全部文献期刊会议图书|学者科研项目
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作者:Guanyin Yuan , Yang Jing , Ting Wang ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2020
摘要:Abstract(#br)Bitter taste receptors (Tas2rs), the members of the G-protein-coupled receptors, mediate the bitter taste and express in extra-oral tissues. Previous studies have shown that Tas2r mRNAs are expressed in the whole heart and cultured cardiomyocytes of neonatal rat...
作者:Xiao-Fang Mao , Muhammad Zaeem Ahsan , Evhy Apryani ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2020
摘要:Abstract(#br)Dezocine is an opioid analgesic widely used in China, occupying over 45% of the domestic market of opioid analgesics. We have recently demonstrated that dezocine produced mechanical antiallodynia and thermal antihyperalgesia through spinal μ-opioid receptor acti...
作者:Maryam H. Shubbar , Jeffrey I. Penny
来源:[J].European Journal of Pharmacology(IF 2.592), 2020, Vol.874
摘要:Abstract(#br)Deposition of amyloid-β peptide (Aβ (1–42) ) is a hallmark of Alzheimer's disease. Clearance of Aβ (1–42) , across the blood-brain barrier (BBB), is mediated by ATP-binding Cassette (ABC) efflux transporters. Many therapeutic drugs inhibit ABC transporters,...
作者:Jia Zhang , Yuqi Cui , Xin Li ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2020, Vol.876
摘要:Abstract(#br)Synthetic apolipoprotein A-I (apoA-I) mimetic peptide 5F exhibits anti-atherosclerotic ability with largely unknown mechanism(s). Bone marrow ( BM )-derived endothelial progenitor cells (EPCs) play a critical role in vascular integrity and function. The objective of ...
作者:Jiabin Lu , Yuhuai Hu , Renyun Qian ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2020, Vol.874
摘要:Abstract(#br)Glioma is a kind of lethal malignant tumor, and lacks efficient therapies. Combination therapy has been claimed to be a promising approach to combat cancer, due to its increased anti-cancer effects and reduced side effects. This study aimed to investigate the anti-ca...
作者:Ângelo Luís , Helena Marcelino , Carolina Rosa ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2020, Vol.876
摘要:Abstract(#br)Glioblastoma multiforme (GBM) is the most frequent and aggressive malignant brain tumour, with a poor prognosis despite available surgical and radio-chemotherapy, rising the necessity for searching alternative therapies. Several preclinical studies evaluating the eff...
作者:Jin Ryeol An , Mi Seon Seo , Hee Seok Jung ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2020, Vol.874
摘要:Abstract(#br)We evaluated the inhibitory effects of the atypical antipsychotic drug risperidone on voltage-dependent K + (Kv) channels in rabbit coronary arterial smooth muscle cells. Risperidone suppressed Kv currents in reversible and concentration-dependent manners with a...
作者:Wijitra Chumboatong , Satchakorn Khamchai , Chainarong Tocharus ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2020, Vol.874
摘要:Abstract(#br)Stroke is a major cause of death and permanent disability worldwide. It has been reported that 85% of stroke patients undergo an ischaemic stroke. The standard treatment is currently recanalization. However, only 5% of patients have access to this treatment. Therefor...
作者:Shan Wu , Weifeng Yao , Chaojin Chen ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2020, Vol.876
摘要:Abstract(#br)Hepatic ischemia/reperfusion (I/R) injury is a common complication in the clinical setting. Our previous study has shown that connexin 32 (Cx32) plays a major role in renal I/R injury; however, the role of Cx32 in hepatic I/R injury remains unknown. Liver tissue...
作者:Masoumeh Faramarzian , Seifollah Bahramikia , Marzieh Dehghan Shasaltaneh
来源:[J].European Journal of Pharmacology(IF 2.592), 2020, Vol.874
摘要:Abstract(#br)In certain conditions (such as fever and stress) mutated lysozyme enzyme deposits in different tissues and organs in the form of amyloid fibrils (plaques). These aggregates lead to tissue destruction and the pathogenesis of a disease. In this study, we investigated t...

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