全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Rich E.A.
来源:[J].Journal of Biomedical Science(IF 2.458), 1998, Vol.5 (1), pp.1-10Karger
摘要:The lung is prominently afflicted during the course of HIV-1 disease by both infectious and noninfectious complications. Direct or indirect effects of HIV-1 are likely central to the pathogenesis of these complications. Thus, any changes in viral load locally would negatively imp...
作者:Maury W.
来源:[J].Journal of Biomedical Science(IF 2.458), 1998, Vol.5 (1), pp.11-23Karger
摘要:Equine infectious anemia virus (EIAV) is an ungulate lentivirus that is related to human immunodeficiency virus (HIV). Much of the understanding of lentiviral gene regulation comes from studies using HIV. HIV studies have provided insights into molecular regulation of EIAV expres...
作者:Jeang K.-T.
来源:[J].Journal of Biomedical Science(IF 2.458), 1998, Vol.5 (1), pp.24-27Karger
摘要:The HIV-1 Tat protein is an RNA-binding transcriptional transactivator. Recent findings suggest that Tat associates with a cellular kinase that phosphorylates the carboxyl-terminal domain of the largest subunit of RNA polymerase II. Here we review, in brief, the role of Tat-assoc...
作者:Tsuang M.T.
来源:[J].Journal of Biomedical Science(IF 2.458), 1998, Vol.5 (1), pp.28-30Karger
摘要:Evidence for genetic factors in schizophrenia is reviewed with regard to family, twin and adoption studies, and recent advances in molecular genetic technology are applied to explore possible gene loci susceptible to schizophrenia. Application of neuropsychological and neuroimagi...
作者:Krebs F.C. , Mehrens D. , Pomeroy S. ...
来源:[J].Journal of Biomedical Science(IF 2.458), 1998, Vol.5 (1), pp.31-44Karger
摘要:The generation of genomic diversity during the course of infection has the potential to affect all aspects of HIV-1 replication, including expression of the proviral genome. To gain a better understanding of the impact of long terminal repeat (LTR) sequence diversity on LTR-direc...
作者:Tokuyama S. , Zhu H. , Wakabayashi H. ...
来源:[J].Journal of Biomedical Science(IF 2.458), 1998, Vol.5 (1), pp.45-53Karger
摘要:To investigate the role of glutamate in the locus coeruleus (LC) during opioid withdrawal, rats were continuously infused with morphine (a µ-opioid receptor agonist, 26 nmol/µl/h) or butorphanol (a µ/δ/κ-mixed opioid receptor agonist, 26 nmol/µl/h) intracerebrove...
作者:Totsuka T. , Watanabe K. , Uramoto I. ...
来源:[J].Journal of Biomedical Science(IF 2.458), 1998, Vol.5 (1), pp.54-61Karger
摘要:Muscular dystrophy has long been believed to be characterized by degeneration and abortive regeneration of muscle fibers (the muscle degeneration theory), but unfortunately its pathogenesis is still unclear and an effective treatment has yet to be developed. As a challenge to the...
作者:Jong A.Y. , Yu K. , Zhou B. ...
来源:[J].Journal of Biomedical Science(IF 2.458), 1998, Vol.5 (1), pp.62-68Karger
摘要:Ribonucleotide reductase (RR) is a key regulatory enzyme in the DNA synthesis pathway and is the target of the cancer chemotherapeutic agent hydroxyurea. The study of RR is significantly hindered by the tedious and labor-intensive nature of enzymatic assay. In this report, we pre...
作者:Kung H.-J. , Chen H.-C. , Robinson D.
来源:[J].Journal of Biomedical Science(IF 2.458), 1998, Vol.5 (2), pp.74-78Karger
摘要:As the post-genome era is approaching, with vast amount of sequence information available and new technology developed, scientists are presented with opportunities to explore in simple analysis the structure and expression pattern of not just a single gene, but of an entire ...
作者:Garcia R. , Jove R.
来源:[J].Journal of Biomedical Science(IF 2.458), 1998, Vol.5 (2), pp.79-85Karger
摘要:Signal transducers and activators of transcription (STATs) are cytoplasmic transcription factors that translocate to the nucleus and regulate gene expression in response to cytokine and growth factor stimulation. Emerging evidence indicates that STAT signaling is also frequently ...

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