全部文献期刊会议图书|学者科研项目
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来源:[J].Drugs in R & D, 2010, Vol.10 (4), pp.285-285
作者:Peter R. Kowey , Ramagopal V. Mudumbi , Joseph W. Aquilina ...
来源:[J].Drugs in R & D, 2011, Vol.11 (1), pp.1-11
摘要:Abstract(#br)The cardiovascular safety profile of dapoxetine, a novel selective serotonin reuptake inhibitor (SSRI) developed as an on-demand oral treatment for premature ejaculation (PE) in men, is evaluated. The cardiovascular assessment of dapoxetine was conducted throughout a...
作者:Paul Martin , Stuart Oliver , Jane Robertson ...
来源:[J].Drugs in R & D, 2011, Vol.11 (1), pp.37-51
摘要:Abstract(#br) Objective: The aim of this study was to investigate the effects of a potent CYP3A4 inducer, rifampicin (Study A), and a potent CYP3A4 inhibitor, itraconazole (Study B), on the pharmacokinetics of a single 300mg dose of vandetanib in healthy subjects.(#br) Study...
作者:Michael Lissy , Marité Ode , Karsten Roth
来源:[J].Drugs in R & D, 2011, Vol.11 (1), pp.61-75
摘要:Abstract(#br) Objectives: The aim of this study was to investigate the bioequivalence and potency of registered epoetin alfa products that have not been compared before in a randomized controlled clinical study.(#br) Methods: The study was conducted in two parts: part A comp...
作者:Jürgen Frevert
来源:[J].Drugs in R & D, 2011, Vol.11 (1), pp.98-99
作者:Tommaso Iannitti , Daniele Lodi , Beniamino Palmieri
来源:[J].Drugs in R & D, 2011, Vol.11 (1), pp.13-27
摘要:Abstract(#br)Osteoarthritis (OA), also called degenerative joint disease, is the most frequently occurring chronic musculoskeletal disease, particularly affecting the aging population. The use of viscosupplementation, i.e. intra-articular (IA) hyaluronic acid (HA) drug therapy, t...
作者:Cihangir Bicer , Recep Aksu , Ayse Ulgey ...
来源:[J].Drugs in R & D, 2011, Vol.11 (1), pp.29-36
摘要:Abstract(#br) Objective: The aim of this study was to evaluate the efficacy of different doses of palonosetron for the prevention of PONV in children undergoing strabismus surgery.(#br) Patients and Method: A total of 150 children who were classified with an American Society...
作者:Mladena Lalic , Ana Pilipovic , Svetlana Golocorbin-Kon ...
来源:[J].Drugs in R & D, 2011, Vol.11 (1), pp.53-60
摘要:Abstract(#br) Objective: The aim of this study was to investigate the extent of variations in lamotrigine serum concentrations between two immediate-release tablet formulations. Data were compared with in vitro difference and similarity tests on dissolution profiles of the t...
作者:Mohammad Niazi , Stanko Skrtic , Magnus Ruth ...
来源:[J].Drugs in R & D, 2011, Vol.11 (1), pp.77-83
摘要:Abstract(#br) Objective: The aim of this study was to evaluate the pharmacokinetic profile of lesogaberan in healthy subjects after single oral and intravenous administration of 14 C-labeled lesogaberan and non- 14 C-labeled lesogaberan.(#br) Study Design: This was an open-l...

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