全部文献期刊会议图书|学者科研项目
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作者:Wen Zhang , Xiaomin Xiong , Lin Chen ...
来源:[J].European Journal of Drug Metabolism and Pharmacokinetics(IF 0.944), 2017, Vol.42 (4), pp.669-676Springer
摘要:Ophiopogonin D (OPD) is one of the main active ingredients of SMI (Shenmai injection) which is widely used in clinical practice in China. Our previous study indicated that OPD might be transported from blood into liver mediated by organic anion transporting polypeptides (OATPs/oa...
作者:Monique Groen-Wijnberg , Jan van Dijk , Walter Krauwinkel ...
来源:[J].European Journal of Drug Metabolism and Pharmacokinetics(IF 0.944), 2017, Vol.42 (3), pp.417-429Springer
摘要:Mirabegron is a selective β3-adrenoceptor agonist approved for the treatment of overactive bladder (OAB). Four phase 1 studies were conducted in healthy subjects to evaluate the potential for pharmacokinetic interactions between mirabegron and metformin, warfarin, digoxin, o...
作者:Momir Mikov , Maja Đanić , Nebojša Pavlović ...
来源:[J].European Journal of Drug Metabolism and Pharmacokinetics(IF 0.944), 2017, Vol.42 (6), pp.881-890Springer
摘要:Following the drug administration, patients are exposed not only to the parent drug itself, but also to the metabolites generated by drug-metabolizing enzymes. The role of drug metabolites in cytochrome P450 (CYP) inhibition and subsequent drug–drug interactions (DDIs) have ...
作者:Prashant B. Nigade , Jayasagar Gundu , K. Sreedhara Pai ...
来源:[J].European Journal of Drug Metabolism and Pharmacokinetics(IF 0.944), 2017, Vol.42 (5), pp.835-847Springer
摘要:Majority of reported studies so far developed correlation regression equations using the rat muscle-to-plasma drug concentration ratio (Kp-muscle) to predict tissue-to-plasma drug concentration ratios (Kp-tissues). Use of regression equations derived from rat Kp-muscle may not be...
作者:Ziad Hussein , Hitoshi Mizuo , Seiichi Hayato ...
来源:[J].European Journal of Drug Metabolism and Pharmacokinetics(IF 0.944), 2017, Vol.42 (6), pp.903-914Springer
摘要:Lenvatinib is a multikinase inhibitor that targets vascular endothelial growth factor (VEGF) receptors 1–3, fibroblast growth factor receptors 1–4, platelet-derived growth factor receptor-alpha, and RET and KIT proto-oncogenes. Lenvatinib is approved for the treatment of rad...
作者:Aleksandar Rašković , Slobodan Gigov , Ivan Čapo ...
来源:[J].European Journal of Drug Metabolism and Pharmacokinetics(IF 0.944), 2017, Vol.42 (5), pp.849-856Springer
摘要:Apigenin is known to have various pharmacological properties without causing significant toxicity; however, hepatoprotective effect of apigenin is not often reported. The aim of our study was to investigate if the alterations in lipid peroxidation and antioxidant status are in fa...
作者:Mikhail V. Khvostov , Sergey A. Borisov , Tatjana G. Tolstikova ...
来源:[J].European Journal of Drug Metabolism and Pharmacokinetics(IF 0.944), 2017, Vol.42 (3), pp.431-440Springer
摘要:In the present work, pharmacological and pharmacokinetic properties of the supramolecular complex of non-steroid anti-inflammatory drug ibuprofen (IBU) with natural polysaccharide arabinogalactan (AG) were studied. The main goals of such complexation were the increase of ibu...
作者:Xue Fan , Shan-Shan Yin , Xue-Jing Li ...
来源:[J].European Journal of Drug Metabolism and Pharmacokinetics(IF 0.944), 2017, Vol.42 (5), pp.857-869Springer
摘要:Crassicauline A, a C19 diterpenoid alkaloid in Aconitum herbs, is an analgesic drug clinically used in China. The in vivo metabolism of crassicauline A is poorly understood, while potential bioactivation is anticipated via hydroxylation metabolism. This work, therefore...
作者:Ramzi Shawahna , Kayathiri Ganeshamoorthy , Luo Huilong ...
来源:[J].European Journal of Drug Metabolism and Pharmacokinetics(IF 0.944), 2017, Vol.42 (6), pp.1013-1017Springer
摘要:Lithium chloride (LiCl) has been shown to improve the tightness of brain endothelial cell monolayers in vitro by inhibition of the GSK-3β enzyme, activation of the Wnt/beta-catenin pathway and regulation of tight junction (TJ) protein expression. However, the effect of LiCl ...

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