全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Unknown
来源:[J].Molecular Cancer Research(IF 4.353), 2015, Vol.13 (10), pp.1359-1359The Royal Society
作者:Tedeschi Philip M. , Vazquez Alexei , Kerrigan John E. ...
来源:[J].Molecular Cancer Research(IF 4.353), 2015, Vol.13 (10), pp.1361-1366The Royal Society
摘要:Rapidly proliferating tumors attempt to meet the demands for nucleotide biosynthesis by upregulating folate pathways that provide the building blocks for pyrimidine and purine biosynthesis. In particular, the key role of mitochondrial folate enzymes in providing formate for ...
作者:Fan Ping , Cunliffe Heather E. , Maximov Philipp Y. ...
来源:[J].Molecular Cancer Research(IF 4.353), 2015, Vol.13 (10), pp.1367-1376The Royal Society
摘要:Estrogen (E2) exerts a dual function on E2-deprived breast cancer cells, with both initial proliferation and subsequent induction of stress responses to cause apoptosis. However, the mechanism by which E2 integrally regulates cell growth or apoptosis-associated pathways rema...
作者:Tenkerian Clara , Krishnamoorthy Jothilatha , Mounir Zineb ...
来源:[J].Molecular Cancer Research(IF 4.353), 2015, Vol.13 (10), pp.1377-1388The Royal Society
摘要:The mTOR nucleates two complexes, namely mTOR complex 1 and 2 (mTORC1 and mTORC2), which are implicated in cell growth, survival, metabolism, and cancer. Phosphorylation of the α-subunit of translation initiation factor eIF2 at serine 51 (eIF2αS51P) is a key event of mRNA tr...
作者:Stachelek Gregory C. , Peterson-Roth Elizabeth , Liu Yanfeng ...
来源:[J].Molecular Cancer Research(IF 4.353), 2015, Vol.13 (10), pp.1389-1397The Royal Society
摘要:Radiotherapy and DNA-damaging chemotherapy are frequently utilized in the treatment of solid tumors. Innate or acquired resistance to these therapies remains a major clinical challenge in oncology. The development of small molecules that sensitize cancers to established ther...
作者:Ligumsky Hagai , Rubinek Tami , Merenbakh-Lamin Keren ...
来源:[J].Molecular Cancer Research(IF 4.353), 2015, Vol.13 (10), pp.1398-1407The Royal Society
摘要:Klotho is a transmembrane protein containing two internal repeats, KL1 and KL2, both displaying significant homology to members of the β-glycosidase family. Klotho is expressed in the kidney, brain, and various endocrine tissues, but can also be cleaved and act as a circulat...
作者:Kardos Gregory R. , Wastyk Hannah C. , Robertson Gavin P.
来源:[J].Molecular Cancer Research(IF 4.353), 2015, Vol.13 (10), pp.1408-1420The Royal Society
摘要:Many processes are deregulated in melanoma cells and one of those is protein production. Although much is known about protein synthesis in cancer cells, effective ways of therapeutically targeting this process remain an understudied area of research. A process that is upregu...
作者:Desnoyers Guillaume , Frost Laura D. , Courteau Lynn ...
来源:[J].Molecular Cancer Research(IF 4.353), 2015, Vol.13 (10), pp.1421-1430The Royal Society
摘要:The eIF3e protein is a component of the multisubunit eIF3 complex, which is essential for cap-dependent translation initiation. Decreased eIF3e expression is often observed in breast and lung cancer and has been shown to induce epithelial-to-mesenchymal transition (EMT) in b...
作者:Martin Neil E. , Gerke Travis , Sinnott Jennifer A. ...
来源:[J].Molecular Cancer Research(IF 4.353), 2015, Vol.13 (10), pp.1431-1440The Royal Society
摘要:Assessing the extent of PI3K pathway activity in cancer is vital to predicting sensitivity to PI3K-targeting drugs, but the best biomarker of PI3K pathway activity in archival tumor specimens is unclear. Here, PI3K pathway activation was assessed, in clinical tissue from 1,0...

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