全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Hatylas Azevedo , Nathália Amato Khaled , Paula Santos ...
来源:[J].Disease Models & Mechanisms(IF 4.959), 2018, Vol.11 (1)DOAJ
摘要:Complex febrile seizures during infancy constitute an important risk factor for development of epilepsy. However, little is known about the alterations induced by febrile seizures that make the brain susceptible to epileptic activity. In this context, the use of animal models of ...
作者:Hernán H. Dieguez , Horacio E. Romeo , María F. González Fleitas ...
来源:[J].Disease Models & Mechanisms(IF 4.959), 2018, Vol.11 (2)DOAJ
摘要:Non-exudative age-related macular degeneration, a prevalent cause of blindness, is a progressive and degenerative disease characterized by alterations in Bruch's membrane, retinal pigment epithelium, and photoreceptors exclusively localized in the macula. Although experimental mu...
作者:Vimala Kaza , Elena Farmaki , Amanda Havighorst ...
来源:[J].Disease Models & Mechanisms(IF 4.959), 2018, Vol.11 (1)DOAJ
摘要:Modeling breast cancer in general and hormone-sensitive breast cancer, in particular in mice, has several limitations. These are related to the inbred nature of laboratory mice, and do not allow adequate appreciation of the contribution of the host's genetic heterogeneity in tumo...
作者:Gema Marín-Royo , Isabel Gallardo , Ernesto Martínez-Martínez ...
来源:[J].Disease Models & Mechanisms(IF 4.959), 2018, Vol.11 (2)DOAJ
摘要:Obesity is accompanied by metabolic alterations characterized by insulin resistance and cardiac lipotoxicity. Galectin-3 (Gal-3) induces cardiac inflammation and fibrosis in the context of obesity; however, its role in the metabolic consequences of obesity is not totally est...
作者:Gina M. Duggan , Serge Mostowy
来源:[J].Disease Models & Mechanisms(IF 4.959), 2018, Vol.11 (2)DOAJ
摘要:Shigella is a leading cause of dysentery worldwide, responsible for up to 165 million cases of shigellosis each year. Shigella is also recognised as an exceptional model pathogen to study key issues in cell biology and innate immunity. Several infection models have been useful to...
作者:Maria Angeles Marques-Torrejon , Ester Gangoso , Steven M. Pollard
来源:[J].Disease Models & Mechanisms(IF 4.959), 2018, Vol.11 (2)DOAJ
摘要:Glioblastoma multiforme (GBM) is an aggressive incurable brain cancer. The cells that fuel the growth of tumours resemble neural stem cells found in the developing and adult mammalian forebrain. These are referred to as glioma stem cells (GSCs). Similar to neural stem cells,...
作者:Shelly Sorrells , Sara Nik , Mattie Casey ...
来源:[J].Disease Models & Mechanisms(IF 4.959), 2018, Vol.11 (2)DOAJ
摘要:RNA splicing factors are essential for the viability of all eukaryotic cells; however, in metazoans some cell types are exquisitely sensitive to disruption of splicing factors. Neuronal cells represent one such cell type, and defects in RNA splicing factors can lead to neurodegen...
作者:Ute Jungwirth , Antoinette van Weverwijk , Miriam J. Melake ...
来源:[J].Disease Models & Mechanisms(IF 4.959), 2018, Vol.11 (1)DOAJ
摘要:Studying the complex mechanisms underlying breast cancer metastasis and therapy response necessitates relevant in vivo models, particularly syngeneic models with an intact immune system. Two syngeneic spontaneously metastatic sublines, D2A1-m1 and D2A1-m2, were generated from the...
作者:Kathryn Bambino , Chi Zhang , Christine Austin ...
来源:[J].Disease Models & Mechanisms(IF 4.959), 2018, Vol.11 (2)DOAJ
摘要:The rapid increase in fatty liver disease (FLD) incidence is attributed largely to genetic and lifestyle factors; however, environmental toxicants are a frequently overlooked factor that can modify the effects of more common causes of FLD. Chronic exposure to inorganic arsenic (i...

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