全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Saeed Omidi , Mihaela Zavolan , Mikhail Pachkov ...
来源:[J].PLOS Computational Biology(IF 5.215), 2017, Vol.13 (7)PLOS
摘要:Gene regulatory networks are ultimately encoded by the sequence-specific binding of (TFs) to short DNA segments. Although it is customary to represent the binding specificity of a TF by a position-specific weight matrix (PSWM), which assumes each position within a site contr...
作者:Nan Lin , Yun Zhu , Ruzong Fan ...
来源:[J].PLOS Computational Biology(IF 5.215), 2017, Vol.13 (10)PLOS
摘要:Investigating the pleiotropic effects of genetic variants can increase statistical power, provide important information to achieve deep understanding of the complex genetic structures of disease, and offer powerful tools for designing effective treatments with fewer side effects....
作者:Kalinga Pavan T. Silva , Prithiviraj Chellamuthu , James Q. Boedicker
来源:[J].PLOS Computational Biology(IF 5.215), 2017, Vol.13 (10)PLOS
摘要:In multispecies microbial communities, the exchange of signals such as acyl-homoserine lactones (AHL) enables communication within and between species of Gram-negative bacteria. This process, commonly known as quorum sensing, aids in the regulation of genes crucial for the surviv...
作者:Fayyaz ul Amir Afsar Minhas , Eric D. Ross , Asa Ben-Hur
来源:[J].PLOS Computational Biology(IF 5.215), 2017, Vol.13 (4)PLOS
摘要:Many prion-forming proteins contain glutamine/asparagine (Q/N) rich domains, and there are conflicting opinions as to the role of primary sequence in their conversion to the prion form: is this phenomenon driven primarily by amino acid composition, or, as a recent computational a...
作者:Jan Ewald , Martin Bartl , Thomas Dandekar ...
来源:[J].PLOS Computational Biology(IF 5.215), 2017, Vol.13 (2)PLOS
摘要:A precise and rapid adjustment of fluxes through metabolic pathways is crucial for organisms to prevail in changing environmental conditions. Based on this reasoning, many guiding principles that govern the evolution of metabolic networks and their regulation have been uncovered....
作者:Vijay Vedula , Juhyun Lee , Hao Xu ...
来源:[J].PLOS Computational Biology(IF 5.215), 2017, Vol.13 (10)PLOS
摘要:Blood flow and mechanical forces in the ventricle are implicated in cardiac development and trabeculation. However, the mechanisms of mechanotransduction remain elusive. This is due in part to the challenges associated with accurately quantifying mechanical forces in the developi...
作者:Noga Mosheiff , Haggai Agmon , Avraham Moriel ...
来源:[J].PLOS Computational Biology(IF 5.215), 2017, Vol.13 (6)PLOS
摘要:Grid cells in the entorhinal cortex encode the position of an animal in its environment with spatially periodic tuning curves with different periodicities. Recent experiments established that these cells are functionally organized in discrete modules with uniform grid spacin...
作者:Michal Bassani-Sternberg , Chloé Chong , Philippe Guillaume ...
来源:[J].PLOS Computational Biology(IF 5.215), 2017, Vol.13 (8)PLOS
摘要:The precise identification of Human Leukocyte Antigen class I (HLA-I) binding motifs plays a central role in our ability to understand and predict (neo-)antigen presentation in infectious diseases and cancer. Here, by exploiting co-occurrence of HLA-I alleles across ten newly gen...

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