019, Vol.2019
摘要:Neuropathic pain is a growing healthcare problem causing a global burden. Currently used analgesics such as opioids are associated with adverse effects; urging the need for safer alternatives. Here we aimed to investigate the potential analgesic effects of tesaglitazar; dual...
作者:Izabela Wojtkowska , Tomasz A. Bonda , Andrzej Tysarowski ...
来源:[J].PPAR Research(IF 2.685), 2019, Vol.2019
摘要:TNFα and PPARγ are important modulators of metabolism, inflammation, and atherosclerosis. Coronary artery disease is the leading cause of heart failure (HF). The aim of the study was to assess whether polymorphisms of the TNFα (-308G>A) and PPARG2 (Pro12Ala) genes are associ...
作者:Sarawin Harnchoowong , Poonkiat Suchonwanit
来源:[J].PPAR Research(IF 2.685), 2017, Vol.2017
摘要:Peroxisome proliferator-activated receptor γ (PPAR-γ) is a ligand-activated nuclear receptor that regulates the transcription of various genes. PPAR-γ plays roles in lipid homeostasis, sebocyte maturation, and peroxisome biogenesis and has shown anti-inflammatory effects. PP...
作者:Yong-Jik Lee , Yoo-Na Jang , Yoon-Mi Han ...
来源:[J].PPAR Research(IF 2.685), 2017, Vol.2017
摘要:To investigate the effects of fimasartan on nonalcoholic fatty liver disease in hyperlipidemic and hypertensive conditions, the levels of biomarkers related to fatty acid metabolism were determined in HepG2 and differentiated 3T3-L1 cells treated by high fatty acid and liver...
作者:Séverine A. Degrelle , Hussein Shoaito , Thierry Fournier
来源:[J].PPAR Research(IF 2.685), 2017, Vol.2017
摘要:The peroxisome-proliferator-activated-receptor-γ (PPARγ) is a member of the nuclear receptor superfamily that plays a critical role in diverse biological processes, including adipogenesis, lipid metabolism, and placental development. To study the activity of PPARγ, we constr...

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