全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Clarence T. Sasaki , Sotirios G. Doukas , Dimitra P. Vageli
来源:[J].Neoplasia: An International Journal for Oncology Research, 2018, Vol.20 (4), pp.374-386DOAJ
摘要:PURPOSE: Bile-containing gastroesophageal reflux may promote cancer at extraesophageal sites. Acidic bile can accelerate NF-κB activation and molecular events, linked to premalignant changes in murine hypopharyngeal mucosa (HM). We hypothesize that short-term in vivo topical...
作者:Laura E. Pascal , Yao Wang , Mingming Zhong ...
来源:[J].Neoplasia: An International Journal for Oncology Research, 2018, Vol.20 (4), pp.351-363DOAJ
摘要:The tumor suppressor genes EAF2 and p53 are frequently dysregulated in prostate cancers. Recently, we reported that concurrent p53 nuclear staining and EAF2 downregulation were associated with high Gleason score. Combined loss of EAF2 and p53 in a murine model induced prosta...
作者:Ann-Kathrin Müller , Melanie Föll , Bianca Heckelmann ...
来源:[J].Neoplasia: An International Journal for Oncology Research, 2018, Vol.20 (2), pp.140-151DOAJ
摘要:Patients with metastatic prostate cancer (PCa) have a poorer prognosis than patients with organ-confined tumors. We strove to uncover the proteome signature of primary PCa and associated lymph node metastases (LNMs) in order to identify proteins that may indicate or potentially p...
作者:Lukas Krähenbühl , Simone M Goldinger , Joanna Mangana ...
来源:[J].Neoplasia: An International Journal for Oncology Research, 2018, Vol.20 (2), pp.218-225DOAJ
摘要:A deepened understanding of the cellular and molecular processes in the tumor microenvironment is necessary for the development of precision immunotherapy (IT). We simultaneously investigated CD3, PDL1, and IDO by immunohistochemistry in paired biopsies from various organs of 43 ...
作者:Tonje S. Steigedal , Jimita Toraskar , Richard P. Redvers ...
来源:[J].Neoplasia: An International Journal for Oncology Research, 2018, Vol.20 (4), pp.387-400DOAJ
摘要:Most cancer patients with solid tumors who succumb to their illness die of metastatic disease. While early detection and improved treatment have led to reduced mortality, even for those with metastatic cancer, some patients still respond poorly to treatment. Understanding the mec...
作者:Marianna Szemes , Alexander Greenhough , Zsombor Melegh ...
来源:[J].Neoplasia: An International Journal for Oncology Research, 2018, Vol.20 (4), pp.335-350DOAJ
摘要:Neuroblastoma is one of the commonest and deadliest solid tumours of childhood, and is thought to result from disrupted differentiation of the developing sympathoadrenergic lineage of the neural crest. Neuroblastoma exhibits intra- and intertumoural heterogeneity, with high ...
作者:Guanglin Xu , Ying Wang , Weijie Li ...
来源:[J].Neoplasia: An International Journal for Oncology Research, 2018, Vol.20 (4), pp.324-334DOAJ
摘要:COX-2 and YAP are shown to be highly associated with hepatocellular carcinoma (HCC) and frequently upregulated during tumor formation. However, despite their importance, whether there is a mutual interaction between COX-2 and YAP and how they regulate each other are not clea...
作者:AGM Mostofa , Surendra R. Punganuru , Hanumantha Rao Madala ...
来源:[J].Neoplasia: An International Journal for Oncology Research, 2018, Vol.20 (4), pp.305-323DOAJ
摘要:Whether the antimutagenic DNA repair protein MGMT works solo in human cells and if it has other cellular functions is not known. Here, we show that human MGMT associates with PCNA and in turn, with the cell cycle inhibitor, p21cip1 in glioblastoma and other cancer cell lines. MGM...
作者:Wei Tse Li , Hao Zheng , Vincent Nguyen ...
来源:[J].Neoplasia: An International Journal for Oncology Research, 2018, Vol.20 (4), pp.364-373DOAJ
摘要:Though bladder urothelial carcinoma is the most common form of bladder cancer, advances in its diagnosis and treatment have been modest in the past few decades. To evaluate miRNAs as putative disease markers for bladder urothelial carcinoma, this study develops a process to ident...

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