全部文献期刊会议图书|学者科研项目
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作者:Alessandra Pecorelli , Carlo Cervellati , Valeria Cordone ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2020, Vol.152, pp.100-106
摘要:Abstract(#br)Mutations in X-linked gene methyl-CpG-binding protein 2 ( MECP2 ), a key transcriptional regulator, account for most cases of Rett syndrome (RTT), a devastating neurodevelopmental disorder with no known cure. Despite extensive research to elucidate MeCP2 functions, t...
作者:Jialong Yan , Jinyong Jiang , Lu He ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2020, Vol.152, pp.33-42
摘要:Abstract(#br)Mitochondria are well known for their roles as energy and metabolic factory. Mitochondrial reactive oxygen species (mtROS) refer to superoxide anion radical ( • O 2 − ) and hydrogen peroxide (H 2 O 2 ). They are byproducts of electron transport in mitochondrial ...
作者:Martin Škandík , Nataša Mrvová , Štefan Bezek ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2020, Vol.152, pp.18-32
摘要:Abstract(#br)During brain ageing, microglia, the resident immune cells of the CNS, are immunologically activated and contribute to neuroinflammation, a vicious cycle that supports development of neurological disorders. Therapeutic approaches focus mainly on downregulation of...
作者:Ze Chen , Ruifeng Tian , Zhigang She ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2020, Vol.152, pp.116-141
摘要:Abstract(#br)Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver disease worldwide and is strongly associated with the presence of oxidative stress. Disturbances in lipid metabolism lead to hepatic lipid accumulation, which affects different...
作者:Sue Goo Rhee , Hyun Ae Woo
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2020, Vol.152, pp.107-115
摘要:Abstract(#br)Peroxiredoxins (Prxs) are an unusual family of thiol-specific peroxidases that possess a binding site for H 2 O 2 and rely on a conserved cysteine residue for rapid reaction with H 2 O 2 . Among 6 mammalian isoforms (Prx I to VI), Prx I and Prx II are mainly found in...
作者:Andreas Daiber , Stefan Chlopicki
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2020
摘要:Abstract(#br)According to the latest Global Burden of Disease Study data, non-communicable diseases in general and cardiovascular disease (CVD) in particular are the leading cause of premature death and reduced quality of life. Demographic shifts, unhealthy lifestyles and a ...
作者:Tony Y. Momma , Javier I. Ottaviani
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2020, Vol.152, pp.74-82
摘要:Abstract(#br)There has been a renewed interest in the enzyme arginase for its role in various physiological and pathological processes that go beyond the urea cycle. One such role ascribed to arginase has been that of regulating nitric oxide (NO) production by a substrate ( ...
作者:Yunen Liu , Changci Tong , Yushan Tang ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2020, Vol.152, pp.52-60
摘要:Abstract(#br)Although Tanshinone IIA (Tan IIA) has been associated with inflammation, oxidative stress and apoptosis, the effects of Tan IIA on lung blast injury remain uncertain. In this study, we explored the effects of Tan IIA on lung blast injury, studied its possible mo...
作者:Eduardo Fuentes-Lemus , Michele Mariotti , Juan Reyes ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2020, Vol.152, pp.61-73
摘要:Abstract(#br)Photosensitized protein oxidation is a promising tool for medical procedures such as photochemical tissue bonding (PTB). We have recently reported that the binding of rose Bengal, a sensitizer employed in PTB, to lysozyme modulates the photooxidation and crossli...
作者:Nina Dickerhof , Jie Huang , Elysia Min ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2020, Vol.152, pp.91-99
摘要:Abstract(#br)Background(#br)Cystic fibrosis (CF) lung disease is characterized by severe bacterial infections, excessive neutrophilic inflammation and oxidative stress. The neutrophil enzyme myeloperoxidase (MPO), which produces hypochlorous acid, is associated with worse di...

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