全部文献期刊会议图书|学者科研项目
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作者:Emanuela Galliera , Monica Gioia Marazzi , Carmine Gazzaruso ...
来源:[J].Immunity & Ageing, 2017, Vol.14 (1)Springer
摘要:Osteoporosis is a systemic metabolic disease based on age-dependent imbalance between the rates of bone formation and bone resorption. Recent studies on the pathogenesis of this disease identified that bone remodelling impairment, at the base of osteoporotic bone fragility, could...
作者:Sarah Tremblay , Nathalie Marie Louise Côté , Guillaume Grenier ...
来源:[J].Immunity & Ageing, 2017, Vol.14 (1)Springer
摘要:In an effort to understand the mechanisms underlying the high prevalence of gastrointestinal tract disorders in old age, we investigated the expression of intestinal antimicrobial peptides in the terminal small intestine of aged mice. Our results show that old mice have redu...
作者:Birgit Weinberger , Michael Keller , Beatrix Grubeck-Loebenstein
来源:[J].Immunity & Ageing, 2017, Vol.14 (1)Springer
摘要:Many currently used vaccines are less immunogenic in the elderly compared to young adults. The impact of latent infection with Cytomegalovirus (CMV) on vaccine-induced antibody responses has been discussed controversially. We have demonstrated that recall responses to diphth...
作者:Kornelis S. M. van der Geest , Qi Wang , Thijs M. H. Eijsvogels ...
来源:[J].Immunity & Ageing, 2017, Vol.14 (1)Springer
摘要:Age-related changes of the immune system, termed immunosenescence, may underlie the increased risk of infections and morbidity in the elderly. Little is known about the effects of acute exercise on peripheral immune parameters in octogenarians. Therefore, we investigated acu...
作者:Ling Huang , Nicolle H. R. Litjens , Nynke M. Kannegieter ...
来源:[J].Immunity & Ageing, 2017, Vol.14 (1)Springer
摘要:Patients with end-stage renal disease (ESRD) have an impaired immune response with a prematurely aged T-cell system. Mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (ERK) and p38, regulate diverse cellular programs by transferring extrace...
作者:Jürgen M. Bauer , Antonio De Castro , Nabil Bosco ...
来源:[J].Immunity & Ageing, 2017, Vol.14 (1)Springer
摘要:The age-related dysregulation of the immune system in older persons results in reduced responses to vaccination and greater susceptibility to infection, especially in frail individuals who suffer the greatest of morbidity and mortality due to infection. Recently, significant...
作者:Bjørn Grinde , Bo Engdahl
来源:[J].Immunity & Ageing, 2017, Vol.14 (1)Springer
摘要:It has recently been shown that the leukotriene receptor antagonist montelukast rejuvenates aged brains in rats. The question is whether this commonly used, systemic, anti-asthmatic medicine has a similar effect in humans?
作者:William Galbavy , Yong Lu , Martin Kaczocha ...
来源:[J].Immunity & Ageing, 2017, Vol.14 (1)Springer
摘要:We have previously reported elevated expression of multiple pro-inflammatory markers in the lumbar spinal cord (LSC) of middle-aged male rats compared to young adults suggesting a para-inflammatory state develops in the LSC by middle age, a time that in humans is associated with ...
作者:Lucyna Kaszubowska , Jerzy Foerster , Jan Jacek Kaczor ...
来源:[J].Immunity & Ageing, 2017, Vol.14 (1)Springer
摘要:NK cells are key effector lymphocytes of innate immunity provided with constitutive cytolytic activity, however, their role in human ageing is not entirely understood. The study aimed to analyze the expression of proteins involved in cellular stress response sirtuin 1 (SIRT1), he...

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