全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Cristian Smerdou , Peter Liljeström
来源:[J].Gene Therapy and Regulation, 2000, Vol.1 (1), pp.33 -63Brill Press
摘要:Alphaviruses are enveloped viruses containing a single positive strand RNA molecule as genome. Several vectors derived from alphaviruses have been developed, which include Sindbis virus (SIN), Semliki Forest virus (SFV), and Venezuelan Equine Encephalitis virus (VEE). Alphavirus ...
作者:Ralf Kircheis , Ernst Wagner
来源:[J].Gene Therapy and Regulation, 2000, Vol.1 (1), pp.95 -114Brill Press
摘要:A major aim of in vivo gene transfer strategies is the efficient and specific delivery of therapeutic genes into the desired target tissues. Non-viral vectors, based on naked plasmid DNA or DNA complexes with cationic lipids or polycationic polymers, are attractive gene delivery ...
作者:Catherine H. Wu , Cherie M. Walton , George Y. Wu
来源:[J].Gene Therapy and Regulation, 2000, Vol.1 (2), pp.193 -205Brill Press
摘要:In hepatic fibrosis, the connective tissue biomatrix of the liver changes from the normal matrix, rich in basement membrane collagens, to a matrix enriched in interstitial fibrillar collagens. Type I collagen is the predominant component of thick fibrous bands found in matri...
作者:Yihai Cao
来源:[J].Gene Therapy and Regulation, 2000, Vol.1 (2), pp.123 -139Brill Press
摘要:A number of potent endogenous inhibitors targeting the tumor vasculature have recently been identified in tumor-bearing animals. Some of these angiogenesis inhibitors, including angiostatin, endostatin, and serpin antithrombin, seem to act specifically on the proliferating endoth...
作者:Candace Summerford , Jeffrey S. Bartlett , Richard Jude Samulski
来源:[J].Gene Therapy and Regulation, 2000, Vol.1 (1), pp.9 -32Brill Press
摘要:A wide stream of in vivo studies have now confirmed the prediction that rAAV vectors have the primary requirements for effective gene transfer. AAV vectors can efficiently transduce both dividing and non-dividing cells, they are able to mediate long-term gene expression, and are ...
作者:Toshiko Fukuma , George Y. Wu , Catherine H. Wu
来源:[J].Gene Therapy and Regulation, 2000, Vol.1 (1), pp.79 -93Brill Press
摘要:Gene transfer to the liver by receptor-mediated endocytosis represents a promising method for therapeutic intervention of genetic disorders and acquired diseases affecting the liver. Based on the observation that asialoglycoprotein receptors are abundantly expressed on the surfac...
作者:Jörn Stitz , Christian J. Buchholz , Klaus Cichutek
来源:[J].Gene Therapy and Regulation, 2000, Vol.1 (2), pp.177 -192Brill Press
摘要:One of the strategies used to alter the tropism of retroviral vectors involves the substitution of their envelope glycoproteins with those of other viruses. This results in the generation of pseudotype vector particles exhibiting properties that may be advantageous for gene trans...
作者:Ken Suzuki , Hiroshi Nakashima , Yoshiki Sawa ...
来源:[J].Gene Therapy and Regulation, 2000, Vol.1 (1), pp.65 -77Brill Press
摘要:Using UV-inactivated whole HVJ (Hemagglutinating Virus of Japan; Sendai virus), we have developed HVJ-liposomes that are efficient in vitro and in vivo gene delivery vehicles based on cell fusion properties of the Sendai virus. However, all the proteins and the genome of HVJ rema...

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