全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Sara A. Mansfield , Robert Pilarski , Doreen M. Agnese
来源:[J].Familial Cancer(IF 1.935), 2017, Vol.16 (3), pp.407-410Springer
摘要:The ataxia-telangiectasia mutated (ATM) gene encodes a protein kinase involved in DNA repair. Heterozygotic carriers are at an increased risk of developing breast cancer. As the use of genetic testing increases, identification of at-risk patients will also increase. The aim of th...
作者:Jun-Long Song , Chuang Chen , Jing-Ping Yuan ...
来源:[J].Familial Cancer(IF 1.935), 2017, Vol.16 (3), pp.339-349Springer
摘要:Whether a positive family history of breast cancer or ovarian cancer (FHBOC) would affect the prognosis of breast cancer is still up for debate and further study. This meta-analysis was performed to clarify this issue. We reviewed two databases (PubMed and CNKI) for research...
作者:Jy-Ming Chiang , Tse-Ching Chen
来源:[J].Familial Cancer(IF 1.935), 2017, Vol.16 (4), pp.555-560Springer
摘要:Peutz–Jeghers syndrome (PJS) is a rare hereditary disorder characterized by hamartomatous polyps in both of the gastrointestinal tract and mucosal pigmentation. It could increase in risk of intestinal and extra-intestinal neoplasms. We here described three cases of sinonasal...
作者:Leora Witkowski , Nancy Donini , Rebecca Byler-Dann ...
来源:[J].Familial Cancer(IF 1.935), 2017, Vol.16 (3), pp.395-399Springer
摘要:Small cell carcinoma of the ovary, hypercalcemic type, (SCCOHT) is the most common undifferentiated ovarian cancer in women aged under 40 years. SCCOHT is a monogenic disease, characterized by germline and somatic SMARCA4 mutations. Recent studies have stressed its morphological ...
作者:Kate A. McBride , Mandy L. Ballinger , Timothy E. Schlub ...
来源:[J].Familial Cancer(IF 1.935), 2017, Vol.16 (3), pp.423-432Springer
摘要:Germline TP53 mutation carriers are at high risk of developing a range of cancers. Effective cancer risk management is an important issue for these individuals. We assessed the psychosocial impact in TP53 mutation carriers of WB-MRI screening as part of the Surveillance in M...
作者:Jessica Ezzell Hunter , Kathleen A. Arnold , Jennifer E. Cook ...
来源:[J].Familial Cancer(IF 1.935), 2017, Vol.16 (3), pp.377-387Springer
摘要:Universal screening for Lynch syndrome (LS) among all cases of colorectal cancer (CRC) could increase the diagnosis of LS and reduce morbidity and mortality of LS-associated cancers. Given universal screening includes all patients, irrespective of high risk factors such early age...
作者:Mohamed Ragab Youssef , Zeinab Ibraheim Attia , Rizk Ahmed El-Baz ...
来源:[J].Familial Cancer(IF 1.935), 2017, Vol.16 (4), pp.517-524Springer
摘要:To assess the association of genetic polymorphisms of NFκB1 and NFκBIA genes with the susceptibility to colorectal cancer (CRC). Subjects included 100 Egyptian patients with CRC (60 males and 40 females) in addition to 85 healthy controls (47 males and 38 females) from the s...
作者:Hu Tan , Xianda Wei , Pu Yang ...
来源:[J].Familial Cancer(IF 1.935), 2017, Vol.16 (3), pp.417-422Springer
摘要:Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant disorder characterized by mucocutaneous hyperpigmentation, gastrointestinal (GI) hamartmatous polyps, and an increased risk of various malignancies. Pathogenic variants in the LKB1 tumor suppressor gene (also known as STK1...
作者:Nina Hallowell , Shirlene Badger , Sue Richardson ...
来源:[J].Familial Cancer(IF 1.935), 2017, Vol.16 (4), pp.531-535Springer
摘要:Reproductive genetic testing- PreNatal Diagnosis (PND) and Preimplantation Genetic Diagnosis (PGD)—for CDH1 mutations associated with Hereditary Diffuse Gastric Cancer (HDGC)is available in the UK. This qualitative interview study examined high-risk individuals’ (n = 35) vie...
作者:Sumadee De Silva , Kamani Hemamala Tennekoon , Aravinda Dissanayake ...
来源:[J].Familial Cancer(IF 1.935), 2017, Vol.16 (3), pp.329-338Springer
摘要:Women with breast carcinoma diagnosed before 40 years of age with a strong familial risk have a greater prevalence of germline BRCA1 or BRCA2 variants than late onset breast cancer. Previously germline variants in BRCA1 and BRCA2 genes were characterized in a cohort of Sri Lankan...

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