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作者:Alejandro Rodríguez-González , Roberto Costumero , Marcos Martinez-Romero ...
来源:[J].Current Bioinformatics(IF 2.017), 2018, Vol.13 (6), pp.573-582Bentham
摘要:Background: The development of diagnostic decision support systems (DDSS) requireshaving a reliable and consistent knowledge based on diseases and their symptoms, signs, and diagnostictests. Physicians are typically the source of this knowledge but it is not always possible to ob...
作者:Yu-di Liao , Zhen-ran Jiang
来源:[J].Current Bioinformatics(IF 2.017), 2019, Vol.14 (5), pp.446-449Bentham
摘要:Background: With the declining trend of new drugs yield each year, morecomprehensive knowledge of drug MoAs can help identify new applications of available drugs anddiscovery novel mechanism of drug action.
作者:Kannan Narayanan Dhiraviam , Suganthana Balasubramanian , Sridhar Jayavel
来源:[J].Current Bioinformatics(IF 2.017), 2018, Vol.13 (2), pp.157-169Bentham
摘要:Background: Inhibition of DPP-IV enzyme is an effective strategy for the treatment of type-2 diabetes mellitus, which involves the degradation of incretin hormones, glucagon like peptide (GLP-1) and gastric inhibitory polypeptide (GIP), being valuable in glucose tolerance an...
作者:Melisa E. Gantner , Lucas N. Alberca , Andrew G. Mercader ...
来源:[J].Current Bioinformatics(IF 2.017), 2017, Vol.12 (3), pp.239-248Bentham
摘要:Background: Breast Cancer Resistance Protein (BCRP or ABCG2) is a polyspecific effluxtransporterwhich belongs to the ATP-binding Cassette superfamily. Up-regulation of BCRP isassociated to multi-drug resistance in a number of conditions, e.g. cancer and epilepsy. Recentproteomic ...
作者:Anindya Sundar Panja , Akash Nag , Bidyut Bandopadhyay ...
来源:[J].Current Bioinformatics(IF 2.017), 2019, Vol.14 (1), pp.70-77Bentham
摘要:Background: Protein Stability Determination (PSD) is a sequence-based bioinformatics toolwhich was developed by utilizing a large input of datasets of protein sequences in FASTA format. ThePSD can be used to analyze the meta-proteomics data which will help to predict and design t...
作者:Yiannis Hatzis , Trias Thireou , Emmanouil Viennas ...
来源:[J].Current Bioinformatics(IF 2.017), 2018, Vol.13 (5), pp.518-528Bentham
摘要:Background: The sequence Arginine-Glycine-Aspartic acid (RGD tripeptide) has beenidentified in most proteins implicated in cell adhesion and signal transduction. Moreover, the RGDparadigm extends to the plant and microbial kingdoms. Investigating this field can be facilitated byc...
作者:Kai-jian Xia , Jian-qiang Wang , Jian Cai
来源:[J].Current Bioinformatics(IF 2.017), 2019, Vol.14 (7), pp.658-666Bentham
摘要:Background: Lung cancer is one of the common malignant tumors. The successful diagnosis of lung cancer depends on the accuracy of the image obtained from medical imaging modalities. Objective: The fusion of CT and PET is combining the complimentary and redundant information both ...
作者:Mehdi Kchouk , Mourad Elloumi
来源:[J].Current Bioinformatics(IF 2.017), 2018, Vol.13 (3), pp.241-252Bentham
摘要:Background: Error Correction is an important task in the analysis and manipulations of NGSdata. The purpose of error correction is to facilitate data analysis for large projects like de novoassembly project. Here we present a new hybrid algorithm for error correction of long read...
作者:Arpit Singh , Razia Rahman , Yasha Hasija
来源:[J].Current Bioinformatics(IF 2.017), 2017, Vol.12 (5), pp.423-430Bentham
摘要:Background: Epigenetics is gaining rapid recognition as it accounts for heritable changes that do not involve changes in the coding sequence, but influences change in gene expressions. DNAmethylation is the most extensively studied epigenetic mechanism and has been observed to pl...
作者:Shivika Gupta , Rajesh Prasad
来源:[J].Current Bioinformatics(IF 2.017), 2018, Vol.13 (2), pp.216-222Bentham
摘要:Background: Genomes of organisms contains a variety of repeated structures of variouslengths and type, interspersed or tandem. Tandem repeats play important role in molecular biology asthey are related to genetic backgrounds of inherited diseases, and also they can serve as marke...

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