全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Reema Roshan , Ashwani Choudhary , Aksheev Bhambri ...
来源:[J].Journal of Neuroinflammation(IF 4.351), 2017, Vol.14 (1)Springer
摘要:Polyglutamine diseases constitute a class of neurodegenerative disorders associated with expansion of the cytosine-adenine-guanine (CAG) triplet, in protein coding genes. Expansion of a polyglutamine tract in the N-terminal of TBP is the causal mutation in SCA17. Brain secti...
作者:Antje Vogelgesang , Claudia Lange , Lara Blümke ...
来源:[J].Journal of Neuroinflammation(IF 4.351), 2017, Vol.14 (1)Springer
摘要:Stroke induces immune alterations such as impaired oxidative burst and reduced release of neutrophil extracellular traps (NETs). We hypothesised that key enzymes of these defence mechanisms may be altered in ischaemic stroke. Therefore, we analysed the intra- and extracellular am...
作者:Lingling Sun , Rui Dong , Xin Xu ...
来源:[J].Journal of Neuroinflammation(IF 4.351), 2017, Vol.14 (1)Springer
摘要:Neuroinflammation plays a major role in postoperative cognitive dysfunction (POCD). Accumulated evidence indicates that cannabinoid receptor type 2 (CB2R) can mediate anti-inflammatory and immunomodulatory effects in part by controlling microglial activity. However, the impact of...
作者:Alejandra N. Martinez , Amanda R. Burmeister , Geeta Ramesh ...
来源:[J].Journal of Neuroinflammation(IF 4.351), 2017, Vol.14 (1)Springer
摘要:Substance P (SP) is produced at high levels in the central nervous system (CNS), and its target receptor, neurokinin 1 receptor (NK-1R), is expressed by glia and leukocytes. This tachykinin functions to exacerbate inflammatory responses at peripheral sites. Moreover, SP/NK-1R int...
作者:Doris Lam , Starlee Lively , Lyanne C. Schlichter
来源:[J].Journal of Neuroinflammation(IF 4.351), 2017, Vol.14 (1)Springer
摘要:Acute CNS damage is commonly studied using rat and mouse models, but increasingly, molecular analysis is finding species differences that might affect the ability to translate findings to humans. Microglia can undergo complex molecular and functional changes, often studied by in ...
作者:Haiying Zhang , Joon Ha Park , Sony Maharjan ...
来源:[J].Journal of Neuroinflammation(IF 4.351), 2017, Vol.14 (1)Springer
摘要:Blood–brain barrier (BBB) breakdown and inflammation are critical events in ischemic stroke, contributing to aggravated brain damage. The BBB mainly consists of microvascular endothelial cells sealed by tight junctions to protect the brain from blood-borne substances. Thus, ...
作者:Jie Qu , Xue-You Tao , Peng Teng ...
来源:[J].Journal of Neuroinflammation(IF 4.351), 2017, Vol.14 (1)Springer
摘要:Long-term use of morphine induces analgesic tolerance, which limits its clinical efficacy. Evidence indicated morphine-evoked neuroinflammation mediated by toll-like receptor 4 (TLR4) - NOD-like receptor protein 3 (NLRP3) inflammasome was important for morphine tolerance. In our ...
作者:Yoshinori Haraguchi , Yoshito Mizoguchi , Masahiro Ohgidani ...
来源:[J].Journal of Neuroinflammation(IF 4.351), 2017, Vol.14 (1)Springer
摘要:Microglia are resident innate immune cells which release many factors including proinflammatory cytokines or nitric oxide (NO) when they are activated in response to immunological stimuli. Pathophysiology of Alzheimer’s disease (AD) is related to the inflammatory responses m...
作者:Antwoine Flowers , Harris Bell-Temin , Ahmad Jalloh ...
来源:[J].Journal of Neuroinflammation(IF 4.351), 2017, Vol.14 (1)Springer
摘要:Age is the primary risk factor for many diseases. As such, age is a critical co-factor for examination in order to understand the progression and potential intervention in disease progression. Studies examining both the phenotype and transcriptome of aged microglia demonstrated a...
作者:Yingbo He , Natalie Taylor , Lawrence Fourgeaud ...
来源:[J].Journal of Neuroinflammation(IF 4.351), 2017, Vol.14 (1)Springer
摘要:ATP-gated P2X7 is a non-selective cation channel, which participates in a wide range of cellular functions as well as pathophysiological processes including neuropathic pain, immune response, and neuroinflammation. Despite its abundant expression in microglia, the role of P2X7 in...

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