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作者:Stefania Crotta , Sophia Davidson , Tanel Mahlakoiv ...
来源:[J].PLoS Pathogens(IF 8.136), 2017, Vol.9 (11)DOAJ
摘要:Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to specific receptors on the same or neighbouring cells to activate the expression of hundreds of IFN stimulated genes (ISGs)...
作者:Kouyuki Hirayasu , Jun Ohashi , Koichi Kashiwase ...
来源:[J].PLoS Pathogens(IF 8.136), 2017, Vol.8 (3)DOAJ
摘要:Cerebral malaria is a major, life-threatening complication of Plasmodium falciparum malaria, and has very high mortality rate. In murine malaria models, natural killer (NK) cell responses have been shown to play a crucial role in the pathogenesis of cerebral malaria. To investiga...
作者:Kay O Johswich , Shannon E McCaw , Epshita Islam ...
来源:[J].PLoS Pathogens(IF 9.127), 2017, Vol.9 (7)DOAJ
摘要:Neisseria meningitidis (Nme) asymptomatically colonizes the human nasopharynx, yet can initiate rapidly-progressing sepsis and meningitis in rare instances. Understanding the meningococcal lifestyle within the nasopharyngeal mucosa, a phase of infection that is prerequisite for d...
作者:Judith A Smith , Mike Khan , Diogo D Magnani ...
来源:[J].PLoS Pathogens(IF 9.127), 2017, Vol.9 (12)DOAJ
摘要:Brucella melitensis is a facultative intracellular bacterium that causes brucellosis, the most prevalent zoonosis worldwide. The Brucella intracellular replicative niche in macrophages and dendritic cells thwarts immune surveillance and complicates both therapy and vaccine develo...
作者:Kannan Venugopal , Elisabeth Werkmeister , Nicolas Barois ...
来源:[J].PLoS Pathogens(IF 9.127), 2017, Vol.13 (4)DOAJ
摘要:Toxoplasma gondii possesses a highly polarized secretory system, which efficiently assembles de novo micronemes and rhoptries during parasite replication. These apical secretory organelles release their contents into host cells promoting parasite invasion and survival. Using...
作者:Anica M Wandler , Karen Guillemin
来源:[J].PLoS Pathogens(IF 9.127), 2019, Vol.8 (10)DOAJ
摘要:Gastric cancer development is strongly correlated with infection by Helicobacter pylori possessing the effector protein CagA. Using a transgenic Drosophila melanogaster model, we show that CagA expression in the simple model epithelium of the larval wing imaginal disc causes dram...
作者:Nelson D Glennie , Susan W Volk , Phillip Scott
来源:[J].PLoS Pathogens(IF 9.127), 2017, Vol.13 (4)DOAJ
摘要:Tissue-resident memory T cells are required for establishing protective immunity against a variety of different pathogens, although the mechanisms mediating protection by CD4+ resident memory T cells are still being defined. In this study we addressed this issue with a popul...
作者:Maruti Nandan Rai , Sriram Balusu , Neelima Gorityala ...
来源:[J].PLoS Pathogens(IF 8.136), 2017, Vol.8 (8)DOAJ
摘要:Fungal septicemia is an increasingly common complication of immunocompromised patients worldwide. Candida species are the leading cause of invasive mycoses with Candida glabrata being the second most frequently isolated Candida species from Intensive Care Unit patients. Desp...
作者:Érika Machado de Salles , Maria Nogueira de Menezes , Renan Siqueira ...
来源:[J].PLoS Pathogens(IF 9.127), 2017, Vol.13 (8)DOAJ
摘要:A complete understanding of the mechanisms underlying the acquisition of protective immunity is crucial to improve vaccine strategies to eradicate malaria. However, it is still unclear whether recognition of damage signals influences the immune response to Plasmodium infecti...
作者:Sara Garamszegi , Eric A Franzosa , Yu Xia
来源:[J].PLoS Pathogens(IF 8.136), 2017, Vol.9 (12)DOAJ
摘要:A central challenge in host-pathogen systems biology is the elucidation of general, systems-level principles that distinguish host-pathogen interactions from within-host interactions. Current analyses of host-pathogen and within-host protein-protein interaction networks are large...

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