全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Naglaa A. Attia , Alaa H. Sayed , Nadia S. Mahmoud ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2017, Vol.26 (10), pp.2614-2623Springer
摘要:Colon cancer accounts for about 500,000 death cases worldwide annually and represents approximately 6.5% of cancers in Egypt. This study employed a murine colon cancer model to identify the mechanism of the therapeutic value of gallic acid or ellagic acid against colon carcinogen...
作者:Alejandro Speck-Planche , M. Natália D. S. Cordeiro
来源:[J].Medicinal Chemistry Research(IF 1.612), 2017, Vol.26 (10), pp.2345-2356Springer
摘要:In this work, we introduce the first multitasking model for quantitative structure-biological effect relationships focused on the simultaneous exploration of antibacterial activity against Gram-negative pathogens and in vitro safety profiles related to absorption, distributi...
作者:Guanghui Tan , Qi Wang , Hongyue Zhang ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2017, Vol.26 (10), pp.2639-2652Springer
摘要:Chlorophyll has always been used as the leading compound for photodynamic therapy drug development. In this paper, a novel methyl pyropheophorbide-a- derived photosensitizer, 3-acetyl-3-devinyl-131-dicyanomethylene-pyropheophorbide-a was synthesized through modificatio...
作者:Oya Unsal-Tan , Keriman Ozadali-Sari , Beyza Ayazgok ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2017, Vol.26 (7), pp.1506-1515Springer
摘要:This study describes the synthesis, pharmacological evaluation, including acetylcholinesterase (AChE)/butyrylcholinesterase (BChE) inhibition, amyloid beta (Aβ) antiaggregation, and neuroprotective effects, as well as molecular modeling of novel 2-(4-substituted phenyl)-1 H ...
作者:Laiyin Zhang , Haiyang Zong , Huiping Lu ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2017, Vol.26 (10), pp.2468-2476Springer
摘要:A series of novel curcumin analogues were synthesized by optimization of its aromatic ring. The antiproliferative activities of these analogues were screened against four human cancer cell lines by MTT assay and some displayed significant improvement in antiproliferative act...
作者:Belén Rubio-Ruiz , Pablo Ríos-Marco , María Paz Carrasco-Jiménez ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2017, Vol.26 (11), pp.2809-2815Springer
摘要:Human choline kinase is a well validated target for the treatment of cancer. In the last two decades, many choline kinase inhibitors have been developed and one of them is currently under evaluation in clinical trials. In this paper a series of 6-(benzylthio)-9 H -purin-9-yl...
作者:Bhookya Shankar , Pochampally Jalapathi , Anil Valeru ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2017, Vol.26 (9), pp.1835-1846Springer
摘要:A novel series of 2-(6-alkyl-pyrazin-2-yl)-1 H -benzo[ d ]imidazole analogs (3a – 3j) derived from 2-(6-chloropyrazin-2-yl)-1 H -benzo[ d ]imidazole ( 2 ) by reacting with various substituted cyclic and acyclic secondary amines in presence of Pd-PEPPSI Mes catalyst by using ...
作者:Rajamanickam Pon Nivedha , Venkatesan Suryanarayanan , Chandrabose Selvaraj ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2017, Vol.26 (9), pp.1915-1925Springer
摘要:Prostate cancer is one of the frequently diagnosed cancers in men. In prostate cancer, initiation to the appearance of symptoms is a very long period. Due to its high latency period it paved the way for the chemoprevention. Chemopreventive drugs quickly and effectively eliminate ...
作者:Balraj Singh Gill , Navgeet , Sanjeev Kumar
来源:[J].Medicinal Chemistry Research(IF 1.612), 2017, Vol.26 (6), pp.1336-1348Springer
摘要:Cancer is a multifactorial disease with a network of genes causing genetic alterations. The sophisticated techniques in molecular biology revealed different cancer pathway, but their mechanistic approach is still shrouded. Tumor necrosis factor and TNF-related apoptosis-indu...
作者:Kadir Ay , Beyza Ispartaloğlu , Erkan Halay ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2017, Vol.26 (7), pp.1497-1505Springer
摘要:4-Sulfanilamido substitued-1,2,3-triazoles conjugated with monosaccharides ( 8 – 17 ) including d -glucose, d -galactose, d -mannose, and d -fructose were synthesized in good yields from azidosugars with propargyl sulfanilamides using copper catalyst 1,3-dipolar cycloadditio...

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