全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Gao G. , Kang G. , Wang J. ...
来源:[J].Human Heredity(IF 1.569), 2012, Vol.73 (1), pp.1-13Karger
摘要:Background/Objectives: For genome-wide association studies (GWAS) with case-control designs, one of the most widely used association tests is the Cochran-Armitage (CA) trend test assuming an additive mode of inheritance. The CA trend test often has higher power than other associa...
作者:Wellek S. , Ziegler A.
来源:[J].Human Heredity(IF 1.569), 2012, Vol.73 (1), pp.14-17Karger
摘要:Objective: The Cochran-Armitage trend test based on the linear regression model has become a standard procedure for association testing in case-control studies. In contrast, the logistic regression model is generally used for estimating effect sizes. The aim of this paper is to p...
作者:Sung Y.J. , Wang L. , Rankinen T. ...
来源:[J].Human Heredity(IF 1.569), 2012, Vol.73 (1), pp.18-25Karger
摘要:Genotype imputations based on 1000 Genomes (1KG) Project data have the advantage of imputing many more SNPs than imputations based on HapMap data. It also provides an opportunity to discover associations with relatively rare variants. Recent investigations are increasingly using ...
作者:Chen Z. , Ng H.K.T.
来源:[J].Human Heredity(IF 1.569), 2012, Vol.73 (1), pp.26-34Karger
摘要:In genetic association studies, due to the varying underlying genetic models, no single statistical test can be the most powerful test under all situations. Current studies show that if the underlying genetic models are known, trend-based tests, which outperform the classical Pea...
作者:Won S. , Lu Q. , Bertram L. ...
来源:[J].Human Heredity(IF 1.569), 2012, Vol.73 (1), pp.35-46Karger
摘要:For the meta-analysis of genome-wide association studies, we propose a new method to adjust for the population stratification and a linear mixed approach that combines family-based and unrelated samples. The proposed approach achieves similar power levels as a standard meta-analy...
作者:Lopes M.C. , Joyce C. , Ritchie G.R.S. ...
来源:[J].Human Heredity(IF 1.569), 2012, Vol.73 (1), pp.47-51Karger
摘要:Aims: Next-generation sequencing has opened the possibility of large-scale sequence-based disease association studies. A major challenge in interpreting whole-exome data is predicting which of the discovered variants are deleterious or neutral. To address this question in silico,...
作者:Ma L. , Wong W.H. , Owen A.B.
来源:[J].Human Heredity(IF 1.569), 2012, Vol.73 (1), pp.52-61Karger
摘要:Background: Linkage and association analysis based on haplotype transmission disequilibrium can be more informative than single marker analysis. Several works have been proposed in recent years to extend the transmission disequilibrium test (TDT) to haplotypes. Among them, a powe...
作者:Herold C. , Mattheisen M. , Lacour A. ...
来源:[J].Human Heredity(IF 1.569), 2012, Vol.73 (2), pp.63-72Karger
摘要:Objectives: Pathway association analysis (PAA) tests for an excess of moderately significant SNPs in genes from a common pathway. Methods: We present a Monte-Carlo simulation framework that allows to formulate the main ideas of existing PAA approaches using a self-contained ...
作者:Shriner D.
来源:[J].Human Heredity(IF 1.569), 2012, Vol.73 (2), pp.73-83Karger
摘要:Principal components analysis of genetic data has benefited from advances in random matrix theory. The Tracy-Widom distribution has been identified as the limiting distribution of the lead eigenvalue, enabling formal hypothesis testing of population structure. Additionally, a pha...
作者:Asimit J.L. , Day-Williams A.G. , Morris A.P. ...
来源:[J].Human Heredity(IF 1.569), 2012, Vol.73 (2), pp.84-94Karger
摘要:Objectives: There is increasing evidence that rare variants play a role in some complex traits, but their analysis is not straightforward. Locus-based tests become necessary due to low power in rare variant single-point association analyses. In addition, variant quality scores ar...

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