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作者:Montoro-García Silvia , Alburquerque-González Begoña , Bernabé-García Ángel ...
来源:[J].Journal of molecular medicine (Berlin, Germany), 2020
摘要:Tumor invasion and metastasis involve processes in which actin cytoskeleton rearrangement induced by Fascin1 plays a crucial role. Indeed, Fascin1 has been found overexpressed in tumors with worse prognosis. Migrastatin and its analogues target Fascin1 and inhibit its activi...
作者:Polányi Laura , Niessen Carien M , Vohlen Christina ...
来源:[J].Journal of molecular medicine (Berlin, Germany), 2020, Vol.98 (2), pp.279-289
摘要:Intrauterine growth restriction (IUGR) and low birth weight are risk factors for childhood asthma. Atopic march describes the progression from early dermatitis to asthma during life. Since inflammatory signaling is linked to increased airway resistance and lung remodeling in...
作者:Amado Tiago , Amorim Ana , Enguita Francisco J ...
来源:[J].Journal of molecular medicine (Berlin, Germany), 2020, Vol.98 (2), pp.309-320
摘要:CD8+ T cells are key players in immunity against intracellular infections and tumors. The main cytokine associated with these protective responses is interferon-γ (IFN-γ), whose production is known to be regulated at the transcriptional level during CD8+...
作者:Ma Xiaomin , Qiu Yumin , Zhu Lihui ...
来源:[J].Journal of molecular medicine (Berlin, Germany), 2020, Vol.98 (2), pp.221-232
摘要:NOD1 is an innate immune sensor playing an important role in fighting against infection. However, its role in cancer is far from being clarified, and whether NOD1 plays a role in the progression of hepatocellular carcinoma (HCC) has never been reported. Here, we found that NOD1 e...
作者:Duan Ying , Qiu Yumei , Huang Xiaowen ...
来源:[J].Journal of molecular medicine (Berlin, Germany), 2020, Vol.98 (2), pp.291-307
摘要:Four-and-a-half LIM domains protein 2 (FHL2) has been proposed involving in β-catenin activity. We previously reported that FHL2 mediates TGF-β1-induced tubular epithelial-to-mesenchymal transition through activating Wnt/β-catenin signaling. However, the potential role and m...
作者:Beck Sascha , Sehl Carolin , Voortmann Sylvia ...
来源:[J].Journal of molecular medicine (Berlin, Germany), 2020, Vol.98 (2), pp.209-219
摘要:Periprosthetic infection (PPI) is a devastating complication in joint replacement surgery. On the background of an aging population, the number of joint replacements and associated complications is expected to increase. The capability for biofilm formation and the increasing...
作者:Vorwald Charlotte E , Joshee Shreeya , Leach J Kent
来源:[J].Journal of molecular medicine (Berlin, Germany), 2020
摘要:Cell-based therapeutic approaches are an exciting strategy to replenish compromised endothelial cell (EC) populations that contribute to impaired vasculogenesis. Co-cultures of ECs and mesenchymal stromal cells (MSCs) can enhance neovascularization over ECs alone, but the ef...
作者:Abi Nahed Roland , Reynaud Deborah , Lemaitre Nicolas ...
来源:[J].Journal of molecular medicine (Berlin, Germany), 2020, Vol.98 (1), pp.123-133
摘要:Preeclampsia (PE) is the most threatening pathology of human pregnancy. Its development is thought to be due to a failure in the invasion of trophoblast cells that establish the feto-maternal circulation. Protein kinase CK2 is a ubiquitous enzyme reported to be involved in t...
作者:Wang Shawn Yongshun , Zhu Siyu , Wu Jian ...
来源:[J].Journal of molecular medicine (Berlin, Germany), 2020, Vol.98 (2), pp.245-261
摘要:Diabetic cardiomyopathy (DCM) is a major cause of morbidity and mortality in diabetic patients. Reactive oxygen species (ROS) produced by oxidative stress play an important role in the development of DCM. DCM involves abnormal energy metabolism, thereby reducing energy produ...

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