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作者:Mingxue Fan , Minghao Li , Lipeng Gao ...
来源:[J].Journal of Hematology & Oncology(IF 4.458), 2017, Vol.10 (1)Springer
摘要:Currently, conventional therapies for acute myeloid leukemia (AML) have high failure and relapse rates. Thus, developing new strategies is crucial for improving the treatment of AML. With the clinical success of anti-CD19 chimeric antigen receptor (CAR) T cell therapies against B...
作者:Bing Li , Robert Peter Gale , Zefeng Xu ...
来源:[J].Journal of Hematology & Oncology(IF 4.458), 2017, Vol.10 (1)Springer
摘要:We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm (MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential thrombocythemia myelofibrosis (post-PV/E...
作者:Sheng Chen , Feifei Gu , Kang Li ...
来源:[J].Journal of Hematology & Oncology(IF 4.458), 2017, Vol.10 (1)Springer
摘要:Adoptive transfer of cytotoxic T lymphocytes (CTLs) holds promises to cure cancer. However, this treatment is hindered by lacking a robust way to specifically expand out CTLs. Here, we developed a hybrid of B lymphoblastic cell line and T lymphoblastic cell line (T2 cells) as a s...
作者:Shengnan Yu , Anping Li , Qian Liu ...
来源:[J].Journal of Hematology & Oncology(IF 4.458), 2017, Vol.10 (1)Springer
摘要:Cancer immunotherapy is the most exciting advancement in cancer therapy. Similar to immune checkpoint blockade and chimeric antigen receptor T cell (CAR-T), bispecific antibody (BsAb) is attracting more and more attention as a novel strategy of antitumor immunotherapy. BsAb not o...
作者:Annie Im , Steven Z. Pavletic
来源:[J].Journal of Hematology & Oncology(IF 4.458), 2017, Vol.10 (1)Springer
摘要:The field of immunotherapy in cancer treatments has been accelerating over recent years and has entered the forefront as a leading area of ongoing research and promising therapies that have changed the treatment landscape for a variety of solid malignancies. Prior to its designat...
作者:Chau-To Kwok , Amy D. Marshall , John E. J. Rasko ...
来源:[J].Journal of Hematology & Oncology(IF 4.458), 2017, Vol.10 (1)Springer
摘要:Methylation of N6 adenosine (m6A) is known to be important for diverse biological processes including gene expression control, translation of protein, and messenger RNA (mRNA) splicing. However, its role in the development of human cancers is poorly understo...
作者:Dominique Farge , Lucas C. M. Arruda , Fanny Brigant ...
来源:[J].Journal of Hematology & Oncology(IF 4.458), 2017, Vol.10 (1)Springer
摘要:The determinants of clinical responses after autologous hematopoietic stem cell transplantation (aHSCT) in systemic sclerosis (SSc) are still unraveled. We analyzed long-term immune reconstitution (IR) and T cell receptor (TCR) repertoire diversity in 10 SSc patients, with a...
作者:Chao Huang , Xingruo Zeng , Guosong Jiang ...
来源:[J].Journal of Hematology & Oncology(IF 4.458), 2017, Vol.10 (1)Springer
摘要:The X-linked inhibitor of apoptosis protein (XIAP) is a well-known potent apoptosis suppressor and also participates in cancer cell biological behaviors, therefore attracting great attentions as a potential antineoplastic therapeutic target for past years. Anti-IAP therapy is rep...
作者:Liangshun You , Liping Mao , Juying Wei ...
来源:[J].Journal of Hematology & Oncology(IF 4.458), 2017, Vol.10 (1)Springer
摘要:T cells recognize antigen fragments from proteolytic products that are presented to them in the form of peptides on major histocompatibility complex (MHC) molecules, which is crucial for the T cell to identify infected or transformed cells. Autophagy, a process that delivers cyto...
作者:Rui-Hua Xu , Jin Li , Yuxian Bai ...
来源:[J].Journal of Hematology & Oncology(IF 4.458), 2017, Vol.10 (1)Springer
摘要:To assess the efficacy and safety of fruquintinib, a vascular endothelial growth factor receptor (VEGFR) inhibitor, in metastatic colorectal cancer (mCRC) patients.

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