全部文献期刊会议图书|学者科研项目
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作者:Wanzhen Li , Zhen Liu , Weining Sun ...
来源:[J].Neurobiology of Aging(IF 6.166), 2020, Vol.85, pp.156.e1-156.e4
摘要:Abstract(#br)Variants in exon 4 of gene encoding GLT8D1 (glycosyltransferase 8 domain containing 1) gene have recently been suggested as a novel cause of amyotrophic lateral sclerosis (ALS). In addition, there is a synergism between GLT8D1 and ARPP21 (cAMP Regulated Phosphop...
作者:Katherine J. Bangen , Kelsey R. Thomas , Alexandra J. Weigand ...
来源:[J].Neurobiology of Aging(IF 6.166), 2020, Vol.86, pp.134-142
摘要:Abstract(#br)White matter hyperintensities (WMHs), a marker of small-vessel cerebrovascular disease, increase risk for mild cognitive impairment (MCI). Less is known about whether regional WMHs distinguish MCI subtypes and predict decline in everyday functioning. About 618 Alzhei...
作者:Susanna C. Larsson , Per M. Roos
来源:[J].Neurobiology of Aging(IF 6.166), 2020, Vol.87, pp.140.e1-140.e3
摘要:Abstract(#br)We conducted a mendelian randomization study to investigate the association between serum 25-hydroxyvitamin D (S-25OHD) concentrations and amyotrophic lateral sclerosis (ALS). Summary-level data for genetic predictors of S-25OHD concentrations were acquired from...
作者:Qiongqiong Qiu , Longfei Jia , Qi Wang ...
来源:[J].Neurobiology of Aging(IF 6.166), 2020, Vol.85, pp.155.e1-155.e4
摘要:Abstract(#br)Presenilin 1 ( PSEN1 ), presenilin 2 ( PSEN2 ), and amyloid precursor protein ( APP ) genes account for the majority of autosomal dominant Alzheimer's disease (AD), with PSEN1 being the most common. We screened these genes for mutations in a Chinese proband from...
作者:Bryan J. Neth , Akiva Mintz , Christopher Whitlow ...
来源:[J].Neurobiology of Aging(IF 6.166), 2020, Vol.86, pp.54-63
摘要:Abstract(#br)There is currently no established therapy to treat or prevent Alzheimer’s disease. The ketogenic diet supplies an alternative cerebral metabolic fuel, with potential neuroprotective effects. Our goal was to compare the effects of a modified Mediterranean-ketogen...
作者:Kylie H. Alm , Andreia V. Faria , Abhay Moghekar ...
来源:[J].Neurobiology of Aging(IF 6.166), 2020, Vol.87, pp.78-88
摘要:Abstract(#br)Significant evidence demonstrates that aging is associated with variability in cognitive performance, even among individuals who are cognitively normal. In this study, we examined measures from magnetic resonance imaging and cerebrospinal fluid (CSF) to investigate w...
作者:Claudio Babiloni , Susanna Lopez , Claudio Del Percio ...
来源:[J].Neurobiology of Aging(IF 6.166), 2020
摘要:Abstract(#br)Cognitive reserve is present in Alzheimer's disease (AD) seniors with high education attainment making them clinically resilient to extended brain neuropathology and neurodegeneration. Here, we tested whether subjective memory complaint (SMC) seniors with AD neu...
作者:Panteleimon Giannakopoulos , Cristelle Rodriguez , Marie-Louise Montandon ...
来源:[J].Neurobiology of Aging(IF 6.166), 2020
摘要:Abstract(#br)The relationship between personality profiles and brain integrity in old age is still a matter of debate. We examined the association between Big Five factor and facet scores and MRI brain volume changes on a 54-month follow-up in 65 elderly controls with 3 neur...
作者:Morgane Perrotte , Mohamed Haddad , Aurélie Le Page ...
来源:[J].Neurobiology of Aging(IF 6.166), 2020, Vol.86, pp.102-111
摘要:Abstract(#br)Accumulating evidence suggests that the propagation of hyperphosphorylation of tau protein and the amyloid-β peptide can be mediated by extracellular vesicles (EVs) and be associated with the onset and the progression of Alzheimer's disease (AD). As EVs may tran...
作者:Oum Kaltoum Hassani , Vladimir V. Rymar , Khanh Q. Nguyen ...
来源:[J].Neurobiology of Aging(IF 6.166), 2020, Vol.85, pp.22-37
摘要:Abstract(#br)The cause of midbrain dopaminergic (mDA) neuron loss in sporadic Parkinson's disease (PD) is multifactorial, involving cell autonomous factors, cell-cell interactions, and the effects of environmental toxins. Early loss of neurons in the locus coeruleus (LC), the mai...

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